Cytokines and Other Mediators in Alopecia Areata

Gregoriou, Stamatis; Papafragkaki, Dafni; Kontochristopoulos, George; Rallis, Eustathios; Kalogeromitros, D.; Rigopoulos, Dimitrios

doi:10.1155/2010/928030

Cited by 116 publications

(118 citation statements)

References 37 publications

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“…MHC class I is strongly expressed in AA lesions, along with MHC II. Classical upregulators of MHC I expression like interferon (IFN)-γ [31], tumor necrosis factor (TNF)-α, and interleukin (IL)-1β [63] are enhanced in AA lesions and down-modulators of MHC I expression (IL-10, αMSH, IGF-1, TGFβ) are modified in AA lesions as well [18,31,64]. Specific genetic polymorphisms of HLA-DQB1 and HLA-DRB1, which belong to the HLA class II beta chain paralogs, strongly correlate to increased probability of AA onset [65][66][67].…”

Section: Immune Privilege Collapse In Alopecia Areatamentioning

confidence: 99%

The role of lymphocytes in the development and treatment of alopecia areata

Guo

Cheng

Shapiro

et al. 2015

Expert Review of Clinical Immunology

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SummaryAlopecia areata (AA) development is associated with both innate and adaptive immune cell activation, migration to peri-and intra-follicular regions, and hair follicle disruption. Both CD4+ and CD8+ lymphocytes are abundant in AA lesions; however, CD8+ cytotoxic T lymphocytes are more likely to enter inside hair follicles, circumstantially suggesting that they have a significant role to play in AA development. Several rodent models recapitulate important features of the human autoimmune disease and demonstrate that CD8+ cytotoxic T lymphocytes are fundamentally required for AA induction and perpetuation. However, the initiating events, the selfantigens involved, and the molecular signaling pathways, all need further exploration. Studying CD8+ cytotoxic T lymphocytes and their fate decisions in AA development may reveal new and improved treatment approaches.

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Section: Immune Privilege Collapse In Alopecia Areatamentioning

confidence: 99%

The role of lymphocytes in the development and treatment of alopecia areata

Guo

Cheng

Shapiro

et al. 2015

Expert Review of Clinical Immunology

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“…TNF, although discovered as a result of its antitumor activity in the beginning, has now been found having functions in tumor initiation, progression, and metastasis [28]. TNF-α, synthesized in epidermal keratinocytes was shown to be a very potent inhibitor of follicle proliferation and plays a major role in the pathogenesis of alopecia areata (AA) [29]. Intradermal injection of TNF-α caused a significant high number of apoptotic cells in the epidermis [30].…”

Section: Gene Expression Analysis (Real-time Qpcr)mentioning

confidence: 99%

Evaluating Antiinflammatory and Antiandrogenic Effects of Garden Cress (Lepidium sativum L.) in HaCaT cells

Türkoğlu¹,

Kılıç²,

Pekmezci³

et al. 2018

Rec.Nat.Prod.

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Lepidium sativum L. (Brassicaceae) (Ls), garden cress, is an edible herb that is botanically related to watercress and mustard, sharing their peppery, tangy flavor and aroma. The various parts of the plant have been traditionally used for many respiratory, rheumatologic, cardiovasculary, metabolic, and gastrointestinal disorders. Several studies were performed showing its antiinflammatory, anticarcinogenic, antiproliferative as well as tissue protective effects. In all of these studies the positive effects of Ls were concluded as the result of its antioxidant features due to the polyphenols and organosulphur compounds. In this study, we investigated the molecular basis of antiinflammatory, antiproliferative, antimitotic and antiandrogenic effects of Ls leaf extract in HaCaT cells. The gene expression levels of vascular endothelial growth factor (VEGF), tumor necrosis factoralpha (TNF-α), interleukin 1-alpha (IL-1α), and 5 alpha-reductase type II (SRD5A2) were studied. Gene expressions were determined by RT-qPCR analysis. Fold change results of the gene expression analyses showed that the plant extract caused statistically significant downregulation of VEGF (0.2167, p<0.0001), p = 0.0262), and SRD5A2 (0.0567, p<0.0001). The fold change for IL-1α was 0.6900 and this result was not statistically significant (p = 0.1522). These preliminary results may partially explain the clinical success of Ls in the traditional medicine. Considering these results, topical application of Lepidium sativum extract may be beneficial for inflammatory, androgen dependent disorders of the skin.

