Cytokine producing function of type II T-helpers in transplanted kidney patients

Drannik, G.N.; Lunova, A.G; Baran, Ye.Ya; Порошина, Т. В.; Калинина, Н. А.

doi:10.1016/s0041-1345(01)02019-x

Cited by 2 publications

(1 citation statement)

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“…They control the activation and differentiation of immune effector cells and mediate cytotoxic activity of the effector cells. It has been suggested that Type I CD4 + and CD8 + T cells (Th1, Tc1) cytokines (interleukin-2, interferon- and tumor necrosis factor (TNF)-) might promote cellular rejection [1][2][3] , whereas type II CD4 + and CD8 + T cells (Th2, Tc2) cytokines (interleukin-4 and interleukin-10) might suppress graft rejection [4] . T cells stimulated via the T-cell receptors (TCRs) not only proliferate, but also undergo subsequent apoptosis by activation-induced cell death (AICD) [5,6] .…”

Section: Introductionmentioning

confidence: 99%

Correlation of CD95 and soluble CD95 expression with acute rejection status of liver transplantation

Wang

Zhang²,

Li³

et al. 2005

WJG

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AIM:To analyze the expression levels of soluble form of CD95, CD95 ligand (sCD95 and sCD95L, respectively) in plasma and CD95 expression on CD3 + cells in livertransplanted recipients with acute rejection (AR). METHODS:Peripheral blood mononuclear cells (PBMCs) were isolated from 30 clinically liver transplanted recipients. CD95 expression on CD3 + cells was quantitatively measured by two-color fluorescence activated cell sorter (FACS) analysis. Lymphocyte surface phenotypes of CD4, CD8, CD16 and CD56 were determined by flow cytometry. Plasma levels of sCD95 and sCD95L were detected by Enzyme Linked-Immuno-Sorbent Assay (ELISA). The results were compared with that from normal healthy volunteers (n = 15 individuals). respectively, P<0.01). In contrast, the plasma levels of sCD95L in liver-transplanted recipients were not significantly different from that in healthy individuals. RESULTS: CONCLUSION:The present results indicate that the increased CD95 expression on CD3 + cells and the increased levels of sCD95 in plasma may modify the immunological situation of the recipients after transplantation or represent the ongoing graft rejection.

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Section: Introductionmentioning

confidence: 99%