1968
DOI: 10.1084/jem.127.3.455
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Cytological Evidence for a Relationship Between Normal Hematopoietic Colony-Forming Cells and Cells of the Lymphoid System

Abstract: PLATES 61 AND 62

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Cited by 401 publications
(119 citation statements)
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“…of Biomedical Sciences and Human Oncology, Clinica Medica I, Via Genova 3, 10126 Torino, Italy; Fax: 39 11 6637 238 Received 17 November 1997; accepted 23 January 1998 are characterized by an ability to generate very large numbers (Ͼ10 13 ) of all known mature blood cell types. [1][2][3][4] In both mouse and human systems, a subset of extremely primitive hematopoietic cells has been identified because of its ability to generate clonogenic cells (colony-forming cells (CFC)) for at least 5 weeks on suitable stroma feeder layers of murine or human origin. 5 These long-term culture-initiating cells (LTCICs) share a number of features with long-term in vivo repopulating cells.…”
Section: Introductionmentioning
confidence: 99%
“…of Biomedical Sciences and Human Oncology, Clinica Medica I, Via Genova 3, 10126 Torino, Italy; Fax: 39 11 6637 238 Received 17 November 1997; accepted 23 January 1998 are characterized by an ability to generate very large numbers (Ͼ10 13 ) of all known mature blood cell types. [1][2][3][4] In both mouse and human systems, a subset of extremely primitive hematopoietic cells has been identified because of its ability to generate clonogenic cells (colony-forming cells (CFC)) for at least 5 weeks on suitable stroma feeder layers of murine or human origin. 5 These long-term culture-initiating cells (LTCICs) share a number of features with long-term in vivo repopulating cells.…”
Section: Introductionmentioning
confidence: 99%
“…Among these functions may be the involvement in the cellular development of the hemopoietic-immunopoietic system, the cells of which most likely originate from a common pluripotential stem cell (12). The involvement of vitamin E in the development and population kinetics of erythroid cells has already been demonstrated (3,6,8).…”
mentioning
confidence: 99%
“…Further experiments are in progress now to find out the optimal level of vitamin E in the immune response. In the light of these data plus the reports in the literature on the role of vitamin E in erythrocyte regulation (3,6,8) and the common stem cell origin of erythrocyte and lymphoid cells (12), the hypothesis of a direct involvement of vitamin E in immunocyte development and AB regulation is not unlikely, and can be tested experimentally using diets from vitamin E-deficient to fortified, and measuring quantitatively AB biosynthesis and immunocyte kinetics. The synergistic effect observed with the combined vitamin E and altitude treatment suggests that the mechanism of vitamin E action is most likely connected with its antioxidant property; vitamin E combined with hypoxia creates more reducing conditions in the electron transport chain for cellular developmental processes (3).…”
mentioning
confidence: 99%
“…(Received for publication 5 March 1974) There is general agreement that the mature cells of the blood of mammals arise from a pluripotent hemopoietic stem cell (1)(2)(3)(4). This cell is defined by ability to form spleen colonies after injection into lethally irradiated mice (5) and is thus called a spleen colony-forming unit or CFU-s. Colonies of myeloid cells can be formed in vitro (6,3) and the cells which give rise to these colonies (CFU-c) differ in many properties from the CFU-s.…”
mentioning
confidence: 99%