Cytomegalovirus infection in kidney allografts: a review of literature

Morgantetti, Giuliano Ferreira; Balancin, Marcelo Luiz; Medeiros, Guilherme Alencar de; Dantas, Márcio; Silva, Gyl Eanes Barros

doi:10.21037/tau.2018.10.14

Cited by 20 publications

(31 citation statements)

References 23 publications

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“…Cytomegalovirus (CMV) infection is the most important serious viral infection that complicates solid organ transplantation [1]. CMV infection can result in CMV disease, which, in severe cases, may lead to hospitalization, morbidity and death [2]. In addition, CMV infection has been associated with secondary effects on the immune system, predisposing patients to opportunistic infections [3,4], diabetes mellitus, cardiovascular disease and graft loss [5,6].…”

Section: Introductionmentioning

confidence: 99%

No association of genetic variants in TLR4, TNF-α, IL10, IFN-γ, and IL37 in cytomegalovirus-positive renal allograft recipients with active CMV infection—Subanalysis of the prospective randomised VIPP study

et al. 2021

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Background Cytomegalovirus (CMV) infection is amongst the most important factors complicating solid organ transplantation. In a large prospective randomized clinical trial, valganciclovir prophylaxis reduced the occurrence of CMV infection and disease compared with preemptive therapy in CMV-positive renal allograft recipients (VIPP study; NCT00372229). Here, we present a subanalysis of the VIPP study, investigating single nucleotide polymorphisms (SNPs) in immune-response-related genes and their association with active CMV infection, CMV disease, graft loss or death, rejection, infections, and leukopenia. Methods Based on literature research ten SNPs were analyzed for TLR4, three for IFN-γ, six for IL10, nine for IL37, and two for TNF-α. An asymptotic independence test (Cochran-Armitage trend test) was used to examine associations between SNPs and the occurrence of CMV infection or other negative outcomes. Statistical significance was defined as p<0.05 and Bonferroni correction for multiple testing was performed. Results SNPs were analyzed on 116 blood samples. No associations were found between the analyzed SNPs and the occurrence of CMV infection, rejection and leukopenia in all patients. For IL37 rs2723186, an association with CMV disease (p = 0.0499), for IL10 rs1800872, with graft loss or death (p = 0.0207) and for IL10 rs3024496, with infections (p = 0.0258) was observed in all patients, however did not hold true after correction for multiple testing. Conclusion The study did not reveal significant associations between the analyzed SNPs and the occurrence of negative outcomes in CMV-positive renal transplant recipients after correction for multiple testing. The results of this association analysis may be of use in guiding future research efforts.

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Section: Introductionmentioning

confidence: 99%

No association of genetic variants in TLR4, TNF-α, IL10, IFN-γ, and IL37 in cytomegalovirus-positive renal allograft recipients with active CMV infection—Subanalysis of the prospective randomised VIPP study

et al. 2021

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“…As a result, despite antiviral preventive strategies, HCMV infection is an important complication in individuals receiving solid organ transplants, including kidney recipients (Carney, 2013 ). Kidney transplant is the most common organ transplant surgeries performed nowadays and HCMV infection is a regular complication, which usually appears during the first year after renal transplantation, notably when a seronegative allograft recipient receives a kidney from a HCMV seropositive donor (Morgantetti et al, 2019 ). The effect of HCMV on the destiny of solid organ transplantation is significant, not only causing grave and potentially lethal illness, but also promoting allograft rejection, additional opportunistic infections, post-transplant lymphoproliferative disorders, vascular disease, and the entire patient and allograft survival (Razonable and Humar, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Human Cytomegalovirus Inhibits Autophagy of Renal Tubular Epithelial Cells and Promotes Cellular Enlargement

Giuliani

Hernández

Tohmé

et al. 2020

Front. Cell. Infect. Microbiol.

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Human Cytomegalovirus (HCMV) is a frequent opportunistic pathogen in immunosuppressed patients, which can be involved in kidney allograft dysfunction and rejection. In order to study the pathophysiology of HCMV renal diseases, we concentrated on the impact of HCMV infection on human renal tubular epithelial HK-2 cells. Our aim was to develop a model of infection of HK-2 cells by using the viral strain TB40/E, that contains the extended cell tropism of clinical isolates and the efficient viral multiplication in cell culture of laboratory-adapted strains. We observed that HK-2 cells can be infected by HCMV and expressed viral antigens, but they do not produce extracellular viral particles. We then studied the interplay of HCMV with ciliogenesis and autophagy. Primary cilium (PC) is a stress sensor important to maintain renal tissue homeostasis that projects from the apical side into the lumen of tubule cells. PC formation and length were not modified by HCMV infection. Autophagy, another stress response process critically required for normal kidney functions, was inhibited by HCMV in HK-2 cells with a reduction in the autophagic flux. HCMV classically induces an enlargement of infected cells in vivo and in vitro, and we observed that HCMV infection led to an enlargement of the HK-2 cell volume. Our results constitute therefore an excellent starting point to further explore the role of these mechanisms in renal cells dysfunction.

