Cytomegalovirus and Human Herpesvirus 6 Both Cause Viral Disease After Renal Transplantation

Ratnamohan, V. Mala; Chapman, Jeremy; Howse, Helen; Bovington, Karen J.; Robertson, Paul; Byth, Karen; Allen, Richard D.; Cunningham, Anthony L.

doi:10.1097/00007890-199810150-00011

Cited by 89 publications

(61 citation statements)

References 37 publications

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“…Unfortunately the study was not designed to document the pertinence of our prescription since both prophylactic and preemptive therapy may led to the emergence of late CMV disease in transplant recipients after cessation of therapy [ll]. The role of CMV disease in the development of chronic rejection [21] was not investigated, nor was the role of human herpesvirus 6 which may induce viral disease in association with CMV [20].…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus-related disease and risk of acute rejection in renal transplant recipients: a cohort study with case-control analyses

Toupance

Bouedjoro-Camus

Carquin³

et al. 2000

Transplant Int

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Section: Discussionmentioning

confidence: 99%

Cytomegalovirus-related disease and risk of acute rejection in renal transplant recipients: a cohort study with case-control analyses

Toupance

Bouedjoro-Camus

Carquin³

et al. 2000

Transplant Int

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“…47,48 CMV infection is increasingly prevalent with age; thus, most of the adult population has been infected. Moreover, this infection is usually subclinical or latent.…”

Section: Infectionsmentioning

confidence: 99%

Hepatic artery thrombosis after orthotopic liver transplantation: A review of nonsurgical causes

et al. 2001

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“…8,19,20 EBV-associated PTLD appears to be most effectively treated by tapering of the doses of the immunosuppressive drugs used to prevent transplant organ rejection. 17,21 Because different viruses can give rise to similar organ pathologies, [22][23][24][25][26][27][28][29] selection of the appropriate therapeutic approach involves accurate diagnosis of disease etiology.…”

mentioning

confidence: 99%

Predictive Value of Quantitative PCR-Based Viral Burden Analysis for Eight Human Herpesviruses in Pediatric Solid Organ Transplant Patients

Bai

Rogers

Harkins

et al. 2000

The Journal of Molecular Diagnostics

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Human herpesviruses can cause significant morbidity and mortality in pediatric solid organ transplant recipients. It was hypothesized that viral burden quantification by polymerase chain reaction using an internal calibration standard could aid in distinguishing between viral disease and latency. Here we report the results of a 2-year prospective study of 27 pediatric solid organ (liver, kidney, or heart) transplant recipients in which multiple samples were analyzed for levels of all eight human herpesviruses by internal calibration standard-polymerase chain reaction. Herpes simplex viruses 1 and 2, varicella-zoster virus, and Kaposi's sarcoma-associated herpesvirus were not detected in any of these samples. Human herpesvirus types 6 and 7 were detected in half of the patients, but were present at low levels, similar to those found in reference populations. Epstein-Barr virus (EBV) and cytomegalovirus (CMV) were detected in 89% and 56% of the patients, respectively. Viral burden analysis suggested distinct patient populations for CMV, with a natural cutoff of 10,000 viral targets/ml blood strongly associated with disease. In some cases, a dramatic increase in CMV levels preceded clinical evidence of disease by several weeks. EBV viral burden was relatively high in the only patient presenting with an EBV syndrome. However, two other patients without evidence of EBV disease had single samples with high EBV burden. Rapid reduction in both EBV and CMV burden occurred with antiviral treatment. These data suggest that viral burden analysis using internal calibration standard-polymerase chain reaction for CMV, and possibly other herpesviruses, is an effective method for monitoring pediatric transplant patients for significant herpesvirus infection and response to therapy.

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Cytomegalovirus and Human Herpesvirus 6 Both Cause Viral Disease After Renal Transplantation

Cited by 89 publications

References 37 publications

Cytomegalovirus-related disease and risk of acute rejection in renal transplant recipients: a cohort study with case-control analyses

Cytomegalovirus-related disease and risk of acute rejection in renal transplant recipients: a cohort study with case-control analyses

Hepatic artery thrombosis after orthotopic liver transplantation: A review of nonsurgical causes

Predictive Value of Quantitative PCR-Based Viral Burden Analysis for Eight Human Herpesviruses in Pediatric Solid Organ Transplant Patients

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