Cytokine gene polymorphisms affect reactivation of cytomegalovirus in patients with cancer

Cano, Pedro; Han, Faye S.; Wang, Huan Ling; Fernández-Viña, Marcelo; Han, Xiang-Yang

doi:10.1016/j.cyto.2012.07.018

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…These findings support a relationship between HCMV and carcinogenesis (26).In this study, we investigated the frequency of HCMV in tissue samples of 50 women suffering from breast cancer by using nested-PCR. Several studies indicated that HCMV infection has been linked to the malignant phenotype, particularly with glioblastoma (4).Many studies have indicated a association between HCMV with breast cancer, but they have shown different results (19).…”

Section: Discussionmentioning

confidence: 81%

Relative Frequency of Cytomegalovirus (CMV) in Tissue Samples of Women with Breast Cancer in Sanandaj, Iran.

Karimi

Hosseini

Nikkhoo³

et al. 2016

IJB

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Despite the researchers’ efforts, the cause and development of breast cancer is still incompletely understood. Currently, in some reports, human cytomegalovirus has been referred as a risk factor for breast cancer. This study aimed to determine relative frequency of cytomegalovirus in tissue samples of women with breast cancer in Sanandaj County. In this study, to determine the relative frequency of the human cytomegalovirus (CMV) 50 formalin-fixed tissues of breast cancer, which all were invasive ductal carcinoma, were studied using the nested-polymerase chain reaction. In 26 cases of breast cancer tissues (26/50), human cytomegalovirus was detected. Seventeen cases of breast cancer tissues were in a moderately differentiated stage, and nine cases had poor-differentiated stage tissues that were positive for viral DNA. At older ages (>45 years) the prevalence rate of human cytomegalovirus DNA was higher, but no significant association was seen (p=0.16). In general, due to the high prevalence of the DNA of human cytomegalovirus (58%), in this study it is assumed that human cytomegalovirus (HCMV) has a contributing role in breast cancer; although more study is required to clearly define its part in this type of cancer.

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Section: Discussionmentioning

confidence: 81%

Relative Frequency of Cytomegalovirus (CMV) in Tissue Samples of Women with Breast Cancer in Sanandaj, Iran.

Karimi

Hosseini

Nikkhoo³

et al. 2016

IJB

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“…Some studies have indicated that viral modification of the host epi genome can play an important role in GIC initiation and progression [37]. However, some other studies have demonstrated that cytokine gene polymorphism can regulate HCMV reactivation in cancer patients [38]. Specifically, it has been proposed that HCMV may increase and reinforce cancerous cell malignant properties by activating the cell survival and growth signaling pathway [39].…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus Infection Is a Risk Factor in Gastrointestinal Cancer: A Cross-Sectional and Meta-Analysis Study

Han

An³

et al. 2020

Intervirology

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Background: This study was planned to investigate the association betweenhuman cytomegalovirus (HCMV) infection and gastrointestinal cancer (GIC) risk, by undertaking a meta-analysis and case-control cross-sectional study. Summary: A cross-sectional study analysis of 160 GIC patients and 100 control subjects indicated significantly higher HCMV prevalence in GIC patients based on the HCMV IgM test. However, a similar analysis based on an IgG test revealed no significant relationship. Further meta-analysis of 11 studies, including 1,044 patients and 991 healthy subjects, displayed HCMV infection as an important risk factor for not only colorectal cancer occurrence and development based on a HCMV DNA test, but also for GIC based on a HCMV IgM test. However, the IgG test again displayed no significant relationship between HCMV infection and GIC occurrence. Key Message: Overall, our study revealed that HCMV infection is associated with an increased GIC risk. However, additional studies are warranted to elucidate the molecular mechanism underlying this association.

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“…Certain interleukins have been specifically associated with CMV reactivation in other populations. Cano et al found that alleles of three cytokines, TGFβ1, IL-4, and IL-2, were significantly associated with CMV reactivation in cancer patients [ 41 ]. In lung transplant recipients, elevated levels of IL-10 in the bronchoalveolar lavage (BAL) and/or plasma were associated with delayed CMV clearance [ 42 ].…”

Section: Methodsmentioning

confidence: 99%

Targeting CMV Reactivation to Optimize Care for Critically Ill COVID-19 Patients: A Review on the Therapeutic Potential of Antiviral Treatment

Schinas,

Moustaka,

Polyzou

et al. 2023

Viruses

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Cytomegalovirus (CMV) reactivation has been linked to adverse clinical outcomes in critically ill patients, with emerging evidence suggesting a potential connection with severe COVID-19. Mechanisms driving this association may include primary lung injury, amplification of systemic inflammation, and secondary immunosuppression. Diagnostic challenges in detecting and assessing CMV reactivation necessitate a comprehensive approach to improve accuracy and inform treatment decisions. Currently, there is limited evidence on the efficacy and safety of CMV pharmacotherapy in critically ill COVID-19 patients. Although insights from non-COVID-19 critical illness studies suggest a potential role for antiviral treatment or prophylaxis, the risks and benefits must be carefully balanced in this vulnerable patient population. Understanding the pathophysiological role of CMV in the context of COVID-19 and exploring the advantages of antiviral treatment are crucial for optimizing care in critically ill patients. This review provides a comprehensive synthesis of available evidence, emphasizing the need for additional investigation to establish the role of CMV treatment or prophylaxis in the management of severe COVID-19 and to develop a framework for future research on this topic.

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Cytokine gene polymorphisms affect reactivation of cytomegalovirus in patients with cancer

Cited by 7 publications

References 22 publications

Relative Frequency of Cytomegalovirus (CMV) in Tissue Samples of Women with Breast Cancer in Sanandaj, Iran.

Relative Frequency of Cytomegalovirus (CMV) in Tissue Samples of Women with Breast Cancer in Sanandaj, Iran.

Cytomegalovirus Infection Is a Risk Factor in Gastrointestinal Cancer: A Cross-Sectional and Meta-Analysis Study

Targeting CMV Reactivation to Optimize Care for Critically Ill COVID-19 Patients: A Review on the Therapeutic Potential of Antiviral Treatment

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