Cytokine gene expression in chicken cecal tonsils following treatment with probiotics and Salmonella infection

Haghighi, Hamid R.; Abdul-Careem, Mohamed Faizal; Dara, Rozita; Chambers, James R.; Sharif, Shayan

doi:10.1016/j.vetmic.2007.06.026

Cited by 115 publications

(75 citation statements)

References 32 publications

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“…The observation that digestive and respiratory infections diminished in this MMP group when compared to the untreated group may indicate a good connection between the MMP and the immune system. This situation has been demonstrated in other animal species [32][33][34].…”

Section: Discussionsupporting

confidence: 65%

Multispecies Multistrain Probiotic Effects on Calves Development and Health

Indart¹,

Cerone²,

Esteban³

et al. 2012

OJVM

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Experiment was designed to assess alimentary security or any beneficial effect on calve of a multispecies multistrain probiotic (MMP). An experiment with 36 calves, two day old, was conducted to assess the influence of probiotic on growth and health indicators. The treatment period was extended to 45 d. Group 1 received one daily dose of MMP (1.1 × 10 9 CFU per calf) during 20 d. Group 2 was the untreated control. On a weekly basis, every calf in each group was weighed to determine weight gain. Forty five days after the beginning of the experiment, blood samples were obtained from seven animals from Group 1 and six from Group 2, and peripheral blood neutrophils separated in order to determine metabolic and microbicidal activity. There was a significant increase in H 2 O 2 production and NBT reduction test in MMP treated calves. The MMP not only lacks adverse effects when supplied as food additive, but showed health benefits. The prevention of infection and the highly significant increase of phagocytic activity in peripheral blood leukocytes seen in calves strongly suggest an efficient connection between the MMP and the immune system.

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Section: Discussionsupporting

confidence: 65%

Multispecies Multistrain Probiotic Effects on Calves Development and Health

Indart¹,

Cerone²,

Esteban³

et al. 2012

OJVM

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“…This increasing interest is probably due to the need for solid knowledge about the avian intestinal immune system in the framework of the development of vaccines that have to be administered orally (Nagy et al, 2005). Moreover, since the ban on growth-promoting antibiotics, research on the avian GALT is impelled by the search for suitable pre-and probiotics that stimulate the intestinal immune system (Yurong et al, 2005;Haghighi et al, 2008;Khan et al, 2008;Janardhana et al, 2009). The effects of these feed additives are local as well as systemic since they can also stimulate immune responses in other organs via the common mucosal immune system (Cesta, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…When fully mature, the caecal tonsils are of such a large size that they represent a major component of the avian GALT (Janardhana et al, 2009). As a result of their large size, the caecal tonsils are easy to investigate when immune modulation in birds is studied (Yurong et al, 2005;Haghighi et al, 2008;Janardhana et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Locations of gut-associated lymphoid tissue in the 3-month-old chicken: a review

et al. 2010

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“…LITAF is required throughout Salmonella infection. IL-12, secreted by activated macrophages, acts both independently and synergistically on natural killer cells and T helper (Th) cells to induce the production of further IFN-γ, which activates the macrophages through a positive feedback loop (Beal et al, 2004;Withanage et al, 2005;Haghighi et al, 2008;Tohidi et al, 2012). A correlation between cytokine profiles of chickens and their resistance to the infection by Salmonella Typhimurium was found (Mead, 2000).…”

Section: Introductionmentioning

confidence: 95%

“…These immunomodulatory effects of probiotics may be regulated by cytokines produced in gut-associated lymphoid tissue cells (Sato et al, 2009). Among the probiotics species, Lactobacillus is a group of bacteria that have often been used to enhance host immunity for controlling Salmonella infection (Zhang et al, 2007;Haghighi et al, 2008;Chambers & Gong, 2011). It has been described that several cytokinerelated immune mechanisms might have been involved in mediating the effects of Lactobacillus on reducing enteric infection by Salmonella Typhimurium, such as the mechanisms of protection via modulation of pro-inflammatory [like LITAF and gamma interferon (IFN-γ)] and anti-inflammatory [interleukin (IL)-10] cytokines (Nava et al, 2005;Castillo et al, 2011).…”

Section: Introductionmentioning

confidence: 99%