Cytokine-Induced Calgranulin C Expression in Keratocytes

Gottsch, John D.; Li, Q.; Ashraf, Frcs Saeed; O’Brien, Terrence P.; Stark, Walter J.; Liu, S.H.

doi:10.1006/clim.1998.4681

Cited by 42 publications

(20 citation statements)

References 11 publications

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“…Cornea-associated antigen (Co-Ag) has been found in the sera of patients with Mooren's ulcer [18]. In Akpek et al's and Gottsch et al's [19, 20] studies, one Co-Ag might be a protein named calgranulin C which is involved in the immune response to parasitic infections and can be also found in the corneal stroma. Therefore, calgranulin C is potentially a key factor in the pathogenesis of Mooren's ulcer.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Risk Factors of Recurrent Mooren’s Ulcer

Yang

Wang

Zhang

2017

Journal of Ophthalmology

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Purpose To investigate the clinical characteristics of Mooren's ulcer in East China and to identify the potential risk factors that affect the recurrence of Mooren's ulcer. Methods We reviewed the medical records of 95 patients (100 eyes) diagnosed with Mooren's ulcer from May 2005 to December 2014. The patients were classified into recurrent and nonrecurrent groups and followed up for 18 months. The difference between two groups was estimated. The patients in the recurrent group were subdivided according to the history of corneal infection and corneal perforation, respectively. The recurrent time in the subgroups was analyzed. Results Patients in the recurrent group were more likely to have a history of corneal infection and corneal perforation than that in the nonrecurrent groups. In patients with recurrent Mooren's ulcer, the median time to first recurrence was 130 days in the infection group, 480 days in noninfection group, and 195 days in the perforation group versus 480 days in nonperforation group. Conclusion Corneal infection and corneal perforation were associated with early recurrence of Mooren's ulcer. The tailored follow-up schedule should be used for patients with corneal infection and corneal perforation due to the high risk of recurrence.

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Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Risk Factors of Recurrent Mooren’s Ulcer

Yang

Wang

Zhang

2017

Journal of Ophthalmology

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“…This immune response will act as a long term signal to stimulate bone marrow quiescent multipotential progenitor cells and chemotaxis to the wounded limbal area to participate in the wound healing and regenerative process. It is conceivable that some factors or combinations of certain cytokines, especially IL-1 and TNF-α which are capable of stimulating keratocytes to release chemotactic factors (e.g.IL-8 and granulocyte colony stimulating factor (GM-CSF)), will activate these localized stem cells and simultaneously activate more neutrophils 40. Following activation, multipotential progenitor cells gain their ability to differentiate into vascular endothelial cells, fibroblasts, and cornea epithelial cells, therefore contributing to cornea vascularization scarring and re-epithelization.…”

Section: Discussionmentioning

confidence: 99%

The Involvement of Multipotential Progenitor Cells in Mooren's Ulcer

Lee

Kim

2005

Yonsei Med J

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The aim of this study was to assess the involvement of multipotential progenitor cells in the pathogenesis of Mooren's ulcer using immunohistochemical staining techniques. Tissue specimens were collected from 3 Mooren's ulcer patients who underwent lamellar keratectomy. Immunohistochemical staining patterns were analyzed using antibodies: CD34, c-kit, STRO-1, CD45RO, VEGF and α-SMA. Strong positive CD34, c-kit and STRO-1 cells were revealed in Mooren's ulcer specimens, especially in the superficial stroma. A few weakly expressed CD34 stroma cells were seen in normal limbal cornea but no immunoreactivity for c-kit and STRO-1 could be found. CD45RO positive T cells were found to have infiltrated in Mooren's ulcer. The immunostaining pattern of VEGF and α-SMA was closely correlated with the degree of expression and the number of CD34 positive cells. Bone marrow-derived multipotential progenitor cells may be involved in the pathogenesis of Mooren's ulcer by synergizing with other factors to amplify autoimmune destructive reactions and to contribute to the regeneration process. Specific therapeutic strategies that target the role of these cells in the disease are warranted.

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“…This will serve as a long-acting signal to stimulate bone marrow quiescent progenitor cells and chemotaxis to the wounded limbal area to participate in the wound healing and regenerative process. It is conceivable that some factors or a combination of certain inflammatory cells release cytokines, especially IL-1 and TNF-·, which are capable of stimulating keratocytes to release chemotactic factors, such as IL-8 and granulocyte colony-stimulating factor (GM-CSF), will activate migrated bone marrow cells [34]. After becoming active, these cells gain the ability to differentiate into vascular endothelial cells, fibroblasts, and cornea epithelial cells, thereby contributing to corneal vascularization, scarring and re-epithelization.…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow-Derived Cells Are Present in Mooren’s Ulcer

Chen

Kim

et al. 2004

Ophthalmic Res

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To investigate whether bone marrow-derived cells are present in Mooren’s ulcer and involved in its destructive and regenerative disease course, tissue specimens were collected from 3 eyes of 3 patients with Mooren’s ulcer that underwent lamellar keratectomy. Three normal donor limbal corneoscleras served as controls. Immunohistochemical staining patterns were analyzed by using the following antibodies: CD34 (a marker of hematopoietic progenitor cells and endothelium), c-kit (a marker of hematopoietic and stromal progenitor cells) and STRO-1 (a differentiation antigen present on bone marrow fibroblast cells and on various nonhematopoietic progenitor cells). Strong positive CD34, c-kit and STRO-1 cells were revealed in Mooren’s ulcer specimens, especially in the superficial stroma. A few weakly expressed CD34 stromal cells were seen in normal limbal cornea, but no immunoreactivity for c-kit and STRO-1 was found. Bone marrow-derived cells are present in Mooren’s ulcer and contribute to its destructive and regeneration process by synergizing with other factors. Specific therapeutic strategies that target the role of these cells in Mooren’s ulcer are anticipated.

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Cytokine-Induced Calgranulin C Expression in Keratocytes

Cited by 42 publications

References 11 publications

Clinical Characteristics and Risk Factors of Recurrent Mooren’s Ulcer

Clinical Characteristics and Risk Factors of Recurrent Mooren’s Ulcer

The Involvement of Multipotential Progenitor Cells in Mooren's Ulcer

Bone Marrow-Derived Cells Are Present in Mooren’s Ulcer

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