Cytomegalovirus enteritis after autologous peripheral blood stem cell transplantation

Abstract

A 61-year-old male with non-Hodgkin's lymphoma (peripheral T-cell lymphoma, unspecified, clinical stage IVb) received autologous peripheral blood stem cell transplantation (PBSCT) during first remission. He was seropositive for cytomegalovirus (CMV) prior to autologous PBSCT. His posttransplant clinical course was complicated by refractory CMV enteritis, which manifested persistent abdominal pain, diarrhea, and bloody stool. Generally, gastrointestinal CMV disease is relatively rare after autologous PBSCT. However, our case indicates that CMV infection must be considered as a differential diagnosis in cases of unexplained hemorrhagic enteritis following autologous PBSCT.

Significance of Colonoscopy in Patients with Intestinal Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation

“…Distinguishing intestinal GVHD from such in− fections is important in terms of therapeutic strategy. Despite the fact that a bloody stool tends to be a symptom of cytomega− lovirus colitis [8] and profuse watery diarrhea a more prominent symptom (rather than a bloody stool) of intestinal GVHD [6,9], it is still difficult to differentiate the two disorders. Furthermore, it is not always easy to differentiate between intestinal GVHD and drug−induced colitis after hematopoietic stem cell transplanta− tion, though to some extent this is confirmed by the clinical course (on stopping the drugs, for example) and by finding histo− logical evidence of GVHD in other organs.…”

Rectal amputation sparing by haemostatic therapy with recombinant factor VIIa in a patient with cytomegalovirus–related colitis

“…Codeluppi 3 ,Erica Villa 4 ,Alberto Pasetto 1 1 Cattedra eDivisione di Anestesiologia eRianimazione, 2 Cattedra e Divisione di Ematologia, 3 Cattedra eDivisione di Malattie Infettive, 4 Cattedra eDivisione di Gastroenterologia; Università degliStudidi Modena eReggio Emilia ePoliclinico di Modena, Modena, Italy…”