Cytokine profile associated with human chronic schistosomiasis mansoni

Magalhães, Ana Paula Nogueira de; Miranda, Delfin Gonzalez; Miranda, Roberval Gonzalez; Araújo, Maria Ilma; Jesús, Adriana Almeida de; Silva, Ângela; Santana, Luciana B; Pearce, Edward J.; Carvalho, Edgar M.; Jesus, Amélia Ribeiro de

doi:10.1590/s0074-02762004000900004

Cited by 19 publications

(14 citation statements)

References 19 publications

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“…In contrast, Mwatha et al (1998) found that hepatosplenic schistosomiasis is linked with low levels of IL-5. High levels of IL-5 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis compared to degrees I and II Magalhaes et al 2004).…”

Section: Discussionmentioning

confidence: 91%

Cytokine secretion profile associated with periportal fibrosis in S. mansoni-infected Egyptian patients

Talaat¹,

El-Bassiouny

Osman

et al. 2007

Parasitol Res

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Periportal fibrosis (PPF) is a major pathological consequence of S. mansoni infection. Ultrasonography is a well-established tool for diagnosis and grading of schistosomiasis-related pathology. This work is performed to study the effect of schistosomiasis mansoni infection on the cytokine secretion profile in S. mansoni-infected patients at various grades of fibrosis, as determined by ultrasonography using Cairo Working Group classification. The levels of IL-2, IL-4, IL5, IL-10, IFN-gamma, and TNF-alpha were measured in the absence of in vitro antigen stimulation and after stimulation with worm and egg antigens. Simple intestinal (INT) patients are characterized by strong proliferation to worm antigen and high levels of IL-10 and TNF-alpha compared to patients at various grades of infection. GradeII (GdII)-infected patients are characterized by higher IL-5 production than are patients with other clinical forms of the disease. Sharp reduction of almost all cytokines in response to both worm and egg antigens was detected in GdIII-infected patients. These results stressed the role of both IL-10 and TNF-alpha in the early stages of hepatic fibrosis, while IL-5 could be employed as a potential predictive marker for advanced stages. In conclusion, PPF is associated with cytokine production profiles that vary with the magnitude of the fibrosis.

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Section: Discussionmentioning

confidence: 91%

Cytokine secretion profile associated with periportal fibrosis in S. mansoni-infected Egyptian patients

Talaat¹,

El-Bassiouny

Osman

et al. 2007

Parasitol Res

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“…The role of IL-13 in S. mansoni-induced fibrosis is well established for mice (8,9,10,17,25,31,32), results which have been confirmed for humans (12,14,30). In contrast, IL-4 does not seem to be essential for the liver fibrosis induced by egg deposition (22).…”

Section: Discussionmentioning

confidence: 96%

Experimental Infection withSchistosoma mansoniin CCR5-Deficient Mice Is Associated with Increased Disease Severity, as CCR5 Plays a Role in Controlling Granulomatous Inflammation

Souza

Pereira

et al. 2011

Infect Immun

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The plasma level of the chemokine CCL3 is elevated in patients with chronic severe schistosomiasis mansoni. We have previously shown that CCL3؊/؊ mice with experimental infection showed diminished pathology and worm burden compared to those of wild-type (WT) mice. To elucidate further the role of CC chemokines during schistosomiasis mansoni infection, we evaluated the course of infection in C57BL/6J mice deficient in CCR5, one of the receptors for CCL3. The CCR5 deficiency proved to be remarkably deleterious to the host, since mortality rates reached 70% at 14 weeks postinfection in CCR5 ؊/؊ mice and 19% in WT mice. The increased lethality was not associated with an increased parasite burden, since similar numbers of eggs and adult worms were found in mice from both groups. Liver granulomas of chronically infected CCR5 ؊/؊ mice were larger and showed greater numbers of cells and collagen deposition than liver granulomas from WT mice. This was associated with higher levels of production of intereleukin-5 (IL-5), IL-13, CCL3, and CCL5 in infected CCR5 ؊/؊ mice than in infected WT mice. Moreover, at 8 weeks after infection, just before changes in pathology and mortality, the numbers of FoxP3-positive cells were lower in liver granulomas of CCR5 ؊/؊ mice than in WT mice. In conclusion, the CCR5 deletion is deleterious to mice infected with Schistosoma mansoni, and this is associated with enhanced fibrosis and granulomatous inflammation.

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“…Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for 1 year following initial assessment and who developed more serious fibrosis during this period. 104 In a study of hepatosplenic schistosomiasis mansoni, there was no significant difference in the mean serum concentrations of IL-10 and IL-13 between the different categories of hepatosplenic disease. 105 3.9.…”

Section: Cytokinesmentioning

confidence: 94%

The chronic enteropathogenic disease schistosomiasis

Olveda¹,

Olveda

McManus

et al. 2014

International Journal of Infectious Diseases

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Schistosomiasis is a chronic enteropathogenic disease caused by blood flukes of the genus Schistosoma. The disease afflicts approximately 240 million individuals globally, causing approximately 70 million disability-adjusted life years lost. Chronic infections with morbidity and mortality occur as a result of granuloma formation in the intestine, liver, or in the case of Schistosoma haematobium, the bladder. Various methods are utilized to diagnose and evaluate liver fibrosis due to schistosomiasis. Liver biopsy is still considered the gold standard, but it is invasive. Diagnostic imaging has proven to be an invaluable method in assessing hepatic morbidity in the hospital setting, but has practical limitations in the field. The potential of non-invasive biological markers, serum antibodies, cytokines, and circulating host microRNAs to diagnose hepatic fibrosis is presently undergoing evaluation. This review provides an update on the recent advances made with respect to gastrointestinal disease associated with chronic schistosomiasis.

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Cytokine profile associated with human chronic schistosomiasis mansoni

Cited by 19 publications

References 19 publications

Cytokine secretion profile associated with periportal fibrosis in S. mansoni-infected Egyptian patients

Cytokine secretion profile associated with periportal fibrosis in S. mansoni-infected Egyptian patients

Experimental Infection withSchistosoma mansoniin CCR5-Deficient Mice Is Associated with Increased Disease Severity, as CCR5 Plays a Role in Controlling Granulomatous Inflammation

The chronic enteropathogenic disease schistosomiasis

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