Cytokine profiles in serum and peritoneal fluid from infertile women with and without endometriosis

Abstract

The elevated levels of MCP-1, IL-6, and IL-8 in peritoneal fluid but not serum may indicate the importance of local macrophage activating factors in the pathogenesis of endometriosis.

Experimental immunology Non-invasive diagnosis of endometriosis based on a combined analysis of four plasma biomarkers

“…Increased serum IL-6 levels observed in patients with minimal-mild endometriosis in our study are in line with findings of some reports [18][19][20] but depart from others that found no value for serum IL-6 in the diagnosis of endometriosis at any stage [21,22] and from yet others that reported slightly elevated serum IL-6 levels in controls [23][24][25]. Additionally, it is worthwhile to note that serum IL-6 was the only marker that was constantly elevated in all our comparison groups (endometriosis group, minimalmild endometriosis group and moderate-severe endometriosis group).…”

“…had increased plasma concentrations of inflammatory cytokines. Comparable TNF-α [20,[23][24][25]] levels were previously reported in women with and without endometriosis. However, other investigators reported elevated levels of TNF-α and Epo in endometriosis patients compared with controls [13,18,26].…”

Tumor Necrosis Factor-α Regulates Inflammatory and Mesenchymal Responses via Mitogen-Activated Protein Kinase Kinase, p38, and Nuclear Factor κB in Human Endometriotic Epithelial Cells

“…Primary cultures of endometriotic epithelial cells have been shown to produce IL-6, IL-8, and TNF-␣ (Bergqvist et al, 2000;Luk et al, 2005). MCP-1 and RAN-TES have also been found elevated in peritoneal fluid of women with endometriosis, and previously, their production has been reported to originate from stromal cells (Bersinger et al, 2006;Kalu et al, 2007). Results from our studies clearly demonstrate an effect of TNF-␣, a primary effector of inflammatory responses, to increase production of IL-6, IL-8, MCP-1, and GM-CSF from 12Z epithelial endometriotic cells.…”

Innovative approach in assessing the role of neurogenesis, angiogenesis, and lymphangiogenesis in the pathogenesis of external genital endometriosis

“…Adhesion occurs by the activation of cell adhesion molecule sICAM-1, oxidative stress, and inflammatory processes which are supported by activated immune cells [19].…”