Histiocytosis and Storage Diseases

Hammar, Samuel P.; Allen, Timothy Craig

doi:10.1007/978-0-387-68792-6_16

Cited by 4 publications

(5 citation statements)

References 180 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LSD is a rare and fatal variant of histiocytosis [1,9]. It can easily be missed for other conditions causing anemia, thrombocytopenia, and hepatosplenomegaly.…”

Section: Discussionmentioning

confidence: 99%

“…It affects many systems in the body characterized by monoclonal migration and proliferation of specific dendritic cells. It affects the bones and skin primarily, but also involves other organs as well or appears as a multi-system disease leading to different clinical manifestations [1,9,13]. LCH includes three main classes, including dendritic cell disorders, disorders of macrophages, and histocytes malignant disorders [2].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Letterer Siwe Disease (LSD): A Case Report

Suad¹,

Elamin²,

Elseed³

2018

SJMS

View full text Add to dashboard Cite

Background: Letterer Siwe Disease (LSD) is one of variants of langerhans cell histiocytosis (LCH) which is considered as a rare disease that affects many systems in the body, it is characterized by monoclonal migration and proliferation of specific dendritic cells. The disease affects the bones and skin primarily, but can involve other organs as well or appear as a multi-system disease leading to different clinical manifestations and eventually death.

show abstract

“…LSD is a rare and fatal variant of histiocytosis [1,9]. It can easily be missed for other conditions causing anemia, thrombocytopenia, and hepatosplenomegaly.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Letterer Siwe Disease (LSD): A Case Report

Suad¹,

Elamin²,

Elseed³

2018

SJMS

View full text Add to dashboard Cite

show abstract

“…Smokers constitute the majority of cases of the otherwise rare pulmonary Langerhans’ cell hystiocytosis interstitial lung disease. The lysosomes of smoker’s macrophages that are associated with Langerhans’ hystiocytosis cells (dendritic cells) are described as containing numerous needle-like inclusions of aluminum silicate (35). Therefore, it is possible that multiple components of cigarette smoke, including cadmium and silica (carcinogens), and aluminum silicates or other silicates may be agents involved in tumorigenesis (25) and in the progression of chronic inflammation from which fibrotic, obstructive, and interstitial pulmonary disease result (25,27,30–35) as a consequence of cigarette smoking.…”

Section: Discussionmentioning

confidence: 99%

Electron Microscopic Analysis of Silicate and Calcium Particles in Cigarette Smoke Tar

Pappas

Halstead

Watson

2016

Int J Respir Pulm Med

View full text Add to dashboard Cite

Scanning electron microscopy with energy dispersive x-ray spectroscopy (SEM-EDS) supplies information that is complementary to those data traditionally obtained using inductively coupled plasma-mass spectrometry for analysis of inorganic tobacco and tobacco smoke constituents. The SEM-EDS approach was used to identify select inorganic constituents of mainstream cigarette smoke "tar." The nature of SEM-EDS instrumentation makes it an ideal choice for microstructural analyses as it provides information relevant to inorganic constituents that could result from exposure to combusted tobacco products. Our analyses show that aluminum silicates, silica, and calcium compounds were common constituents of cigarette mainstream smoke "tar."Identifying inorganic tobacco smoke constituents is important because inhalation of fine inorganic particles could lead to inflammatory responses in the lung and systemic inflammatory responses. As cigarette smoking causes chronic inflammation in the respiratory tract, information on inorganic particulate in mainstream smoke informs efforts to determine causative agents associated with increased morbidity and mortality from tobacco use.

show abstract

“…ственно в легком или легочных макрофагов, трансдиффе-ренцирующихся в дендритические клетки [4]. «Эпителиальный» тип дендритических клеток харак-теризуется экспрессией CD1a, E-кадхерина, лангерина и S-100 [4].…”

Section: Abstract: Pulmonary Langerhans Cell Histiocytosis Diagnosiunclassified

“…«Эпителиальный» тип дендритических клеток харак-теризуется экспрессией CD1a, E-кадхерина, лангерина и S-100 [4].…”

Section: Abstract: Pulmonary Langerhans Cell Histiocytosis Diagnosiunclassified

Pathomorphological features of pulmonary Langerhans cell histiocytosis

Черняев¹,

Войтковская²,

Тарабрин³

et al. 2014

Arkh. patol.

View full text Add to dashboard Cite

Лангергансоклеточный гистиоцитоз легких (ЛКГЛ) (ранее используемые названия: легочная эозинофильная гранулема, легочный лангергансоклеточный гранулема-тоз, легочный гистиоцитоз Х) является редким заболева-нием легких, его распространенность оценивают как 1:560 000 или 3-5% всех интерстициальных заболеваний легких. ЛКГЛ выявляют, как правило, в возрасте 20-40 лет у па-циентов-курильщиков (обычно стаж курения свыше 10 пачек/лет) [1]. Курение считается единственным этио-логически доказанным фактором заболевания. ЛКГЛ морфологически характеризуется формированием грану-лем лапчатого вида, в состав которых входят клетки Лан-герганса, пигментированные макрофаги, эозинофилы, лимфоциты, плазматические клетки.Клетки Лангерганса впервые описаны P. Langerhans [2], впоследствии Birbeck при электронно-микроскопиче-ском исследовании обнаружил, что клетки Лангерганса содержат в цитоплазме характерные гранулы, или Х-тельца [3].Предполагают, что дендритические клетки могут по-являться в легких из циркулирующих дендритических клеток под действием хемокинов, в результате дифферен-цировки предшественников под действием местных цито-кинов, а также, возможно, в результате пролиферации предполагаемых клеток-предшественников непосред- Приведена клинико-рентгенологическая характеристика лангергансоклеточного гистиоцитоза легких (ЛКГЛ). Описаны патогистологические изменения в легких, охарактеризован клеточный состав гранулемы, приведены методы, позволяю-щие подтвердить диагноз ЛКГЛ. Приведено наблюдение ЛКГЛ с тяжелой дыхательной недостаточностью, по поводу кото-рой проведена двусторонняя трансплантация легких с гистологическим исследованием удаленных легких.Ключевые слова: лангергансоклеточный гистиоцитоз легких, диагностика, патологическая анатомия.The paper provides the clinical and X-ray characteristics of pulmonary Langerhans cell histiocytosis (PLCH). It describes pulmonary pathohistological changes in this disease, characterizes the cellular composition of granuloma, and gives methods that can verify the diagnosis of PLCH. A case of PLCH with severe respiratory failure, for which bilateral lung transplantation and histological examination of removed lungs have been made, is described.

show abstract

Histiocytosis and Storage Diseases

Cited by 4 publications

References 180 publications

Letterer Siwe Disease (LSD): A Case Report

Letterer Siwe Disease (LSD): A Case Report

Electron Microscopic Analysis of Silicate and Calcium Particles in Cigarette Smoke Tar

Pathomorphological features of pulmonary Langerhans cell histiocytosis

Contact Info

Product

Resources

About