Cytokines in rotator cuff degeneration and repair

Bedi, Asheesh; Maak, Travis G.; Walsh, Christopher P.; Rodeo, Scott A.; Grande, Dan; Dines, David M.; Dines, Joshua S.

doi:10.1016/j.jse.2011.09.020

Cited by 96 publications

(75 citation statements)

References 111 publications

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“…31 This explains the relatively high percentage of patients with failure of healing or recurrent RCTs after repair. The pathogenesis results from mechanical and biological factors.…”

Section: Discussionmentioning

confidence: 99%

Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide) fibrous membranes

Zhao¹,

Zhao²,

Dong³

et al. 2014

IJN

108

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Clinically, rotator cuff tear (RCT) is among the most common shoulder pathologies. Despite significant advances in surgical techniques, the re-tear rate after rotator cuff (RC) repair remains high. Insufficient healing capacity is likely the main factor for reconstruction failure. This study reports on a basic fibroblast growth factor (bFGF)-loaded electrospun poly(lactide-co-glycolide) (PLGA) fibrous membrane for repairing RCT. Implantable biodegradable bFGF–PLGA fibrous membranes were successfully fabricated using emulsion electrospinning technology and then characterized and evaluated with in vitro and in vivo cell proliferation assays and repairs of rat chronic RCTs. Emulsion electrospinning fabricated ultrafine fibers with a core-sheath structure which secured the bioactivity of bFGF in a sustained manner for 3 weeks. Histological observations showed that electrospun fibrous membranes have excellent biocompatibility and biodegradability. At 2, 4, and 8 weeks after in vivo RCT repair surgery, electrospun fibrous membranes significantly increased the area of glycosaminoglycan staining at the tendon–bone interface compared with the control group, and bFGF–PLGA significantly improved collagen organization, as measured by birefringence under polarized light at the healing enthesis compared with the control and PLGA groups. Biomechanical testing showed that the electrospun fibrous membrane groups had a greater ultimate load-to-failure and stiffness than the control group at 4 and 8 weeks. The bFGF–PLGA membranes had the highest ultimate load-to-failure, stiffness, and stress of the healing enthesis, and their superiority compared to PLGA alone was significant. These results demonstrated that electrospun fibrous membranes aid in cell attachment and proliferation, as well as accelerating tendon–bone remodeling, and bFGF-loaded PLGA fibrous membranes have a more pronounced effect on tendon–bone healing. Therefore, augmentation using bFGF–PLGA electrospun fibrous membranes is a promising treatment for RCT.

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“…31 This explains the relatively high percentage of patients with failure of healing or recurrent RCTs after repair. The pathogenesis results from mechanical and biological factors.…”

Section: Discussionmentioning

confidence: 99%

Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide) fibrous membranes

Zhao¹,

Zhao²,

Dong³

et al. 2014

IJN

108

View full text Add to dashboard Cite

show abstract

“…Furthermore, bony in-growth formation, which is fundamental for functional restoration of the tendon, is nonexistent in allografts, restricting their use. 12,[20][21][22] Common harvest sources of autografts include the tensor fascia lata, the biceps long head tendon, the hamstring tendon, the patellar tendon, and the Achilles tendon. Because these grafts originate from the person's own body, they are regarded as the gold-standard choice of graft.…”

Section: Classification Of Patch Graftsmentioning

confidence: 99%

Patch Augmentation for Massive Rotator Cuff Tears

Yoon¹

2017

Clinics in Shoulder and Elbow

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Rotator cuff tears commonly affect the shoulder joints. Despite developments in surgical techniques and instrumentation, the treatment of massive rotator cuff tears remains challenging. The problems associated with rotator cuff repairs, such as inferior mechanical properties and high retear rates are yet to be solved. Recently, patch augmentation has been suggested as an alternative treatment because it can reinforce mechanical properties at the initial stage of healing and reduce gap formation. The purpose of this article was to comprehensively summarize the concepts and the consensus surrounding patch augmentation and evaluate the clinical and anatomical outcomes after patch augmentation for massive rotator cuff tears. (Clin Shoulder Elbow 2017;20(2):105-112)

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“…Cellular biological therapies have the potential to improve this healing process, and studies with cytokines and transcription factors, such as scleraxis, are being developed with the aim of creating a therapy that improves the repair of ruptures and decreases the rate of failure [7,55].…”

Section: Cell Biological Therapiesmentioning

confidence: 99%

“…The ruptures of the hood are the most common musculotendinous ruptures [4], and the prevalence of massive ruptures ranges from 10% to 40% and increases with age [2,[5][6][7]. The first studies to use the term "solid rupture" date from the decades of 70, 80 [1].…”

Section: Introductionmentioning

confidence: 99%

Rotary Hood Massive Break Solutions? Massive Rotator Cuff Tear Solutions?

Panzina¹,

Gutierres²

2017

MOJOR

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Aim: review the current literature on options of treatment for massive rotator cuff tear Sources of data:The information was researched on the Pubmed using the following keywords: "massive", "rotator", "cuff ", "tear", "treatment". The survey was restricted to articles in english or portuguese, with less than 5 years. After selection 55 articles were used. Summary of data:Massive Rotator Cuff Tear is an orthopaedic challenge with a technically hard repair and a recurrence rate distinctively higher than the smaller tears rate. Its treatment has a high failure rate, which is influenced by factors such as patient's age, fatty degeneration and muscular retraction. The treatment choice should be based on patient's age, functional demands and symptoms. Conclusion:There are several options for the treatment of rotator cuff tears. Conservative treatment achieved good results in many patients, leaving many of them assymptomatic and with satisfactory function. The arthroscopic débridement, subacromial decompression and bicips tenotomy have as main objective the symptomatic relief and may be indicated in elderly patients with low functional demands, whose major complaint is pain. Repair should be tried specially in young symptomatic high-demand patients. Both hemiarthroplasty as reverse arthroplasty may be indicated in massive rupture and cuff arthropathy, being reverse arthroplasty the most effective treatment, although the not negligible mid-term complication rate.

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Cytokines in rotator cuff degeneration and repair

Cited by 96 publications

References 111 publications

Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide) fibrous membranes

Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide) fibrous membranes

Patch Augmentation for Massive Rotator Cuff Tears

Rotary Hood Massive Break Solutions? Massive Rotator Cuff Tear Solutions?

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