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“…Akut emosyonel stres, olas›l›kla k›l folikülleri etraf›nda yerleflmifl olan Tip 2 β kortikotropin serbestlefltirici hormon reseptörleri-ni aktive ederek yo¤un lokal enflamasyona ve saç dökülmesi-ne yol açmaktad›r 28 . Ayr›ca alopesi areata (AA) alan›ndaki k›l folikülleri etraf›nda Substans P (SP)'nin belirgin olarak artt›¤› ve bunun strese yan›t olarak periferik sinir uçlar›ndan salg›lan-d›¤› bildirilmektedir [28][29] . Bu moleküler araflt›rmalar AA'l› hastalarda stres hormonlar›n›n enflamasyon üzerinde etkili oldu¤u-nu düflündürürken baz› araflt›rmac›lar stresin o denli etkin olmad›¤›n› ileri sürmektedir.…”

Section: Alopesi Areataunclassified

Psikonöroimmünoloji ve Multifaktöryel Psikodermatolojik Hastalıklar

Altunay¹

2012

Turkderm

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ÖzetPsikonöroimmünoloji beyin, nöro-endokrin sistem ve immün sistem aras›nda nöropeptitler ve hormonlar arac›l›¤›yla kurulan dinamik iliflkileri araflt›ran yeni bir çal›flma disiplinidir. Mental ve psiflik faktörlerin immün sistemi ve sonuçta genel sa¤l›¤› ne flekilde etkiledi¤ini aç›klamay› hedeflemektedir. Deri immün ifllevlerin yürütülmesinde kritik bir role sahip bir organd›r; iç ve d›fl stresörlere yan›t veren ve birbiriyle son derece uyumlu çal›flan hücre topluluklar›n› içermektedir. Derideki immün sistem hücre-lerinin ve ifllevlerinin etkilenmesiyle ortaya ç›kan hastal›klarda psiflik stres beyin, sinir sistemi ve endokrin sistemi de kapsayan karmafl›k olaylar örüntüsü yaratmakta, hastal›¤›n ortaya ç›k›fl›, seyri ve tedaviye yan›t›n› ödemli ölçüde etkilemektedir. Bu makalede psikojen faktörlerin deriyi nas›l etkiledi¤i ve hangi sistemleri harekete geçirdi¤i ve psiflik stresin etkiledi¤i belli bafll› dermatolojik hastal›klar›n gözden geçirilmesi amaçlanm›flt›r. SummaryPsychoneuroimmunology is a new discipline which searches dynamic relationship between mind, neuroendocrin system and immune system that is organized via neuropeptides and hormones. It aims to investigate and explain how mental and psychic factors affect immune system and ultimately general health. The skin is an organ which has a critical immune function, and also has cell populations to respond to both intrinsic and extrinsic stressors in a coordinated manner. Psychic stress creates an array of complex events involving the brain, nervous system and immune system in cutaneous diseases in which immun system cells and their functions are affected. It has been aimed to review how psychic stress influences the skin and which systems are driven and also which main dermatologic diseases are involved in this context. (Turkderm 2010; 44 Suppl 1: 10-5) Key Words: Psychoneuroimmunology, psychosomatic diseases, psoriasis, vitiligo, alopecia areata GiriflPsikolojik ve sosyal faktörler genel olarak hastal›klar›n ortaya ç›k›fl›n›, geliflmesini ve iyileflmesini genel olarak psikososyal yap›lanma ve sa¤l›kla iliflkili davran›fllar olmak üzere iki flekilde etkiler: Psikososyal yap›lanma mental sa¤l›k, kiflilik ve duygudurum özellikleri ile sosyal iliflkileri kapsar; kiflinin yaflam olaylar› ve stresörleri alg›lama ve yorumlama tarz›n› flekillendirirken stresör-lere verece¤i yan›t› belirler. Sa¤l›kla ilgili davran›fllar ise egzersiz, beslenme, sigara ve alkol kullan›m› gibi davran›fllar› kapsar ve psikososyal etmenlerle birlikte kiflinin sa¤l›¤›n› etkiler. Biyopsikososyal modele göre tüm bu etmenler bireyin genetik veya yap›sal karakteristikleri ile etkileflime girerek belli hastal›klara zemin haz›rlar (diyatez). Buna göre hastal›¤a uygun genetik predispozisyon stresli olayla karfl›laflana dek gizli kal›r. Biyopsikososyal model psikosomatik t›bb›n temel kavramlar›ndan olup bireyin psikolojisi ile beden sa¤l›¤› aras›ndaki karfl›l›kl› etkileflimi anlamada yarar sa¤la-maktad›r [1][2][3][4] . Psikonöroimmünoloji sinir sistemi, endokrin sistem (hormonlar) ve imm...

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Cytokines and Other Mediators in Alopecia Areata

Cited by 116 publications

References 37 publications

The role of lymphocytes in the development and treatment of alopecia areata

The role of lymphocytes in the development and treatment of alopecia areata

Evaluating Antiinflammatory and Antiandrogenic Effects of Garden Cress (Lepidium sativum L.) in HaCaT cells

Psikonöroimmünoloji ve Multifaktöryel Psikodermatolojik Hastalıklar

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