Cytokine functions of TIMP-1

Ries, Christian

doi:10.1007/s00018-013-1457-3

Cited by 239 publications

(233 citation statements)

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“…17 TIMP-1 may act as a signaling molecule to influence cell growth, cell differentiation, or miRNA-mediated post-transcriptional regulation. 43 In a study with adenovirus-mediated TIMP-1 overexpression in cardiac fibroblasts, the overexpression of TIMP-1 was associated with increased cell proliferation but not with changes in collagen content. 16 Our results showed that the concentration of TIMP-1 increased with an increasing concentration of aldosterone, and that this increase in TIMP-1 concentration was associated with a decrease in MMP-1 activity.…”

Section: Discussionmentioning

confidence: 97%

Aldosterone Induces Tissue Inhibitor of Metalloproteinases-1 Expression and Further Contributes to Collagen Accumulation

et al. 2016

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Abstract-Aldosterone induces myocardial fibrosis. Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a key factor of myocardial fibrosis. This study tested the hypothesis that aldosterone induces TIMP-1 expression and contributes to the fibrotic process. We prospectively enrolled 54 patients with primary aldosteronism, and measured plasma TIMP-1 and echocardiographic parameters. In the cell study, we investigated the possible molecular mechanism by which aldosterone induces TIMP-1 secretion and the effects on collagen accumulation. In the animal study, we measured serum TIMP-1 levels, cardiac TIMP-1 levels, and cardiac structure in an aldosterone infusion mouse model using implantation of aldosterone pellets. In patients with primary aldosteronism, plasma TIMP-1 was correlated with 24-hour urinary aldosterone, left ventricular mass, and impairment of left ventricular diastolic function. In human cardiac fibroblasts, TIMP-1 protein and mRNA expressions were significantly increased by aldosterone through the glucocorticoid receptor/PI3K/Akt/nuclear factor-κB pathway. TIMP-1 small-interfering RNA significantly reduced aldosterone-induced collagen accumulation, and aldosterone did not alter the levels of collagen1a1 or matrix metalloproteinase-1 mRNA. The aldosterone-induced TIMP-1 expression was inversely related to matrix metalloproteinase-1 activity. Furthermore, in the animal model, the serum and cardiac levels of TIMP-1 were significantly elevated in the mice that received aldosterone infusion. This elevation was blocked by RU-486 but not by eplerenone, suggesting that the effect was through glucocorticoid receptors. In a long-term aldosterone infusion model, serum TIMP-1 was associated with serum aldosterone level, cardiac structure, and fibrosis. In conclusion, aldosterone induced TIMP-1 expression in vivo and in vitro. This increased TIMP-1 expression resulted in enhanced collagen accumulation via the suppression of matrix metalloproteinase-1 activity.

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Section: Discussionmentioning

confidence: 97%

Aldosterone Induces Tissue Inhibitor of Metalloproteinases-1 Expression and Further Contributes to Collagen Accumulation

et al. 2016

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“…특히 MMP-9은 tumor necrosis factor-alpha (TNF-α), interleukin-6와 같은 내 독소 염증성 매개체 자극으로 발현이 증가하는 것이 특징이며 섬유아세포에서 collagen의 분해를 촉진시킨다 (Sanceau 등, 2002). MMPs의 활성을 조절하는 인자로 알려진 MMPs의 조직 억제인자(tissue inhibitors of MMPs, TIMPs)는 21-30 kDa의 분자량을 가지며 TIMP-1, TIMP-2, TIMP-3, TIMP-4 등 4종이 알려져 있으며 다양한 유형의 세포에 의해 발현된다 (Iwata 등, 1996;Ries 2014). TIMPs는 MMP와 비 공유적인 결합을 하여 MMP의 기능을 억제하는 것으로 알려져 있고, TIMP-1은 MMP-9과, TIMP-2는 MMP-2와 각각 결합하여 세포 간 기질의 파괴와 재형성 간의 균형을 조절하는 역할을 한다 (Johnson 등, 1994).…”

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Anti-wrinkle effect of berberine by inhibition of MMP-2 and MMP-9 activity in fibroblasts

장영아

이진태

2018

JABC

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We analyzed the antioxidant and anti-wrinkle activities of berberine, isolated from dried rhizome of Coptis japonica Makino, to determine its cosmetic potential. We performed the 3-[4,5-dimethylthiazol]-2-yl]-2,5-diphenyl-tetrazoliumbromide (MTT) assay to evaluate the toxicity of the berberine. We also measured the ROS and hyaluronic acid production, and expression of MMP-2, MMP-9, TIMP-1, TIMP-2, and tumor necrosis factor-alpha (TNF-α) to evaluate the antioxidant and anti-wrinkle activities of berberine, respectively. The cytotoxicity of ultraviolet light, in presence of berberine, was measured by the MTT assay using CCD-986sk fibroblasts, and no cytotoxicity was observed at concentrations less than 25 μg/mL. We also found that berberine decreased ROS production in a concentration-dependent manner and promoted the synthesis of hyaluronic acid. Further, berberine reduced the protein levels and mRNA expression of MMP-2 and MMP-9, which are associated with wrinkle formation, and increased the expression of TIMP-1 and TIMP-2. In addition, the inhibitory effect of berberine on TNF-α, known as pro-inflammatory cytokine, was inhibited by TNF-α gene in a concentrationdependent manner. These results suggest that berberine holds cosmetic value owing to its antioxidant activity, by inhibiting ROS production and anti-wrinkle activity by reducing MMP-2 and MMP-9 and increasing TIMP-1 and TIMP-2 expression.

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“…TIMPs participate in the degradation of extracellular matrix, angiogenesis, apoptosis, differentiation, as well as in proliferation of normal and tumor cells (40). In this regard, patients with melanoma at Stages I-III in comparison with the control group had significantly higher median concentrations of serum TIMP-1, and this increase had an effect on disease-free survival and overall survival.…”

Section: Endogenous Enzyme Inhibitorsmentioning

confidence: 99%

Biomarkers in Malignant Melanoma: Recent Trends and Critical Perspective

Belter

Haase-Kohn

Pietzsch

2017

Cutaneous Melanoma: Etiology and Therapy

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Abstract:The worldwide incidence of malignant melanoma is steadily increasing, suggesting a probable melanoma "epidemic." From a clinical point of view, malignant melanoma still is an unpredictable disease and, once in the advanced stage, allows only scarce therapeutic options. There is an urgent need to identify, characterize, and validate informative biomarkers, biomarker patterns, or surrogate markers in order to not only improve early diagnosis of melanoma but also for differential diagnosis, staging, prognosis, therapy selection, and therapy monitoring. In this chapter, an update on the ongoing debate on serologic and histologic markers such as lactate dehydrogenase, tyrosinase, S100 family of calcium-binding proteins, cyclooxygenase-2, matrix metalloproteinases, and stem and/or progenitor cell markers are presented, and novel, innovative, and promising trends currently being explored are discussed.

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Cytokine functions of TIMP-1

Cited by 239 publications

References 123 publications

Aldosterone Induces Tissue Inhibitor of Metalloproteinases-1 Expression and Further Contributes to Collagen Accumulation

Aldosterone Induces Tissue Inhibitor of Metalloproteinases-1 Expression and Further Contributes to Collagen Accumulation

Anti-wrinkle effect of berberine by inhibition of MMP-2 and MMP-9 activity in fibroblasts

Biomarkers in Malignant Melanoma: Recent Trends and Critical Perspective

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