Cytological Characteristics of Pulmonary Pleomorphic and Giant Cell Carcinomas

Hiroshima, Kenzo; Dosaka‐Akita, Hirotoshi; Usuda, Katsuo; Ogura, Shinji; Kusunoki, Yoko; Kodama, Tetsuro; Saito, Yasuki; Sato, Masami; Tagawa, Yutaka; Baba, Masayuki; Hirano, Takashi; Horai, Takeshi; Matsuno, Yoshihiro

doi:10.1159/000320860

Cited by 8 publications

(8 citation statements)

References 21 publications

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“…There have been only a few reports of cytological analysis in cases of pulmonary PC 14-16. Most of the previous cytological reports have revealed similar findings.…”

Section: Discussionmentioning

confidence: 91%

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Fine-Needle Aspiration Cytology of Pleomorphic Carcinomas of the Lung

et al. 2012

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BackgroundPleomorphic carcinoma (PC) is a rare pulmonary malignancy. Because of its rarity and histological heterogeneity, cytopathologists might suspect PC only rarely on the basis of its cytological specimen. In addition, cytological findings from fine needle aspiration (FNA) specimens have rarely been described. Hence, we investigated the cytological features of FNA in the cases of PC.MethodsWe reviewed 7 FNA specimens of PC. The patients had undergone surgical resection at the Korea Cancer Center Hospital between 2007 and 2011. The cytological features of PC were assessed and compared with the histopathological features of the corresponding surgical specimen. Immunocytochemical analysis with cytokeratin and vimentin was performed on the cell blocks.ResultsThe tumor cells were either dispersed or arranged in loose aggregates, and generally lacked any glandular or squamous differentiation. Pleomorphic or spindle shape tumor cells were observed, and mono-, bi-, or multi-nucleated giant cells were frequently observed. The background showed necrosis and contained numerous lymphocytes and neutrophils. Immunocytochemically, the tumor cells were positive for cytokeratin and vimentin.ConclusionsPC displays characteristic cytological features. It might therefore be possible to make an accurate diagnosis of PC by assessing the degree of nuclear atypia.

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“…There have been only a few reports of cytological analysis in cases of pulmonary PC 14-16. Most of the previous cytological reports have revealed similar findings.…”

Section: Discussionmentioning

confidence: 91%

“…To date, the cytological findings of fine needle aspiration (FNA) of PC have rarely been described with only a few case reports 14-16. The purpose of this study was to investigate the cytomorphological characteristics of PC together with its corresponding histological characteristics, with the aim of improving the preoperative diagnosis of PC.…”

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confidence: 99%

Fine-Needle Aspiration Cytology of Pleomorphic Carcinomas of the Lung

et al. 2012

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“…In cytological preparations, giant cells typically appear as single cells or in flat loose clusters, and occasionally in fascicles. 15 Another specific feature known about this malignancy is the presence of a phenomenon called emperipolesis: collections of polymorphonuclear leukocytes within the giant cells, apparently phagocytosing cytoplasmic contents. 6 However, the etiology of emperipolesis in GCCL is unclear.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Molecular features of giant-cell carcinoma of the lung: a case report and literature review

Li¹,

Zhang²,

Liu³

et al. 2018

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Giant-cell carcinoma of the lung (GCCL) is a rare histological form of poorly differentiated non-small-cell lung cancer, which is classified as a subtype of pulmonary sarcomatoid carcinomas. In this case report, we describe the case of a 50-year-old Chinese male who presented with a pulmonary nodule in the right upper lobe of his lung. After thoracoscopic lobectomy, a histopathologic diagnosis of GCCL was made. He did well postoperatively, showing no local recurrence or distal disease in a 7-year follow-up period. Furthermore, for this case, we also analyzed 295 tumor-related driver genes with high-throughput sequencing technology. We found that treatment using MEK inhibitor, CDK 4/6 inhibitor, and TP53 inhibitor may provide a new therapeutic direction for GCCL. Therefore, complete tumor excision is the best choice of treatment strategy at the early stage of GCCL and gene target therapy may be a new therapeutic option for this disease.

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“…Moreover, Fishback et al reported that only 1 of 48 cases of giant cell carcinoma had SCLC component (13). Only a few reports regarding the cytological features of pleomorphic carcinoma have been published (14)(15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

Combined small cell carcinoma with giant cell carcinoma component of the lung: A case successfully diagnosed by computed tomography‑guided fine‑needle aspiration cytology

et al. 2017

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Abstract. Combined small cell lung carcinoma (SCLC) is a rare variant of SCLC and is defined as a mixture of SCLC and non-SCLC components. Although any histopathological subtype may be present as a non-SCLC component, the presence of pleomorphic carcinoma components are extremely rare. The present report describes the first documented cytological features of combined SCLC with a giant cell carcinoma component. A 50-year-old Japanese female with a history of smoking presented with a mass lesion in the left lung. Computed tomography-guided fine-needle aspiration cytology and needle biopsy were performed, followed by a lobectomy. A Papanicolaou smear revealed the presence of two distinct neoplastic components in a necrotic background. One component was SCLC, which comprised small-sized neoplastic cells containing scant cytoplasm and round to oval nuclei with dispersed granular chromatin without nucleoli. The other component was giant cell carcinoma, which was composed of large-sized neoplastic cells containing irregular large hyperchromatic nuclei (approximately 7 to 10 times larger than those of SCLC). SCLC was demonstrated in the biopsy specimen, however no giant cell carcinoma component was present. Histopathological study of the lobectomy specimen verified a diagnosis of combined SCLC with giant cell carcinoma component. Both SCLC and giant cell carcinoma exhibit characteristic cytological features, therefore, albeit extremely rare, careful observation may lead to a correct diagnosis of combined SCLC in the cytological specimen. IntroductionCombined small cell lung carcinoma (SCLC) is categorized as a histopathological variant of SCLC, and defined as an admixture of SCLC and non-SCLC components (1). The incidence of combined SCLC is 0.2%-1.3% of the surgically resected primary lung cancers (2,3), and comprises up to 28% of the surgically resected SCLC cases (4). Adenocarcinoma and squamous cell carcinoma are the common components of non-SCLC (2-5). In the case series reported by Yamada et al adenocarcinoma is the most common histopathological subtype of the non-SCLC component (6/9 cases), followed by adenocarcinoma and squamous cell carcinoma (2 cases) and squamous cell carcinoma (1 case) (2). Any histopathological subtypes can be present as a non-SCLC component (1). However, the occurrence of a pleomorphic (giant cell) carcinoma component in combined SCLC is extremely rare (6-9). We have already reported on the clinical and histological characteristics of this case (10), and this report we described the detailed cytological features of combined SCLC with giant cell carcinoma component in order to draw attention to a potential cause of diagnostic error. Case reportA 50-year-old Japanese female was referred to Kansai Medical University Hospital because of an abnormal chest shadow, which had been detected by a chest X-ray examination at an out-patient clinic. She was a heavy smoker (30 cigarettes daily over 30 years). Chest computed tomography (CT) demonstrated a relatively well-circumscribed mass lesion, measuri...

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Cytological Characteristics of Pulmonary Pleomorphic and Giant Cell Carcinomas

Cited by 8 publications

References 21 publications

Fine-Needle Aspiration Cytology of Pleomorphic Carcinomas of the Lung

Fine-Needle Aspiration Cytology of Pleomorphic Carcinomas of the Lung

Molecular features of giant-cell carcinoma of the lung: a case report and literature review

Combined small cell carcinoma with giant cell carcinoma component of the lung: A case successfully diagnosed by computed tomography‑guided fine‑needle aspiration cytology

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