Cytokine profiles in patients with toxoplasmic lymphadenitis in the setting of pregnancy

Pomarès, Christelle; Holmes, Tyson H.; Estran, Remy; Press, Cynthia; Ramirez, Raymund; Talucod, Jeanne; Maecker, Holden T.; Rosenberg-Hasson, Yael; Montoya, José G.

doi:10.1016/j.cyto.2016.09.021

Cited by 3 publications

(3 citation statements)

References 46 publications

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“…Second, the cytokine distributions of patients and controls in both studies were heterogeneous and overlapping, even for cytokines having significantly different mean serum levels. This is not unlike what is seen for cytokines in other disorders; cytokine findings in different individuals with the same disorder often vary 30–35 . Third, the frequency of various GDD symptoms in the 2 studies differs.…”

Section: Discussionmentioning

confidence: 87%

“…This is not unlike what is seen for cytokines in other disorders; cytokine findings in different individuals with the same disorder often vary. [30][31][32][33][34][35] Third, the frequency of various GDD symptoms in the 2 studies differs. For example, all GDD patients in the current study had bone pain and burning skin pain compared with 63% and 58%, respectively, in the previous study.…”

Section: Discussionmentioning

confidence: 98%

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Acute Chelation Therapy‐Associated Changes in Urine Gadolinium, Self-reported Flare Severity, and Serum Cytokines in Gadolinium Deposition Disease

et al. 2021

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Objectives: The aim of this study was to determine the following in patients who have undergone magnetic resonance imaging with gadolinium-based contrast agents (GBCAs) and meet the proposed diagnostic criteria for gadolinium deposition disease (GDD): (1) the effectiveness of chelation therapy (CT) with intravenous Ca-diethylenetriaminepentaacetic acid in removing retained gadolinium (Gd) and factors affecting the amount removed; (2) the frequency of CT-induced Flare, that is, GDD diagnostic symptom worsening, and factors affecting Flare intensity; (3) whether, as reported in a separate cohort, GDD patients' serum cytokine levels differ significantly from those in healthy normal controls and change significantly in response to CT; and (4) whether urine Gd, Flare reaction, and serum cytokine findings in GDD patients are mimicked in non-ill patients described as having gadolinium storage condition (GSC). Materials and Methods: Twenty-one GDD subjects and 3 GSC subjects underwent CT. Patients provided pre-CT and post-CT 24-hour urine samples for Gd content determination along with pre-CT and 24-hour post-CT serum samples for cytokine analysis. Patients rated potential Flare 24 hours after CT. Pre-CT and post-CT 24-hour urine Gd analyses and Luminex serum cytokine assays were performed blind to patients' GDD and GSC status and all other data except age and sex. Serum cytokine levels in a healthy normal control group of age-and sex-matched subjects drawn from Stanford influenza vaccination studies were measured once, contemporaneously with those of GDD and GSC patients, using the same Luminex assay. Results: Urine Gd amounts increased post-CT by 4 times or more after 87% of the 30 CT sessions. The most important factors appeared to be the time since the last GBCA dose and the cumulative dose received. Urine Gd amounts for GDD and GSC patients fell in the same ranges. All GDD patients, and no GSC patient, reported a Flare 24 hours post-CT. Linear regression found that Flare intensity was significantly predicted by a model including pre-and post-CT Gd amounts and the number of GBCA-enhanced magnetic resonance imaging. Post-CT, multiple cytokines showed strong positive relationships with GDD patients' Flare intensity in multivariable models. The pre-CT serum levels of 12 cytokines were significantly different in GDD patients compared with healthy flu vaccine controls. The small number of GSC patients precluded analogous statistical testing. Post-CT, GDD patients' serum levels of 20 cytokines were significantly decreased, and 2 cytokines significantly increased. These cytokines did not exhibit the same change pattern in the 3 GSC patients. The small number of GSC patients precluded statistical comparisons of GSC to GDD patients' results. Conclusions: In this preliminary study, 24-hour urine Gd content increased markedly and similarly in GDD and GSC patients after Ca-diethylenetriaminepentaacetic acid CT. Post-CT Flare reaction developed only in GDD patients. The current study is the second finding significantly different ...

