Cytokines and hormones as possible links between endocrinosenescence and immunosenescence

Straub, Rainer H.; Miller, Luitpold E.; Schölmerich, Jürgen; Zietz, B.

doi:10.1016/s0165-5728(00)00296-4

Cited by 96 publications

(67 citation statements)

References 30 publications

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“…Despite a general immunosenescence (decrease of immunological parameters such as phagocytosis, cell trafficking, etc. ), some increased immune functions like IL-4, IL-6, and TNF-α production could be observed (Straub et al, 2000). All these examples clearly demonstrate that GCs not only suppress immune function but have also the potential to enhance certain parts of the immune system.…”

Section: Glucocorticoids and Inflammation: Challenging The Dogmamentioning

confidence: 78%

Glucocorticoids and Central Nervous System Inflammation

2002

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Glucocorticoids (GCs) are well known for their anti-inflammatory and immunosuppressive properties in the periphery and are therefore widely and successfully used in the treatment of autoimmune diseases, chronic inflammation, or transplant rejection. This led to the assumption that GCs are uniformly anti-inflammatory in the periphery and the central nervous system (CNS). As a consequence, GCs are also used in the treatment of CNS inflammation. There is abundant evidence that an inflammatory reaction is mounted within the CNS following trauma, stroke, infection, and seizure, which can augment the brain damage. However an increasing number of studies indicate that the concept of GCs being universally immunosuppressive might be oversimplified. This article provides a review of the current literature, showing that under certain circumstances GCs might fail to have anti-inflammatory effects and sometimes even enhance inflammation. Journal of NeuroVirology (2002) 8, 513-528.

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Section: Glucocorticoids and Inflammation: Challenging The Dogmamentioning

confidence: 78%

Glucocorticoids and Central Nervous System Inflammation

2002

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“…In recent years it has become evident that there is a strong correlation between animal behaviour, stress and the neuro-endocrine and immune systems [2][3][4]. Therefore, unfavourable environmental conditions could lowered homeostatic functions, such as the immune response and in particular the innate immune system [5] and the health status of animals [6].…”

Section: Introductionmentioning

confidence: 99%

Effect of Genotype and Husbandry System on Blood Parameters, Oxidative and Native Immune Status: Welfare and Implications on Performance of Organic Laying Hens

Mugnai¹

2011

TOVSJ

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Abstract:The aim of the present work was to compare the effect of organic production vs standard cage system on welfare and performance of a pure breed (Ancona) vs a commercial strain (Brown Hy-Line) of laying hens through a multifunctional approach (behaviour, tonic immobility, feathers score, antioxidant status of the body, blood parameters, innate immunity and mortality). The trial was carried out in farm of the Dpt. of Applied Biology (University of Perugia), where 17-weeks-old females of Ancona breed (n=200) and Brown Hy-Line (n=200) were divided in 2 homogenous groups of 100 birds each and assigned to cage or organic rearing systems.The genotype of the hens affected in a degree which depends on rearing system almost all the variables. The feeding and resting activities were higher in caged whereas moving activities were higher in organic hens and especially in Ancona birds. Social relationships showed genotype and rearing system effects being higher in Brown Hy-Line hens particularly when reared in cage. The TI duration was affected by genotype and rearing system being the immobility time longer in Brown Hy-Line. The plumage condition showed a great rearing system effect and genotype effects was observed only between organic groups where Ancona hens showed the better feathers condition. Regarding native immune status serum bactericidal activity showed the highest values in organic hens and mainly in Ancona ones. On the contrary, lysozyme showed greater value in caged hens. The haptoglobin value was lower in organic Ancona group, the same hens showed about 30% greater reactive oxygen substances, but accompanied by highest the antioxidant power. Organic rearing system, mainly in the Ancona hens, induced the highest red blood cells, haemoglobin and hematocrite values. Lymphocytes were higher in Organic birds thus reducing the H/L ratio in Organic hens. As expected, organic birds showed the worst feed efficiency and percentage of deposition, but the lowest mortality rate. In conclusion, on the basis of all these information together with the low mortality rate, Ancona hens showed the better welfare status, mainly when they were organically reared.

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“…IL-6 is an inflammatory mediator and may be involved in the pathogenesis of numerous age-associated pathologies such as various lymphoproliferative disorders [64]. An increase in IL-6 serum levels appears to be necessary to stimulate the hypothalamus [65].…”

Section: Cytokinesmentioning

confidence: 99%

The role of exercise on the innate immunity of the elderly

Cristaldi

Vinci

Malaguarnera

2007

Eur Rev Aging Phys Act

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The increased life span in human population has shown that some diseases, as infections, cancer and autoimmune phenomena, occur more frequently in the elderly than in the younger. We describe the ageing process involving the innate immune system and the improvement given by moderate physical activity. In addition, we discuss the altered neutrophil granulocytes function, the role of macrophages and natural killer cells, besides the influence of cytokines and secretory IgA. The acquired information help us to explain how these changes could favor the onset of diseases in the elderly and how they may boost their immune function.

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Cytokines and hormones as possible links between endocrinosenescence and immunosenescence

Cited by 96 publications

References 30 publications

Glucocorticoids and Central Nervous System Inflammation

Glucocorticoids and Central Nervous System Inflammation

Effect of Genotype and Husbandry System on Blood Parameters, Oxidative and Native Immune Status: Welfare and Implications on Performance of Organic Laying Hens

The role of exercise on the innate immunity of the elderly

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