Cytokine profile in lung transplant recipients with <i>Aspergillus</i> spp colonization

Herrera, Sabina; Gohir, Wajiha; Foroutan, Farid; Aguilar, Claire; Juvet, S.; Martinu, T.; Kumar, Deepali; Humar, Atul; Rotstein, Coleman; Keshavjee, S.; Singer, L.G.; Husain, Shahid

doi:10.1111/tid.13060

Cited by 3 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both limitations must be taken into consideration when interpreting the statistical significance of findings in situations where the interquartile ranges overlap (e.g., neutrophil and eosinophil counts). While our results agree with earlier studies, there remains an urgent need to confirm them in a larger cohort [ 26 , 27 , 35 , 36 ]. In addition, this study did not perform a joint analysis of the explored biomarkers.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Chronic Lung Allograft Dysfunction Is Associated with Increased Levels of Cell-Free Mitochondrial DNA in Bronchoalveolar Lavage Fluid of Lung Transplant Recipients

Schneck

Askevold

Rath

et al. 2022

JCM

View full text Add to dashboard Cite

Chronic Lung Allograft Dysfunction (CLAD) is a life-threatening complication that limits the long-term survival of lung transplantation patients. Early diagnosis remains the basis of efficient management of CLAD, making the need for distinctive biomarkers critical. This explorative study aimed to investigate the predictive power of mitochondrial DNA (mtDNA) derived from bronchoalveolar lavages (BAL) to detect CLAD. The study included 106 lung transplant recipients and analyzed 286 BAL samples for cell count, cell differentiation, and inflammatory and mitochondrial biomarkers, including mtDNA. A receiver operating curve analysis of mtDNA levels was used to assess its ability to detect CLAD. The results revealed a discriminatory pro-inflammatory cytokine profile in the BAL fluid of CLAD patients. The concentration of mtDNA increased in step with each CLAD stage, reaching its highest concentration in stage 4, and correlated significantly with decreasing FEV1. The receiver operating curve analysis of mtDNA in BAL revealed a moderate prediction of CLAD when all stages were grouped together (AUROC 0.75, p-value < 0.0001). This study has found the concentration mtDNA in BAL to be a potential predictor for the early detection of CLAD and the differentiation of different CLAD stages, independent of the underlying pathology.

show abstract

Section: Discussionsupporting

confidence: 89%

“…However, since MIP1α levels were only slightly elevated at CLAD stage 1, it would not be suitable as a CLAD biomarker. This observation is consistent with its primary functions in the early inflammatory response and not in later chronic inflammatory states [36,37].…”

Section: Discussionsupporting

confidence: 89%

Chronic Lung Allograft Dysfunction Is Associated with Increased Levels of Cell-Free Mitochondrial DNA in Bronchoalveolar Lavage Fluid of Lung Transplant Recipients

Schneck

Askevold

Rath

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

Identifying host microRNAs in bronchoalveolar lavage samples from lung transplant recipients infected with Aspergillus

Gohir¹,

Klement

Singer

et al. 2020

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

Age difference of patients with and without invasive aspergillosis: a systematic review and meta-analysis

Shekhova,

Salazar,

Da Silva Dantas

et al. 2024

BMC Infect Dis

View full text Add to dashboard Cite

Background Invasive Aspergillosis (IA) is a life-threatening fungal disease with significant mortality rates. Timely diagnosis and treatment greatly enhance patient outcomes. This study aimed to explore the association between patient age and the development of IA, as well as the potential implications for risk stratification strategies. Methods We searched National Center for Biotechnology Information (NCBI) databases for publications until October 2023 containing age characteristics of patients with and without IA. A random-effects model with the application of inverse-variance weighting was used to pool reported estimates from each study, and meta-regression and subgroup analyses were utilized to assess sources of heterogeneity. Results A systematic review was conducted, resulting in the inclusion of 55 retrospective observational studies with a total of 13,983 patients. Meta-analysis revealed that, on average, patients with IA were approximately two and a half years older (95% Confidence Interval [CI] 1.84–3.31 years; I2 = 26.1%) than those without the disease (p < 0.0001). No significant moderators could explain the observed heterogeneity in age difference. However, subgroup analysis revealed that age differences were more pronounced within particular patient groups compared to others. For example, patients with and without IA who had primary severe lung infections exhibited a greater difference in mean age than other patient cohorts. Conclusions Further research, such as individual patient data meta-analysis, is necessary to better understand the potential relationship between increasing age and the likelihood of IA. Improved risk stratification strategies based on patient age could potentially enhance the early detection and treatment of IA, ultimately improving patient outcomes.

show abstract

Cytokine profile in lung transplant recipients with Aspergillus spp colonization

Cited by 3 publications

References 38 publications

Chronic Lung Allograft Dysfunction Is Associated with Increased Levels of Cell-Free Mitochondrial DNA in Bronchoalveolar Lavage Fluid of Lung Transplant Recipients

Chronic Lung Allograft Dysfunction Is Associated with Increased Levels of Cell-Free Mitochondrial DNA in Bronchoalveolar Lavage Fluid of Lung Transplant Recipients

Identifying host microRNAs in bronchoalveolar lavage samples from lung transplant recipients infected with Aspergillus

Age difference of patients with and without invasive aspergillosis: a systematic review and meta-analysis

Contact Info

Product

Resources

About