Medicinal plants with wound healing potential

Firdous, Sayeed Mohammed; Sautya, Dippayan

doi:10.3329/bjp.v13i1.32646

Cited by 37 publications

(28 citation statements)

References 62 publications

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“…However, it did not show any activity against the burned wound. Therefore, the extract only increases fibrosis in excisional ulcers [ 134 , 135 ]. Notably, in Mexico no studies have been conducted to corroborate the wound healing activity of Ephedra species.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties

et al. 2020

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Ephedra is one of the largest genera of the Ephedraceae family, which is distributed in arid and semiarid regions of the world. In the traditional medicine from several countries some species from the genus are commonly used to treat asthma, cold, flu, chills, fever, headache, nasal congestion, and cough. The chemical constituents of Ephedra species have been of research interest for decades due to their contents of ephedrine-type alkaloids and its pharmacological properties. Other chemical constituents such as phenolic and amino acid derivatives also have resulted attractive and have provided evidence-based supporting of the ethnomedical uses of the Ephedra species. In recent years, research has been expanded to explore the endophytic fungal diversity associated to Ephedra species, as well as, the chemical constituents derived from these fungi and their pharmacological bioprospecting. Two additional aspects that illustrate the chemical diversity of Ephedra genus are the chemotaxonomy approaches and the use of ephedrine-type alkaloids as building blocks in organic synthesis. American Ephedra species, especially those that exist in Mexico, are considered to lack ephedrine type alkaloids. In this sense, the phytochemical study of Mexican Ephedra species is a promising area of research to corroborate their ephedrine-type alkaloids content and, in turn, discover new chemical compounds with potential biological activity. Therefore, the present review represents a key compilation of all the relevant information for the Ephedra genus, in particular the American species, the species distribution, their ecological interactions, its ethnobotany, its phytochemistry and their pharmacological activities and toxicities, in order to promote clear directions for future research.

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Section: Pharmacological Propertiesmentioning

confidence: 99%

A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties

et al. 2020

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“…In adults, wound healing process includes: (1) rapid homeostasis and inflammation; (2) proliferation; and (3) remodeling. 29,30 Hemostasis begins shortly after the injury, with vasoconstriction and fibrin clots forming. The clot and tissue around the wound release proinflammatory cytokines and growth factors such as TGF-β, PDGF, fibroblast growth factor, and EGF.…”

Section: Discussionmentioning

confidence: 99%

Determination the Effectiveness of a selected formulations of Iranian Traditional Medicine â€œUshaq poulticeâ€ (ammoniacum gum ointment) on Wound Healing: an experimental study

Abdevand

Siahpoosh

Malayeri

et al. 2020

J. Contemp. Med. Sci.

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Objective: The purpose of this study was to evaluate the therapeutic effects of ammonium gum ointment on wound healing in the animal model. Method: 32 male Wistar rats were selected; then in non-infectious condition, two full-thickness wounds with 8 mm in diameter were created bilaterally on shaved skin in 1.5 cm from the dorsal midline and randomly divided into four groups, untreated group, phenytoin cream treated group, base ointment (sesame oil and wax) treated group and Ammonicuma Gum Ointment (AGO) treated group. The animals received these medicines once daily. On days 5, 7, 10, 12 and 14 wound area was measured. On days 7 and 14, blood samples were taken, and serum level of growth factors (EGF, PDGF, VEGF, and TGF-B) were measured. Skin samples used for hematoxylin-eosin and trichrome staining. Skin tensile strength and hydroxyproline content of skin tissues also measured. Results: The percentage of wound healing after 14 days of treatment was significantly increased in the group receiving AGO (P˂0.05). Hydroxyproline content of repaired tissue and tensile strength increased considerably in this group (P˂0.001). Growth factors were significantly increased in animals treated with AGO compared to control groups (EGF P˂0.05; PDGF P˂0.001; VEGF P˂0.001; TGF-B P˂0.05). Histological data showed that the topical application of AGO compared to other groups resulted in positive effects on enhance neovascularization and granulation, increased wound healing rate, and decreased wound size. Conclusion: The topical application of an ointment containing ammoniacum gum can help speed up the process of wound healing.

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“…As a consequence of ethnobotanical survey, many species of plants and herbs with wound healing activities have been identified in Africa and other developing countries. The use of medicinal plants in wound management and care involves disinfection, debridement, and the provision of adequate environment for natural healing process [49]. It is assumed that ingredients from medicinal plants are less toxic and have fewer side effects compared with orthodox therapeutic agents; hence, the increased and renewed interest in the use and application of medicinal plants in the wound healing process both in diabetic and non-diabetic conditions.…”

Section: The Role Of Medicinal Plants In Wound Healing In Diabetic Modelmentioning

confidence: 99%

Medicinal plants and their effects on diabetic wound healing

Oguntibeju

2019

Vet World

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Wounds have a serious negative impact on the health-care economy of a country, especially on the economy of developing countries where resources are poor and funding is very limited. It is presumed that about 80% of people living in developing countries use traditional medicines which are majorly prepared from medicinal plants to meet their primary health-care needs. Due to the large reservoir of medicinal plants and adequate traditional knowledge on wound healing, many people in Africa and other developing countries use medicinal plants in the treatment of diabetic wounds and related complications. Wound healing in the external and internal biological organs involves a series of complex overlapping processes which demand excellent communication between cells. It is an orderly and highly controlled process characterized by hemostasis, inflammation, proliferation, and remodeling. Diabetes is a global health problem predicted to rise to over 642 million by 2040. The propelling factor responsible for the increase in morbidity and mortality of diabetes is linked to vascular complications as well as the failure of the wound healing processes in diabetic state. Different approaches have been adopted in the treatment of diabetic wounds, and medicinal plants are certainly one of those approaches that have drawn global attention. In this review paper, the effects of medical plants on wound healing in diabetic state as well as factors affecting wound healing and the mechanism of action of medicinal plants are examined.

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Medicinal plants with wound healing potential

Abstract: of Hibiscus rosa sinensis L (Malvaceae) in Wistar albino rats. Indian J Pharmacol. 2012; 44: 694-98.Biswas TK, Pandit S, Chakrabarti S, Banerjee S, Poyra N, Seal T. Evaluation of Cynodon dactylon for wound healing activity.

Cited by 37 publications

References 62 publications

A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties

A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties

Determination the Effectiveness of a selected formulations of Iranian Traditional Medicine â€œUshaq poulticeâ€ (ammoniacum gum ointment) on Wound Healing: an experimental study

Medicinal plants and their effects on diabetic wound healing

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Medicinal plants with wound healing potential

Abstract: of Hibiscus rosa sinensis L (Malvaceae) in Wistar albino rats. Indian J Pharmacol. 2012; 44: 694-98.Biswas TK, Pandit S, Chakrabarti S, Banerjee S, Poyra N, Seal T. Evaluation of Cynodon dactylon for wound healing activity.

Cited by 37 publications

References 62 publications

A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties

A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties

Determination the Effectiveness of a selected formulations of Iranian Traditional Medicine â€œUshaq poulticeâ€ (ammoniacum gum ointment) on Wound Healing: an experimental study

Medicinal plants and their effects on diabetic wound healing

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Determination the Effectiveness of a selected formulations of Iranian Traditional Medicine â€œUshaq poulticeâ€ (ammoniacum gum ointment) on Wound Healing: an experimental study