Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma

Farahani, Rahim; Sherkat, Roya; Ganjalikhani‐Hakemi, Mazdak; Eskandari, Nahid; Yazdani, Reza

doi:10.4103/2277-9175.133249

Cited by 44 publications

(14 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL-9 is associated with the development of airway hyper-responsiveness (AHR) and airway remodeling 3031. In the present study, administration of anti-IL-9 antibody reduced the sneezing response.…”

Section: Discussionmentioning

confidence: 49%

Anti-Interleukin-9 Antibody Increases the Effect of Allergen-Specific Immunotherapy in Murine Allergic Rhinitis

Shin

Kim

et al. 2017

Allergy Asthma Immunol Res

View full text Add to dashboard Cite

PurposeInterleukin (IL)-9 induces allergic responses; however, the roles of anti-IL-9 antibody in the induction of tolerance remain unclear. This study investigated the effects of anti-IL-9 antibody on oral tolerance (OT) in a mouse model of allergic rhinitis (AR).MethodsBALB/c mice were divided into 4 groups: the control, AR, OT, and OT with anti-IL-9 antibody (OT+IL9AB) groups. Ovalbumin (OVA) was used for sensitization and challenge. Mice in the OT and OT+IL9AB groups were fed OVA for immunotherapy. During immunotherapy, OT+IL9AB mice were injected with anti-IL-9 antibody. Allergic symptoms, tissue eosinophil counts, and serum OVA-specific immunoglobulin E (IgE) were measured. The mRNA expressions of cytokines and transcription factors of T cells of nasal mucosa were determined by real-time polymerase chain reaction (PCR). The protein levels of GATA3, ROR-γt, and Foxp3 in nasal mucosa were determined by Western blot. CD4+CD25+Foxp3+ T cells in the spleen were analyzed by flow cytometry.ResultsAdministration of anti-IL-9 antibody decreased allergic symptoms, OVA-specific IgE levels, and eosinophil counts. In addition, it inhibited T-helper (Th) 2 responses, but had no effect on Th1 responses. Protein levels of ROR-γt and mRNA levels of PU.1 and ROR-γt were reduced by anti-IL-9 antibody. Anti-IL-9 antibody increased Foxp3 and IL-10 mRNA expression, Foxp3 protein, and induction of CD4+CD25+Foxp3+ T cells.ConclusionsAnti-IL-9 antibody decreased allergic inflammation through suppression of Th2 and Th17 cells. Anti-IL-9 antibody enhanced the tolerogenic effects of regulatory T cells. These results suggest that anti-IL-9 antibody might represent a potential therapeutic agent for allergen immunotherapy in patients with uncontrolled allergic airway disease.

show abstract

Section: Discussionmentioning

confidence: 49%

Anti-Interleukin-9 Antibody Increases the Effect of Allergen-Specific Immunotherapy in Murine Allergic Rhinitis

Shin

Kim

et al. 2017

Allergy Asthma Immunol Res

View full text Add to dashboard Cite

show abstract

“…In addition, Th17 cells may have a role in severe asthma and chronic obstructive pulmonary disease [15, 17, 18]. …”

Section: Introductionmentioning

confidence: 99%

Innate lymphoid cells and cytokines of the novel subtypes of helper T cells in asthma

Sherkat

Yazdani

Ganjalikhani‐Hakemi

et al. 2014

Asia Pacific Allergy

Self Cite

View full text Add to dashboard Cite

BackgroundIn this study, the expression of interleukin-9 (IL-9), IL-17, IL-22, and IL-25 genes that might be the potential predisposing factors for asthma as well as count of innate lymphoid cells (ILCs) as another source of inflammatory cytokines have been evaluated.ObjectiveThe aim of this study was to evaluate the expression of newly identified helper T cells signature cytokines and amount of ILCs.MethodsBlood and sputum samples from 23 patients with moderate to severe asthma and 23 healthy volunteers were collected. The types of allergens to which our patients were sensitive were defined using immunoblotting method. Gene expression of studied cytokines was evaluated using quantitative transcription-polymerase chain reaction and ILCs were counted by the flow cytometry method.ResultsIn this research, the gene expressions of IL-9, IL-17, IL-22, and IL-25 were significantly higher in asthmatics, especially in the severe form of the disease. This increase was even higher in serum samples compared with sputum samples. Counting ILCs revealed their increase in comparison with normal people.ConclusionWe showed the importance of IL-25, IL-22, IL-17, and IL-9 cytokines in patients with asthma as their expression levels are increased and these increase are correlated with the severity of the disease. We also showed that the increased amount of ILCs in asthmatics could confirm their potential role in the immunopathogenesis of asthma as another source of inflammatory cytokines.

show abstract

“…Recent data have implicated Th25 in the immunopathogenesis of skin diseases, namely, coccidioidomycosis, chronic mucocutaneous candidiasis, and lepromatous leprosy ( Fig. 4 and Table 1) (178,(218)(219)(220)(221)(222).…”

Section: T Lymphocytesmentioning

confidence: 99%

“…In particular, they have focused on cytokine IL-9, or on anti-inflammatory profiles such as that observed for Th25 lymphocytes, whose cytokine IL-25 (IL-17E) is related to humoral immune responses and is therefore ineffective against intracellular infectious agents. IL-25 belongs to the IL-17 family, and unlike other members of this family such as IL-17A and IL-17F, it inhibits Th1 and Th17 cytokine production (178,213,218,220,(369)(370)(371)(372). NF-B activation is induced by IL-25 and triggers the expression of IL-4, IL-5, IL-9, and immunoglobulin E, as well as the degranulation of mast cells against extracellular pathogens (218).…”

Section: Overview Of the Relationship Between Skin Immune System And mentioning

confidence: 99%

Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases

Quaresma

2019

Clin Microbiol Rev

View full text Add to dashboard Cite

SUMMARY The skin is an organ harboring several types of immune cells that participate in innate and adaptive immune responses. The immune system of the skin comprises both skin cells and professional immune cells that together constitute what is designated skin-associated lymphoid tissue (SALT). In this review, I extensively discuss the organization of SALT and the mechanisms involved in its responses to infectious diseases of the skin and mucosa. The nature of these SALT responses, and the cellular mediators involved, often determines the clinical course of such infections. I list and describe the components of innate immunity, such as the roles of the keratinocyte barrier and of inflammatory and natural killer cells. I also examine the mechanisms involved in adaptive immune responses, with emphasis on new cytokine profiles, and the role of cell death phenomena in host-pathogen interactions and control of the immune responses to infectious agents. Finally, I highlight the importance of studying SALT in order to better understand host-pathogen relationships involving the skin and detail future directions in the immunological investigation of this organ, especially in light of recent findings regarding the skin immune system.

show abstract

Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma

Cited by 44 publications

References 68 publications

Anti-Interleukin-9 Antibody Increases the Effect of Allergen-Specific Immunotherapy in Murine Allergic Rhinitis

Anti-Interleukin-9 Antibody Increases the Effect of Allergen-Specific Immunotherapy in Murine Allergic Rhinitis

Innate lymphoid cells and cytokines of the novel subtypes of helper T cells in asthma

Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases

Contact Info

Product

Resources

About