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 98%

Acute Chelation Therapy‐Associated Changes in Urine Gadolinium, Self-reported Flare Severity, and Serum Cytokines in Gadolinium Deposition Disease

et al. 2021

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“…Additionally, levels of VCAM1, CCL2, and CCL5 are lower in pregnant than in non-pregnant women. 193 The levels of ICAM1, CXCL9, CXCL10, MCSF, and TNFβ were upregulated in acutely toxoplasmosis-infected Colombian pregnant women. Whereas, the levels of Eotaxin (Et), TGFβ, TNFα, IFNγ, IL2, IL4, IL15, CXCL1, and stem cell factor (SCF) were down-regulated in pregnant American acute cohorts.…”

Section: ) Toxoplasmosis and Pregnancymentioning

confidence: 95%

Immune response against toxoplasmosis—some recent updates RH: Toxoplasma gondii immune response

Sana

Rashid

et al. 2022

Int J Immunopathol Pharmacol

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Aims Cytokines, soluble mediators of immunity, are key factors of the innate and adaptive immune system. They are secreted from and interact with various types of immune cells to manipulate host body’s immune cell physiology for a counter-attack on the foreign body. A study was designed to explore the mechanism of Toxoplasma gondii ( T. gondii) resistance from host immune response. Methods and results The published data on aspect of host (murine and human) immune response against T. gondii was taken from Google scholar and PubMed. Most relevant literature was included in this study. The basic mechanism of immune response starts from the interactions of antigens with host immune cells to trigger the production of cytokines (pro-inflammatory and anti-inflammatory) which then act by forming a cytokinome (network of cytokine). Their secretory equilibrium is essential for endowing resistance to the host against infectious diseases, particularly toxoplasmosis. A narrow balance lying between Th1, Th2, and Th17 cytokines (as demonstrated until now) is essential for the development of resistance against T. gondii as well as for the survival of host. Excessive production of pro-inflammatory cytokines leads to tissue damage resulting in the production of anti-inflammatory cytokines which enhances the proliferation of Toxoplasma. Stress and other infectious diseases (human immunodeficiency virus (HIV)) that weaken the host immunity particularly the cellular component, make the host susceptible to toxoplasmosis especially in pregnant women. Conclusion The current review findings state that in vitro harvesting of IL12 from DCs, Np and MΦ upon exposure with T. gondii might be a source for therapeutic use in toxoplasmosis. Current review also suggests that therapeutic interventions leading to up-regulation/supplementation of SOCS-3, IL12, and IFNγ to the infected host could be a solution to sterile immunity against T. gondii infection. This would be of interest particularly in patients passing through immunosuppression owing to any reason like the ones receiving anti-cancer therapy, the ones undergoing immunosuppressive therapy for graft/transplantation, the ones suffering from immunodeficiency virus (HIV) or having AIDS. Another imortant suggestion is to launch the efforts for a vaccine based on GRA6Nt or other similar antigens of T. gondii as a probable tool to destroy tissue cysts.

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Association between lymphadenopathy after toxoplasmosis seroconversion in pregnancy and risk of congenital infection

Donadono

Saccone

Sarno

et al. 2021

Eur J Clin Microbiol Infect Dis

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Cytokine profiles in patients with toxoplasmic lymphadenitis in the setting of pregnancy

Cited by 3 publications

References 46 publications

Acute Chelation Therapy‐Associated Changes in Urine Gadolinium, Self-reported Flare Severity, and Serum Cytokines in Gadolinium Deposition Disease

Acute Chelation Therapy‐Associated Changes in Urine Gadolinium, Self-reported Flare Severity, and Serum Cytokines in Gadolinium Deposition Disease

Immune response against toxoplasmosis—some recent updates RH: Toxoplasma gondii immune response

Association between lymphadenopathy after toxoplasmosis seroconversion in pregnancy and risk of congenital infection

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