Cytokine gene expression profiles in kidney medulla and cortex of obese hypertensive dogs

Gu, Jian‐Wei; Wang, Julie; Stockton, A. B.; Lokitz, Bradley S.; Henegar, Lisa; Hall, John E.

doi:10.1111/j.1523-1755.2004.00793.x

Cited by 18 publications

(11 citation statements)

References 47 publications

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“…Postprandial hyperchylomicronemia and hypercomplementemia near adipose tissue would activate the complement pathway and accelerate C3 tick-over, resulting in overproduction of ASP in obese patients with increased amounts of adipose tissue, and hyperinsulinemia in patients with insulin-resistant type 2 diabetes mellitus. Hyperproduction of ASP induced by chylomicron would promote excess complement activation in organs other than adipose tissue, as well as the mRNA expression of genes associated with metabolic syndrome (48). Hyperproduction of ASP may increase the risk of metabolic syndrome and diabetic complications.…”

Section: Discussionmentioning

confidence: 99%

Chylomicron accelerates C3 tick‐over by regulating the role of Factor H, leading to overproduction of acylation stimulating protein

Fujita

Fujioka

Murakami

et al. 2007

Clinical Laboratory Analysis

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Acylation stimulating protein (ASP) is a fragment of the third component of complement (C3) that is generated in the presence of chylomicron, and plays a role in the synthesis of triacylglycerol by transporting free fatty acids into adipocytes. However, the precise mechanism of ASP generation, especially the role of chylomicron in ASP generation, is unknown. We examined the mechanism through which chylomicron induces ASP generation. Ultracentrifugationally separated chylomicron was incubated with normal human serum (NHS) under various conditions, and the amounts of complement activation products and ASP in the incubation mixture were determined by enzyme-linked immunosorbent assay (ELISA). Upon incubation of NHS with various amounts of chylomicron for 120 min, ASP was generated in a dose-dependent manner. The time course of the production of ASP was similar to the time course of the C3 tick-over phenomenon that occurred by depletion of factor H from the serum. The complement activation induced by chylomicron was different from the usual complement activation that occurs under the regulation of factor H and factor I with respect to the time course and the amount of ASP produced. Our results indicate that chylomicron accelerates C3 tick-over by regulating the role of factor H, leading to the overproduction of ASP.

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Section: Discussionmentioning

confidence: 99%

Chylomicron accelerates C3 tick‐over by regulating the role of Factor H, leading to overproduction of acylation stimulating protein

Fujita

Fujioka

Murakami

et al. 2007

Clinical Laboratory Analysis

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“…An experimental study in dogs showed that a high-fat diet causes obesity, increased arterial pressure, hyperinsulinemia, activation of the renin-angiotensin system, glomerular hyperfiltration, and structural changes in the kidney (27). A high-fat diet in dogs is also associated with marked changes in renal cytokine gene expression profiles (28).…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome and Risk of Developing Chronic Kidney Disease in Japanese Adults

Tozawa¹,

et al. 2007

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“…High-fat feeding dogs (supplementing standard food with an additional 0.5-0.9 kg of cooked beef fat/day) for 10 wk led to significantly increased kidney and total body weight, mean arterial blood pressure, and heart rate, accompanied by induction of TGF-␤1 and other proinflammatory cytokines and profibrotic factors in the medullary interstitium, along with enhanced glomerular filtration rate and higher renal plasma flow (63). Moreover, plasma renin was significantly elevated in high fat-fed dogs, supporting the evidence for an activation of the RAAS by the Western-style diet.…”

Section: A High-fat Diet As a Risk Factor For Ckdmentioning

confidence: 99%

The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease

Odermatt

2011

American Journal of Physiology-Renal Physiology

217

128

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The Western-style diet is characterized by its highly processed and refined foods and high contents of sugars, salt, and fat and protein from red meat. It has been recognized as the major contributor to metabolic disturbances and the development of obesity-related diseases including type 2 diabetes, hypertension, and cardiovascular disease. Also, the Western-style diet has been associated with an increased incidence of chronic kidney disease (CKD). A combination of dietary factors contributes to the impairment of renal vascularization, steatosis and inflammation, hypertension, and impaired renal hormonal regulation. This review addresses recent progress in the understanding of the association of the Western-style diet with the induction of dyslipidemia, oxidative stress, inflammation, and disturbances of corticosteroid regulation in the development of CKD. Future research needs to distinguish between acute and chronic effects of diets with high contents of sugars, salt, and fat and protein from red meat, and to uncover the contribution of each component. Improved therapeutic interventions should consider potentially altered drug metabolism and pharmacokinetics and be combined with lifestyle changes. A clinical assessment of the long-term risks of whole-body disturbances is strongly recommended to reduce metabolic complications and cardiovascular risk in kidney donors and patients with CKD.

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Cytokine gene expression profiles in kidney medulla and cortex of obese hypertensive dogs

Abstract: A high fat diet in dogs is associated with marked changes in renal gene expression profiles that provide potential molecular links to pathways associated with altered renal function and structure in obesity hypertension.

Cited by 18 publications

References 47 publications

Chylomicron accelerates C3 tick‐over by regulating the role of Factor H, leading to overproduction of acylation stimulating protein

Chylomicron accelerates C3 tick‐over by regulating the role of Factor H, leading to overproduction of acylation stimulating protein

Metabolic Syndrome and Risk of Developing Chronic Kidney Disease in Japanese Adults

The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease

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