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“…However, there has been a well-established program that has been running regularly since the beginning of 2005 in the Urology and Nephrology Center at Al-Thawra Modern General Hospital, Sana'a 7 . Despite significant advances in the field of kidney transplantation, long-term graft survival has not increased significantly due to the continuing effect of immunosuppressive and infectious disease on transplant recipients 8,9 . Several immunosuppressive agents are currently in use in protective immunity in kidney transplant recipients.…”

Section: Introductionmentioning

confidence: 99%

Side Effects of Cyclosporine Compared to Tacrolimus Among Yemeni Kidney Transplant Patients Who Share the Same Adjuvant Agents: Mycophenolate Mofetil and Prednisone

et al. 2020

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Background: A renal allograft is the optimum therapeutic option for patients with end stage renal diseases. Nevertheless, rejection still represents a large challenge. So as to overcome this matter, treatment strategies comprise the combined use of anti-inflammatory and immunosuppressive agents, although they are not free from complications . Interestingly, the major cause of morbidity and mortality after the first transplanted year are due to disorders unrelated directly to immunologic etiology or disease related to immunosuppressive drugs. Objectives: The purpose of this study is to determine the side effects in renal transplant Yemeni patients adherence to cyclosporine compared to tacrolimus sharing the same adjuvant agents which are mycophenolate mofetil "MMF" and prednisone. Subject and methods: This prospective study was carried on 100 kidney transplanted Yemeni patients divided into two groups: cyclosporine group (n=50) and tacrolimus group (n=50), each member of these groups was visited three times, blood samples were collected for biochemical functions including fasting blood sugar, liver enzymes, kidney functions, lipid profiles and white blood cells counts and results were obtained from the tests performed. Body weight and blood pressure had been examined; clinical complications were also recorded. Results: This study showed that serum total and direct bilirubine, gamma glutamyl transferase "GGT" and lipid profiles were elevated in cyclosporine group, whereas in tacrolimus group they were within normal range. The incidence of complicated events reported as follows: Hairtusim, gum hyperplasia, herpeszoster, CUSHING face and obesity were obviously present in cyclosporine group, while in tacrolimus group diabetes mellitus, hair loss and gastrointestinal tract infections were in existence. Conclusion: This study found that a tacrolimus-based treatment was significantly better than an immunosuppressive regimen based on cyclosporine due to the generally less side effects associated with tacrolimus, despite its effect on increasing diabetes among kidney transplant patients. Peer Review History: Received: 18 September 2020; Revised: 5 October; Accepted: 16 October, Available online: 15 November 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com Dr. Mohamed Awad AbdAlaziz Mousnad, International University of Africa (IUA) and Sudan, m_abdalaziz@yahoo.com Maged Almezgagi, The Key Laboratory of high-altitude medical application of Qinghai Province, Qinghai Xining 810001, China. 1902244017@qq.com Ali Awad Allah Ali Moh. Saeed, National University, Sudan, alimhsd@gmail.com Comments of reviewer(s): Similar Articles: LEVEL OF LEAD IN THE BLOOD AMONG FUEL STATION EMPLOYEES AND ITS RELATIONSHIP TO IMPAIRED LIVER AND KIDNEY FUNCTIONS IN DAMASCUS; SYRIA: OCCUPATIONAL EXPOSURE TO LEAD BACTERIAL CONTAMINATION OF DIALYSIS WATER AND DIALYSATE AT MUKALLA ARTIFICIAL KIDNEY CENTER IN MUKALLA CITY - HADHRAMAUT - YEMEN: RATE OF CONTAMINATION AND SENSITIVITY OF BACTERIAL ISOLATES TO ANTIBIOTICS

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Cytomegalovirus infection in kidney allografts: a review of literature

Cited by 20 publications

References 23 publications

No association of genetic variants in TLR4, TNF-α, IL10, IFN-γ, and IL37 in cytomegalovirus-positive renal allograft recipients with active CMV infection—Subanalysis of the prospective randomised VIPP study

No association of genetic variants in TLR4, TNF-α, IL10, IFN-γ, and IL37 in cytomegalovirus-positive renal allograft recipients with active CMV infection—Subanalysis of the prospective randomised VIPP study

Human Cytomegalovirus Inhibits Autophagy of Renal Tubular Epithelial Cells and Promotes Cellular Enlargement

Side Effects of Cyclosporine Compared to Tacrolimus Among Yemeni Kidney Transplant Patients Who Share the Same Adjuvant Agents: Mycophenolate Mofetil and Prednisone

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