Cytology of Rosai‐Dorfman disease

Lussier, Christian; Klijanienko, Jerzy; Brisse, H.; Quintana, E.; Vielh, Philippe; Brousse, Nicole

doi:10.1002/dc.1064

Cited by 9 publications

(3 citation statements)

References 9 publications

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“…Since its original description, more than 600 cases of RDD have been reported. It is more common during the first and second decades of life, and it is more prevalent in males and blacks (2–4) .…”

Section: Discussionmentioning

confidence: 99%

Extranodal Rosai-Dorfman disease as a pelvic mass

Leiva¹,

Bofill²,

Sevin

et al. 2006

International Journal of Gynecological Cancer

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Rosai-Dorfman disease (RDD) is a rare histiocytic disorder of unknown cause. RDD most commonly involves the cervical lymph nodes, but extranodal involvement has been described. We report the case of a patient with extranodal RDD that presented as a retroperitoneal mass obstructing the left ureter. The patient underwent surgical resection of the mass, followed by a 5-month course of vinblastine. There was no evidence of progressive disease 22 months after surgery.

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Section: Discussionmentioning

confidence: 99%

Extranodal Rosai-Dorfman disease as a pelvic mass

Leiva¹,

Bofill²,

Sevin

et al. 2006

International Journal of Gynecological Cancer

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“…All cytology material including air‐dried Diff‐Quik and alcohol‐fixed Papanicolaou smears, and formalin (n = 3) or Cytolyt‐fixed (n = 2) cell blocks were reviewed for the presence or absence of cytologic characteristics of RDD that were previously described 3‐7 . Hematoxylin and eosin‐stained concurrent core biopsies and surgical resections (where applicable), as well as immunocytochemical and special stains, were also reviewed.…”

Section: Methodsmentioning

confidence: 99%

“…These histiocytes have abundant, granular and eosinophilic cytoplasm with variably enlarged nuclei and prominent nucleoli. The key cytomorphologic feature is “emperipolesis”, the engulfment of lymphocytes, plasma cells, and occasionally, erythrocytes by histocytes 3‐6 . Immunohistochemically the histiocytic cells express histiocytic markers CD68 and CD163, as well as S100 which distinguishes them from other entities with proliferating histiocytes 7 .…”

Section: Introductionmentioning

confidence: 99%

Rosai‐Dorfman disease of the pancreas: Cytologic analysis of three cases presenting as pancreatic masses

Roe

Tracht²,

Madrigal

et al. 2020

Diagnostic Cytopathology

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Rosai‐Dorfman Disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a rare entity characterized by proliferating S100‐positive histiocytes. It is most commonly found in lymph nodes with extranodal involvement usually occurring in the head and neck. Pancreatic involvement is extremely rare. The pathology department archives were searched for fine needle aspirations and pancreatic resections showing evidence of RDD. Clinicopathologic features, cytologic smears, cell blocks, immunocytochemical stains and surgical resections were reviewed. Three cases were identified. They were all females, aged 65, 69 and 75, with involvement of the pancreatic tail or head by solid masses of median size 2.3 cm (range 2.1‐4.5 cm). Cytologic findings on smears included multiple histiocyte clusters resembling loosely cohesive epithelioid granulomas, singly dispersed histiocytes with moderate to marked nuclear atypia and characteristic emperipolesis. These atypical histiocytes stained positively for CD68, CD163 and S100. Smear background contained variable mixed inflammatory cells, necrotic debris and stromal fragments. The RDD diagnosis was further confirmed on pancreatic resection in two patients and core biopsy in one. The latter patient required three separate procedures before a definitive diagnosis was made. RDD of pancreas is a rare benign inflammatory condition that is diagnostically challenging on cytology. This can cause delays in cytologic diagnosis and/or misdiagnosis. Identification of characteristic cytologic features, primarily histiocytes with emperipolesis, and matching immunocytochemical profile can ensure accurate diagnosis and distinction from mimics.

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Histiocytosis and Storage Diseases

Hammar

Allen

2008

Dail and Hammar’s Pulmonary Pathology

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Cytology of Rosai‐Dorfman disease

Cited by 9 publications

References 9 publications

Extranodal Rosai-Dorfman disease as a pelvic mass

Extranodal Rosai-Dorfman disease as a pelvic mass

Rosai‐Dorfman disease of the pancreas: Cytologic analysis of three cases presenting as pancreatic masses

Histiocytosis and Storage Diseases

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