Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study

Roubenoff, Ronenn; Parise, Helen; Payette, Hélène; Abad, Leslie W.; D’Agostino, Ralph B.; Jacques, Paul F.; Wilson, Peter W.F.; Dinarello, Charles A.; Harris, Tamara B.

doi:10.1016/j.amjmed.2003.05.001

Cited by 352 publications

(243 citation statements)

References 24 publications

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“…An evolving definition of inflammation in gerontology is low-grade activation of the innate immune system, leading to chronic production of inflammatory mediators. Inflammatory processes in general have been implicated as predictors of or contributors to chronic diseases and conditions of aging (117), such as cardiovascular disease (118), low cognitive performance (119), osteoarthritis and dementia (120), frailty (121,122), muscle wasting (123), physical performance (123,124), disability (125,126) and mortality (127)(128)(129). These associations have been…”

Section: The Biological Explanationmentioning

confidence: 99%

Fatigue in older adults: an early indicator of the aging process?

2010

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Section: The Biological Explanationmentioning

confidence: 99%

Fatigue in older adults: an early indicator of the aging process?

2010

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“…Resulting height loss could affect normal functioning of the respiratory and gastrointestinal systems, (13) which in turn might lead to early satiety, poor nutritional status, and weight loss. (13) Height loss also appears to be related to sarcopenia, (32) which is defined as the loss of skeletal muscle mass and strength with aging and is associated with weight loss (40)(41)(42)(43) and increased mortality. (33)(34)(35) We found increased mortality associated with marked HL due to CHD or stroke and respiratory diseases, but no increased cancer mortality.…”

Section: Journal Of Bone and Mineral Researchmentioning

confidence: 99%

Height loss starting in middle age predicts increased mortality in the elderly

Masunari

Fujiwara

Kasagi

et al. 2011

Journal of Bone and Mineral Research

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The purpose of this study was to determine the mortality risk among Japanese men and women with height loss starting in middle age, taking into account lifestyle and physical factors. A total of 2498 subjects (755 men and 1743 women) aged 47 to 91 years old underwent physical examinations during the period 1994 to 1995. Those individuals were followed for mortality status through 2003. Mortality risk was estimated using an age-stratified Cox proportional hazards model. In addition to sex, adjustment factors such as radiation dose, lifestyle, and physical factors measured at the baseline-including smoking status, alcohol intake, total cholesterol, blood pressure, and diagnosed diseases-were used for analysis of total mortality and mortality from each cause of death. There were a total of 302 all-cause deaths, 46 coronary heart disease and stroke deaths, 58 respiratory deaths including 45 pneumonia deaths, and 132 cancer deaths during the follow-up period. Participants were followed for 20,787 person-years after baseline. Prior history of vertebral deformity and hip fracture were not associated with mortality risk. However, more than 2 cm of height loss starting in middle age showed a significant association with all-cause mortality among the study participants (HR ¼ 1.76, 95% CI 1.31 to 2.38, p ¼ 0.0002), after adjustment was made for sex, attained age, atomic-bomb radiation exposure, and lifestyle and physical factors. Such height loss also was significantly associated with death due to coronary heart disease or stroke (HR ¼ 3.35, 95% CI 1.63 to 6.86, p ¼ 0.0010), as well as respiratory-disease death (HR ¼ 2.52, 95% CI 1.25 to 5.22, p ¼ 0.0130), but not cancer death. Continuous HL also was associated with all-cause mortality and CHD-or stroke-caused mortality. Association between height loss and mortality was still significant, even after excluding persons with vertebral deformity. Height loss of more than 2 cm starting in middle age was an independent risk factor for cardiovascular and respiratory-disease mortality among the elderly, even after adjusting for potential risk factors. ß

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“…55,56 For SHIP, inverse associations between IGF-I or IGFBP3 levels and mortality from all causes, CVD or cancer in men, and between IGFBP3 and all-cause mortality in women, were found. 57 Interestingly, for FTO, reports exist that the increase in mortality cannot be explained solely by its FTO effect on obesity and diabetes.…”

Section: Igf-i and Obesitymentioning

confidence: 99%

The growth hormone—IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania

Rosskopf

Schwahn²,

Neumann

et al. 2010

Int J Obes

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Context: Risk alleles of the fat mass-and obesity-associated gene (FTO) are related not only to increased body mass index (BMI) values but also to mortality. It was speculated that cellular effects of the FTO gene affect most organs, especially their ability to maintain or regenerate proper function when afflicted by various diseases. FTO is highly expressed in the hypothalamus and also in the pituitary gland. The decrease in growth hormone (GH) secretion is known to cause a decrease in lean body mass in older subjects. Objective: We hypothesized an association of rs9926289 with insulin-like growth factor (IGF)-I. Design and setting: Cross-sectional data from the Study of Health in Pomerania, a population-based study in the northeastern part of Germany, were used. Participants: For the final analyses, 3882 subjects aged 20-79 years were available. Main outcome measures: Continuous IGF-I, low IGF-I according to clinically meaningful age-and gender-specific reference values, and BMI were used as outcome measures. Results: Over all age groups, a statistically significant relationship between FTO and IGF-I was found. In subjects younger than 55 years of age, homozygous carriers of the FTO risk allele exhibited lower serum IGF-I levels adjusted for 5-year age groups, gender and IGF-I binding protein 3 levels (linear regression, coefficient ± s.e. for FTO AA genotype:À8.6 ± 2.8; P ¼ 0.002). Further adjustments for obesity and diabetes did not suspend this association (coefficient:-7.8; P ¼ 0.005). As expected, the FTO AA genotype effect on BMI was reduced from 0.76 to 0.62 kg m À2 by including IGF-I. No relationship between FTO and IGF-I levels was found in subjects aged 55 years or older (À2.7±2.4; P ¼ 0.260 for FTO AA genotype adjusted for age, gender and IGF-I binding protein 3 levels). Conclusion: We propose that the GHFIGF-I axis is a mediator for the relationship between FTO and BMI.

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Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study

Cited by 352 publications

References 24 publications

Fatigue in older adults: an early indicator of the aging process?

Fatigue in older adults: an early indicator of the aging process?

Height loss starting in middle age predicts increased mortality in the elderly

The growth hormone—IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania

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