Cytologically Malignant Squamous‐Cell Carcinoma Arising in a Verrucous Carcinoma of the Penis

Abstract

A case of verrucous carcinoma with a focus of cytologically malignant squamous-cell carcinoma is presented. This usually occurs following radiation therapy of the verrucous carcinoma, but may rarely occur de novo, as in this case. The potential usefulness of fine-needle aspiration in detecting focal anaplasia in verrucous carcinoma is discussed. This technique may be especially useful if the lesion is to be destroyed cryosurgically.

Verrucous carcinoma arising in pseudoepitheliomatous keratotic and micaceous balanitis, without evidence of human papillomavirus

“…Development of a squamous carcinoma in a pre‐existing verrucous carcinoma has been reported following radiotherapy. 28 …”

“…Development of a squamous carcinoma in a pre-existing verrucous carcinoma has been reported following radiotherapy. 28 Our findings provide supportive evidence that PKMB has malignant potential. Beljaards et al 1 have suggested that an alternative name, micaceous and verrucous malignant balanitis, should replace PKMB.…”

Squamous Cell Carcinoma Variants of the Upper Aerodigestive Tract: A Comprehensive Review With a Focus on Genetic Alterations

“…Verrucous carcinoma exhibits characteristic cell kinetics that are more akin to those of normal mucosa than they are to conventional squamous cell carcinoma. 100, [102][103][104][105] In particular, DNA synthesis (S-phase) is confined to the basal cell layer, along with the more conventionally detected mitotic activity. The lack of S-phase cells above the basal cell layer is quite unlike the findings in conventional squamous cell carcinomas.…”

“…The lack of S-phase cells above the basal cell layer is quite unlike the findings in conventional squamous cell carcinomas. 100,103,104 Verrucous carcinomas may be diploid or aneuploid. 104,106 In the Choi et al 107 analysis of microsatellite markers in head and neck squamous cell carcinomas, verrucous carcinomas showed similar losses when compared with conventional, well-differentiated squamous cell carcinomas.…”

Cytological diagnosis of nonulcerative penile neoplasms: Report of two cases

“…[5][6][7][8][9] FNAC has detected focal anaplasia in verrucous carcinoma. 11 In the only reported series, 11 patients underwent FNAC of the penis. FNAC diagnosed five metastatic lesions, one benign lesion, and three lesions that were primary ulcerative SCC.…”