Cytologic features of angioleiomyoma: Cytologic‐histologic study of 10 cases

Abstract

Fine-needle aspiration (FNA) features in 10 angioleiomyomas (ALM) were evaluated and correlated to histological features and clinical data. The tumors developed in the skin or subcutaneous tissue of the lower extremities (eight), the shoulder (one), and the lower arm (one). Eight tumors were painful or tender. Cytological specimens showed moderate or sparse cellularity. The most frequent findings were uniform spindle cells, seen in nine smears. In eight of these, the spindle cells were admixed with smooth muscle cells and fragments of collagenous tissue in varying proportions. The occurrence of macrophages and fat cells was less specific, being present in three of nine smears. One aspirate contained some "ganglion-like" cells and a multinucleated giant cell. Smears from ALM are not sufficiently characteristic to permit a histotype diagnosis, but together with typical clinical data (painful or tender nodule) may help to exclude other skin or subcutaneous lesions.

Angioleiomyoma: a clinical, pathological and radiological review

“…Duhig and Ayer (12) suggest that proliferation of smooth muscle within a haemangioma produces a vascular leiomyoma and that further proliferation produces a simple leiomyoma. Most authors agree that (1,4,9) vascular leiomyoma arises from veins. These lesions may be hamartomas.…”

“…Minor trauma (7–10), venous stasis and hormonal changes especially that of oestrogen have been proposed as aetiological features. The presence of chronic inflammatory cell infiltrates (1,2) in some lesions support the venous stasis theory.…”

Leiomyoma of the Foot and Ankle: A Case Series

“…3,6,14 Histologically, the tumor consists of uniform, compact, spindle-shaped smooth muscle cells, with cylindrical nuclei surrounding vascular channels. 16 They are further characterized as either solid, cavernous, or venous types. 3 Of the 8 specimens, 4 were consistent with the subclassification of angioleiomyoma.…”

Clinical Experience with Treatment of Angioleiomyoma

“…Pain and/or tenderness may be the presenting feature in 45% to 70% of all cases [1,2,3,4,5,6,7]. Patient ages in the symptomatic group and in the asymptomatic group did not differ significantly.…”