Cytokines, chemokines and growth factors in wound healing

Behm, Barbara; Babilas, Philipp; Landthaler, Míchael; Schreml, Stephan

doi:10.1111/j.1468-3083.2011.04415.x

Cited by 346 publications

(306 citation statements)

References 84 publications

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“…35,36 Briefly, the inflammatory phase immediately follows wounding, serving to stop bleeding in the wound bed via platelet aggregation and fibrin clot formation. This is followed by invasion of neutrophils and mast cells that follow a chemotactic gradient to clear the wound of dead cells, debris, and residual ECM.…”

Section: Chronic Skin Woundsmentioning

confidence: 99%

Activity of mesenchymal stem cells in therapies for chronic skin wound healing

2013

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Section: Chronic Skin Woundsmentioning

confidence: 99%

Activity of mesenchymal stem cells in therapies for chronic skin wound healing

2013

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“…The healing process requires the interaction between various tissues and many cell types, including neutrophils, macrophages, keratinocytes, fibroblasts, and endothelial cells (Barrientos et al, 2008;Behm et al, 2012). Alterations in any of these steps can lead to a delay or inability in dermal proper wound healing, causing pathological manifestations such as keloids and hypertrophic scars (Gauglitz et al, 2011;Seifert & Mrowietz, 2009).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, antimicrobial and wound healing properties ofStruthanthus vulgaris

Vittorazzi

Endringer

Andrade

et al. 2015

Pharmaceutical Biology

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Context: Struthanthus vulgaris (Vell.) Mart. (Loranthaceae) has been widely used in traditional medicine in Brazil to bathe wounds. Objective: The objective of this study is to investigate the in vitro wound healing effects, together with the antioxidant and antimicrobial activities of S. vulgaris leaf and branch extracts. Material and methods: Ethanol leaf and branch extracts of S. vulgaris were investigated at 1-100 mg/ml concentrations in the scratch assay after 14 h. Antioxidant activity was investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay, and the antibacterial activity was tested at concentrations up to 1000 mg/ml against Gram-positive and Gramnegative bacteria by the microdilution test after 24 h. The total phenolic and flavonoid contents were determined by colorimetric methods. Results: Struthanthus vulgaris leaf and branch extracts at 100 mg/ml concentration stimulated migration and proliferation of fibroblasts and enhanced cell numbers by 56.2% and 18.6%, respectively. Antioxidant activity exhibited IC 50 values of 24.3 and 18.9 mg/ml for the leaf and branch extracts, respectively. The ethanol leaf extract showed antimicrobial activity against the Gram-positive Staphylococcus mutans and Staphylococcus aureus bacteria, exhibiting minimum inhibitory concentration values of 125 and 500 mg/ml, respectively. An appreciable total phenolic content in the leaves (813.6 ± 2.7 mg/g) and branches (462.8 ± 9.6 mg/g), and relatively low concentration of flavonoids in the leaves (13.3 ± 4.3 mg/g) and branches (1.9 ± 0.2 mg/g), was detected. Discussion and conclusion: The antioxidant and antibacterial activities, together with the strong ability to stimulate proliferation and migration of fibroblasts, provide some support for the traditional use of S. vulgaris.

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“…TGF-β cause migration of leukocytes into the injured tissue. As a result, monocytes transform into macrophages and clear the area of debris and itself to release TGF-β and other growth factors, which in turn help in the formation of granulation tissue (Behm et al, 2012).…”

Section: Wound Healing Mechanisms Of Medicinal Plantsmentioning

confidence: 99%