An abnormal accumulation of fluorine-18-FDG PET in cytomegalovirus enteritis—A case report

Nishizaki, Takashi; Ito, Kengo; Kato, Takashi; Kato, Rikio; Okuda, Makiko; Arima, Toshio; Bundo, Masahiko; Kawatsu, Shoji; Hayasaka, Kazumasa; Ishigaki, Takeo

doi:10.1007/bf02985595

Cited by 11 publications

(6 citation statements)

References 18 publications

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“…CMV infections can show increased FDG uptake in PET scans. For example, lymphadenitis [ 20 ], GI infections [ 27 , 28 ], and infectious mononucleosis [ 29 ]. A case of CMV lymphadenitis mimicking lymphoma relapse in PET scan has been reported [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

A Clinicopathological Study of Cytomegalovirus Lymphadenitis and Tonsillitis and Their Association with Epstein–Barr Virus

Huang

et al. 2021

Infect Dis Ther

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Introduction: Histopathological characteristics of cytomegalovirus (CMV) lymphadenitis have been well described. Rare studies have reported the immune status and clinical features. Clinically, experts believed that CMV lymphadenitis develops in immunocompromised and immunocompetent patients. Infectious mononucleosis (IM)-like syndrome is the most well-known clinical presentation. Methods: We reviewed archived CMV immunohistochemical stains on lymphoid tissues. The clinicopathological features of CMVpositive cases were studied. Results: For lymph nodes, we detected CMV in 29% (5/17) allogeneic peripheral blood hematopoietic stem cell transplantation

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Section: Discussionmentioning

confidence: 99%

A Clinicopathological Study of Cytomegalovirus Lymphadenitis and Tonsillitis and Their Association with Epstein–Barr Virus

Huang

et al. 2021

Infect Dis Ther

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“…The changes revealed by the PET/CT were consistent with an acute infectious colitis. Only one case of 18 F-FDG uptake in acute CMV colitis has been previously reported [8]. This case highlights that a positive 18 F-FDG PET/CT scan of the colon can be due to CMV colitis.…”

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confidence: 71%

18F-FDG PET/CT Findings in Cytomegalovirus Colitis

et al. 2018

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We present a case demonstrating the diagnostic work-up of a patient undergoing azathioprine treatment for inflammatory bowel disease (IBD), diagnosed with an acute cytomegalovirus (CMV) infection and CMV colitis. An 18F-FDG positron emission tomography/computed tomography (PET/CT) performed 2 weeks after debut of symptoms revealed pathological 18F-FDG uptake in the left side of the colon mucosa, mimicked activity of IBD. However, a diagnosis of CMV colitis was based on the presence of CMV IgM antibodies, a seroconversion of CMV IgG antibodies, presence of CMV DNA in plasma and the finding af CMV DNA in biopsies from the intestinal mucosa. The patient responded to treatment with ganciclovir. This case highlights that a positive 18F-FDG PET/CT scan of the colon can be due to CMV colitis.

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“…It has been reported that abnormal FDG accumulation is occasionally observed in infection by CMV or Epstein-Barr virus [5][6][7]. Also, clonal T-cell expansion is also observed in CMV infection [8,9].…”

Section: Discussionmentioning

confidence: 99%

Severe Cytomegalovirus Colitis with Highly Elevated sIL-2R Mimicking Aggressive Transformation of Adult T-Cell Lymphoma

Tabata¹,

Tabata

Yasumizu

2015

Antiviral Therapy

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A smouldering adult T-cell leukaemia/lymphoma (ATLL) patient was admitted because of multiple erosions in the colon, which were infiltrated by a mixed population of lymphocytes. PET/CT demonstrated diffuse F-Fluorodeoxyglucose accumulation in the whole colon accompanied by multiple lymph node swelling. Histological examinations of lymph node suggested aggressive transformation to lymphoma type of ATLL. However, the general condition worsened with extremely elevated LDH, cytomegalovirus pp65 and sIL-2R after the administration of prednisolone. By contrast, subsequent administration of ganciclovir with tapered prednisolone ameliorated the laboratory findings. Differential diagnosis for aggressive ATLL and serious cytomegalovirus infection is needed.

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An abnormal accumulation of fluorine-18-FDG PET in cytomegalovirus enteritis—A case report

Cited by 11 publications

References 18 publications

A Clinicopathological Study of Cytomegalovirus Lymphadenitis and Tonsillitis and Their Association with Epstein–Barr Virus

A Clinicopathological Study of Cytomegalovirus Lymphadenitis and Tonsillitis and Their Association with Epstein–Barr Virus

18F-FDG PET/CT Findings in Cytomegalovirus Colitis

Severe Cytomegalovirus Colitis with Highly Elevated sIL-2R Mimicking Aggressive Transformation of Adult T-Cell Lymphoma

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