Cytokines in asthma and obesity in children

Krasteva, Niya A.; Shentov, Boiko; Elkina, S. I.

doi:10.1183/13993003.congress-2018.pa1303

Cited by 2 publications

(2 citation statements)

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“…Although obesity can be characterised as an energy storage disorder, it is also associated with low-intensity inflammation, independent of the association between insulin resistance and sub-acute inflammation (Inadera, 2008;Singer and Lumeng, 2017;Mãrginean et al 2020). Many of the illnesses comorbid with obesity (e.g., osteoarthritis, skin disorders, asthma, even cognitive impairment) have an inflammatory component (Vendrell and Chacon, 2013;Krasteva et al, 2018;Stefanadi et al, 2018;Wang and He, 2018;Buie et al, 2019;Suhett et al, 2021), including type 2 diabetes mellitus (T2DM), dyslipidemia, atherosclerosis, and other cardiovascular diseases (CVD) (Herder et al, 2007;Yeste et al, 2007;Carolan et al, 2014;Lund et al, 2020). The discovery of adipocytokines synthesised mainly by adipocytes further suggests an attractive mechanism for molecular signalling between obese adipose tissue and other organ systems.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Cytokine IFNγ, IL-6, and IL-10 Association with Childhood Obesity

Kupča

Jurka

Marksa

et al. 2021

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Childhood obesity carries a high risk of serious life-threatening cardiometabolic diseases in adulthood, which are associated with low-grade inflammation. The aim of the present study was to measure serum cytokine concentrations in obese children recruited during endocrinology consultations and compared to lean control the results. Blood serum concentrations of interferon gamma (IFNγ), IL-1β, Interleukin 6 IL-6, IL-10, and TNF-α were analysed applying Luminex xMap technology with Millipore reagent kits. Statistical analyses were performed using t-test comparisons and Spearman correlations. Obese children had highly significant increased levels of circulating IFNγ (p < 0.0001), IL-6 (p < 0.0001), and IL-10 (p < 0.0001), compared to lean controls. IL-1β and TNFα levels, however, were not elevated. Significant correlation of serum cytokines to per cent excess body mass was only observed with IL-6 (rs = 0.21, p < 0.03), although IL-1β (rs = 0.18, p < 0.08) results were suggestive of a trend. A significant association of obesity in childhood with serum concentrations of IFNγ, IL-6, and IL-10 is consistent with a role for low-grade inflammatory processes early in the aetiology of this disease. IL-6 further appears to be a candidate cytokine for assessment of degree of sub-acute inflammation associated with excess weight in the young.

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Section: Introductionmentioning

confidence: 99%

Inflammatory Cytokine IFNγ, IL-6, and IL-10 Association with Childhood Obesity

Kupča

Jurka

Marksa

et al. 2021

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…Hence, many chemokines and cytokines, including IL-4 which mediates important proinflammatory functions in asthma, IL-5 which is associated with eosinophil development and its expression declines with corticosteroids, and IL-21 which enhances neutrophil production during asthma, may have roles in the severity of pediatric asthma. 9-13 Nevertheless, deciphering their pulmonary impacts is a challenging point of research. This study aimed to show the possible roles of leptin, IL-4, IL-5 and IL-21 in a link between obesity and asthma in children.…”

Section: Introductionmentioning

confidence: 99%

Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21?

et al. 2019

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BACKGROUND: Adiposity is associated with high serum levels of adipokines and chemokines which are possibly implicated in a co-existence of obesity and asthma.OBJECTIVES: Elucidate the possible roles of leptin, interleukin (IL)-4, IL-5 and IL-21 in linking obesity with childhood asthma.DESIGN: Cross-sectional, analytical.SETTING: Population of schoolchildren in a small Saudi city.SUBJECTS AND METHODS: The study included a representative sample of Saudi schoolchildren grouped as obese asthmatics, non-obese asthmatics, or obese nonasthmatics, with nonobese nonasthmatics as a control group. An asthma control test was done for the asthmatic groups.MAIN OUTCOME MEASURES: Serum levels of leptin, IL-4, IL-5, and IL-21.SAMPLE SIZE: 345 male schoolchildren with a mean (SD) age of 13.0 (2.3) years.RESULTS: Median serum leptin concentrations in obese asthmatics were significantly higher than in nonobese asthmatics (P<.001). Uncontrolled asthmatics also had significantly higher leptin levels than controlled asthmatic children (P<.002). Leptin levels were weakly but significantly correlated with the cytokines IL-4, IL-5, and IL-21.CONCLUSIONS: Leptin may contribute to a link between obesity and childhood asthma. Differences in IL-21 levels between nonobese and obese asthmatics suggest that the co-existence of asthma and obesity increased IL-21 levels. Leptin plus some proinflammatory cytokines especially IL-21 may be potential predictors for asthma control in children.LIMITATIONS: Blood sampling at different stages of asthma might influence cytokine expression.CONFLICT OF INTEREST: None.

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Cytokines in asthma and obesity in children

Cited by 2 publications

References 0 publications

Inflammatory Cytokine IFNγ, IL-6, and IL-10 Association with Childhood Obesity

Inflammatory Cytokine IFNγ, IL-6, and IL-10 Association with Childhood Obesity

Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21?

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