The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease

Odermatt, Alex

doi:10.1152/ajprenal.00068.2011

Cited by 218 publications

(151 citation statements)

References 157 publications

(157 reference statements)

Supporting

Mentioning

136

Contrasting

Unclassified

Order By: Relevance

“…In this work, we found that HFD augmented TGFβ1 and collagen IV gene expression, increased renal lipid accumulation, as well as heightened oxidative stress in both glomerular and tubular compartments in the kidneys of Dia-HF mice, resulting in significant glomerulosclerosis, tubular fibrosis, and apoptosis. Although our findings are consonant with other reports (14)(15)(16), results reported in remnant kidney rats receiving HFD (33) seem to ameliorate these parameters/pathways to prevent kidney injury. Currently, we do not have further explanation for this discrepancy beside species differences.…”

Section: Discussionsupporting

confidence: 91%

“…Compelling evidence from both experimental (14)(15)(16) and human studies (17,18) have suggested that perirenal and/or visceral fat depots may mediate the development of chronic kidney disease and hypertension. CD36 (19)(20)(21)(22) and fatty acid-binding protein 4 (Fabp4) (23)(24)(25)(26)(27) may mediate chronic inflammation, insulin resistance, oxidant stress, and fibrosis involved in proatherogenic hyperlipidemic states such as obesity.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes

et al. 2015

View full text Add to dashboard Cite

Background:The aim of this study was to establish the underlying mechanisms by which a post-weaning high-fat diet (HFD) accelerates the perinatal programming of kidney injury occurring in the offspring of diabetic mothers. Methods: Male mice, offspring of nondiabetic and diabetic dams were fed with normal diet (ND) or HFD from 4 to 20 wk of age. Rat renal proximal tubular cells were used in vitro. results: On ND, the offspring of dams with severe maternal diabetes had an intrauterine growth restriction (IUGR) phenotype and developed mild hypertension and evidence of kidney injury in adulthood. Exposing the IUGR offspring to HFD resulted in rapid weight gain, catch-up growth, and later to profound kidney injury with activation of renal TGFβ1 and collagen type IV expression, increased oxidative stress, and enhanced renal lipid deposition, but not systemic hypertension. Given our data, we speculate that HFD or free fatty acids may accelerate the process of perinatal programming of kidney injury, via increased CD36 and fatty acid-binding protein 4 expression, which may target reactive oxygen species, nuclear factor-kappa B, and TGFβ1 signaling in vivo and in vitro. conclusion: Early postnatal exposure to overnutrition with a HFD increases the risk of development of kidney injury, but not hypertension, in IUGR offspring of dams with maternal diabetes.d iabetes during pregnancy, whether gestational or pregestational diabetes (type 1 or type 2), results in offspring at high risk of developing hypertension, cardiovascular disease, and chronic kidney disease in adult life. This phenomenon, termed perinatal programming, in which intrauterine events are associated with later adverse changes, has attracted much attention (1-3). Substantial epidemiologic data have also suggested that the offspring whose mothers were diabetic during pregnancy are susceptible to metabolic disturbances induced by postnatal overnutrition, as seen with high-fat diet (HFD) or with increased caloric intake in early life (1)(2)(3)(4).Women who have diabetes during pregnancy and/or are obese and hyperinsulinemic are at risk of delivering macrosomic newborns (high birth weight), and both shortand long-term outcomes of macrosomic neonates are influenced by postnatal overnutrition (1-4). In high-birth-weight neonates, subsequent growth in infancy and risk of becoming obese or diabetic are directly and linearly linked-e.g., the higher the birth weight, the greater the risk of overweight and metabolic disturbances later in life (1-4). In contrast, pregnant women with severe, uncontrolled diabetes or diabetic complications, such as diabetic nephropathy and/or retinopathy, are at high risk of having a microsomic fetus (i.e., a fetus with intrauterine growth restriction (IUGR)) (5,6). Such infants may be markedly small for dates; but many develop excessive weight gain and increased fat deposition in early infancy, a proxy for neonatal overnutrition (7,8). However, the long-term outcome of IUGR offspring who experience overnutrition in early life is incomplet...

show abstract

Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The two study arms provide a comparison of conventional canola oil (low SFA, high MUFA, and good source of omega-3 polyunsaturated fatty acid [PUFA]) with an oil mixture representing the Western diet. The Western diet is characterized by high intakes of high-fat (high SFA and rich in omega-6 PUFA 23,24 ) and high-sugar foods. In our study, the fatty acid composition of the canola oil-containing foods (100% conventional canola oil) would provide 6% SFA, 62% MUFA, 32% PUFA (2:1 ratio for omega-6:omega-3 PUFA), whereas the fatty acid composition of the food items containing the oil mixture representing the Western …”

Section: Interventionmentioning

confidence: 99%

Randomized controlled trial to evaluate the effect of canola oil on blood vessel function in peripheral arterial disease: rationale and design of the Canola-PAD Study

Enns¹,

Zahradka²,

Guzman³

et al. 2014

OAJCT

View full text Add to dashboard Cite

Background: Individuals with peripheral arterial disease (PAD) are at high risk for cardiac events due to atherosclerosis. Dietary fatty acid composition has been shown to modulate blood vessel properties, but whether a diet enriched in conventional canola oil can improve clinical endpoints in PAD is not known. Purpose: To describe the rationale and design of a clinical trial testing the effect of canola oil consumption on vascular function and cardiovascular risk factors in an 8-week dietary intervention in individuals with PAD. Methods: The Canola-PAD Study was a single center, prospective, double-blind, randomized controlled trial in 50 patients over 40 years old with PAD. Participants were randomized into two groups and consumed food items containing either conventional canola oil (25 g/day) or an oil mixture representing the Western diet (25 g/day) for 8 weeks as part of their usual diet. The primary outcome was vascular function (ankle-brachial index, arterial stiffness, endothelial dysfunction, walking capacity, and cognitive function). Secondary measurements included anthropometrics, serum lipid profile and fatty acid composition, markers of inflammation and glycemic control, and serum metabolite profile. Discussion: The Canola-PAD Study uses an innovative and noninvasive approach to evaluate the effect of canola oil on clinically relevant outcomes in individuals with PAD, including arterial stiffness, walking capacity, and cognitive function. The findings will help to inform clinical guidelines and recommendations for dietary fat intake.

show abstract

“…It has been recognized as the major contributor to metabolic disturbances, hypertension, and cardiovascular diseases [5]. Also, it has been associated with an increased incidence of chronic kidney disease CKD [6]. A combination of dietary factors contributes to the impairment of renal vascularization, steatosis and inflammation, hypertension, and impaired renal hormonal regulation.…”

Section: Introductionmentioning

confidence: 99%

Effect of Western Style Diet on NLRP3 Inflammasome and its Correlation with Metabolic Syndromes

Hamid¹,

Habib²,

El-Arab³

et al. 2017

International Journal of Clinical Chemistry and Laboratory Medi

View full text Add to dashboard Cite

show abstract

The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease

Cited by 218 publications

References 157 publications

Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes

Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes

Randomized controlled trial to evaluate the effect of canola oil on blood vessel function in peripheral arterial disease: rationale and design of the Canola-PAD Study

Effect of Western Style Diet on NLRP3 Inflammasome and its Correlation with Metabolic Syndromes

Contact Info

Product

Resources

About