Cytokine expression in pediatric subperiosteal orbital abscesses

Fu, S.Y.; Su, Grant W.; McKinley, Steven H.; Yen, Michael T.

doi:10.3129/i07-151

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…Previous studies have shown that steroids can help reduce the cytokine load and improve outcomes in bacterial OC. [12,13] Goldfarb [7] Beck [8] Table 2.…”

Section: Discussionmentioning

confidence: 99%

Orbital Cellulitis Following Uncomplicated Glaucoma Drainage Device Surgery: Case Report and Review of Literature

Zheng

Uhr

Deaner

et al. 2020

JOVR

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Purpose: Orbital cellulitis (OC) is a rare postoperative complication of glaucoma drainage device (GDD) implantation. To date, there have only been 10 reported cases of OC following GDD implantation. Case Report: Here, we report a case of OC in a 57-year-old man who developed pain, proptosis, and limited extraocular motility two days after uneventful Ahmed FP7 implantation in the right eye. Contrast-enhanced computed tomography of the orbits demonstrated fat stranding and a small fluid collection, consistent with OC. He had minimal improvement with intravenous antibiotics and ultimately underwent GDD explantation. A systematic review of the literature showed that the development of OC following GDD implantation can occur in the early or late postoperative period. Immediate hospitalization with intravenous administration of broad-spectrum antibiotics is recommended. Explantation of the infected GDD is often required for source control. Conclusion: OC is a rare postoperative complication of GDD implantation. Prompt evaluation and treatment are required, often combined with GDD explantation.

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“…Previous studies have shown that steroids can help reduce the cytokine load and improve outcomes in bacterial OC. [12,13] Goldfarb [7] Beck [8] Table 2.…”

Section: Discussionmentioning

confidence: 99%

Orbital Cellulitis Following Uncomplicated Glaucoma Drainage Device Surgery: Case Report and Review of Literature

Zheng

Uhr

Deaner

et al. 2020

JOVR

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“…Furthermore, this IL-6 dominant pattern was sustained until the initiation of IVIG and PSL. e elevation of serum IL-6 level also occurs in patients with bacterial infection [23,24]. us, bacterial infection could not be ruled out.…”

Section: Discussionmentioning

confidence: 99%

Kawasaki Disease with an Initial Manifestation Mimicking Bacterial Inguinal Cellulitis

Tanaka

Shimizu

Tokuda

et al. 2020

Case Reports in Pediatrics

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Background. Kawasaki disease (KD) is typically characterized by fever, oral cavity erythematous changes, bilateral bulbar conjunctival injection, skin rash, erythema and edema of the hands and feet, and cervical lymphadenopathy. Some atypical patients with KD initially develop cervical and pharyngeal cellulitis; however, an initial presentation with inguinal cellulitis is extremely rare. In addition, to our knowledge, no report has documented the cytokine profile in a KD patient with cellulitis. Case presentation. A previously healthy 8-year-old Japanese girl was hospitalized following a 2-day history of fever and a 5-day history of pain and erythema in the left inguinal region. She was diagnosed with bacterial inguinal cellulitis and was administered antibiotics. The next day, a polymorphous rash emerged on her trunk. After 3 days of antibiotics, however, her fever continued and the cellulitis had spread over the entire lower abdomen. Simultaneously, the bilateral bulbar conjunctival injection without exudate became more prominent and her lips became erythematous. In addition, erythematous changes on her palms appeared a few hours later, which led to the diagnosis of KD. Since she had a high risk score that predicted no response to initial intravenous immunoglobulin (IVIG) at the initiation of treatment, she was treated with IVIG, intravenous prednisolone (PSL), and oral aspirin. The KD symptoms improved the next day, but the cellulitis did not completely resolve until 2 months after discharge. The patient’s serum cytokine profile at admission had an IL-6 dominant pattern which was consistent with that of patients with KD despite her initial lack of KD symptoms, and the pattern observed at admission was sustained until IVIG and PSL administration. Conclusion. KD should be included in the differential diagnosis for patients presenting with inguinal cellulitis who are unresponsive to initial empiric antibiotics.

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