Cytokines and Chemokines in Irritant Contact Dermatitis

eri, insan vücudunun en dış bariyeri olduğu için çevreden gelen kimyasal ve fiziksel faktörlerden en çok etkilenen yapıdır. Günü-müzde kullanılan birçok ilaç, kozmetik ve diğer çeşitli kimyasal içe-rikli ürünlerin topik maruziyetinin klinik sonucu olarak temas dermatiti tablosu ortaya çıkmaktadır. Temas dermatiti patofizyolojik mekanizmasına göre temel olarak iki tiptedir. İrritan temas dermatiti, derinin doğal immü-nitesini aktive eden ksenobiyotiklerin, fiziksel ve kimyasal özelliklerinin sitotoksik etkilerine bağlıdır. Allerjik temas dermatiti ise deri inflamasyonuna aracılık eden efektör T-hücrelerine bağlı olarak antijen spesifik kazanılmış immünite aktivasyonunu gerekmektedir.

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“…İrritasyonda deride yanma, acı, sızlama, batma, ağrı ve kaşıntı oluşurken, allerjinin en önemli belirtisi kaşıntıdır. 4 …”

Section: Kli̇ni̇k Olarak İrri̇tan Temas Dermati̇ti̇ İle Allerji̇k Temas Derunclassified

Irritant Contact Dermatitis and Allergic Contact Dermatitis: A Comparison of Mechanism, Clinical Results and Test Methods: Review

Arancioğlu¹,

Ülker²,

Karakaya³

2015

Turkiye Klinikleri J Pharm Sci

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“…Fibroblasts also stimulate active mediators such as CXCL8, CXCL1, and CCL2. This leads to migration of Langerhans cells out of the epidermis [23,24] and the simultaneous upregulation of adhesion molecules that result in recruitment of more immune cells into the skin [25].…”

Section: Cytokine Cascadementioning

confidence: 99%

Irritant Contact Dermatitis: Mechanisms to Repair

Eberting¹

2014

J Clin Exp Dermatol Res

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Irritant contact dermatitis is an extremely common condition resulting from epidermal exposure to any number of skin irritants. Upon contact with skin irritants, the epidermis develops many identifiable problems including specific epidermal lipid deficiencies, elevated epidermal pH with concomitant suppression of epidermal lipid production, pHdependent susceptibility to infection, inflammation, and aberrant calcium gradients. By addressing these problems simultaneously, and through irritant avoidance, the treatment of irritant contact dermatitis can be maximized.

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“…The skin barrier damage triggers the activation of the innate immunity and the production of pro-inflammatory cytokines [3]. Keratinocytes constitute 95% of the epidermis cell matrix and once activated, keratinocytes play an important role in skin inflammatory and immunological reactions by the production of several cytokines and chemokines [4]. Many irritants can cause the expression of IL1A after stimulation, which subsequently induces the expression of other cytokines and chemokines such as TNF-α, IL-6, CXCL8, and others.…”

Section: Introductionmentioning

confidence: 99%

Insight into the Mechanism of SDS Irritation on Human Skin Keratinocytes by Examination of Changes in Gene Expression

Wang¹,

An²,

Zhao³

et al. 2016

Am. J. Biomed. Sci.

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Sodium dodecyl sulfate (SDS) is widely used as an irritant. Inflammatory and immune related cytokines/ chemokines are released by keratinocytes following SDS irritation. However, a specific effect of SDS on keratinocytes and the mechanism of skin irritation caused by SDS have not been investigated. To explore the irritant mechanism of SDS on keratinocytes, a gene microarray was used to detect the changes in gene expression after treating keratinocytes with SDS for different amounts of time. After 0.5 h and 1 h SDS exposure, there were changes mainly in genes in the rheumatoid arthritis pathway (CCL5, IL-6, FOS, CSF1, and HLA-DPB1) and TNF signaling pathway (TNF, CSF2, CXCL3, TNFAIP3, PTGS2, CXCL8, CCL20, and PIK3CA) to cause a pro-inflammatory reaction as well as autoimmune activation. After treating with SDS for 2 h and 4 h, there were changes in the expression of genes (LIF, PIM1, MAP3K8, CCNA1, RUNX1, and CYP1) that are related to cell apoptosis and cancerization. This was related to changes in transcriptional activity in the cancer and tryptophan metabolism pathway. Overall, SDS irritation caused different changes in gene expression over time, which altered the state of keratinocytes affecting processes of inflammation, autoimmune response, cell apoptosis, and cancerization. These results provide insight into the irritation process of SDS and provide reference for the future evaluation of skin irritation.

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Cytokines and Chemokines in Irritant Contact Dermatitis

Cited by 100 publications

References 60 publications

Irritant Contact Dermatitis and Allergic Contact Dermatitis: A Comparison of Mechanism, Clinical Results and Test Methods: Review

Irritant Contact Dermatitis and Allergic Contact Dermatitis: A Comparison of Mechanism, Clinical Results and Test Methods: Review

Irritant Contact Dermatitis: Mechanisms to Repair

Insight into the Mechanism of SDS Irritation on Human Skin Keratinocytes by Examination of Changes in Gene Expression

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