Cytomegalovirus infection in the Netherlands: Seroprevalence, risk factors, and implications

Korndewal, Marjolein J.; Mollema, Liesbeth; Tcherniaeva, Irina; Klis, Fiona van der; Kroes, Aloys C.M.; Oudesluys‐Murphy, Anne Marie; Vossen, Ann C.T.M.; Melker, Hester E. de

doi:10.1016/j.jcv.2014.11.033

Cited by 98 publications

(117 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The only exception to this trend was observed in children less than 6 months who had high prevalence (84.4%) reflecting transient presence of transplacentally derived maternal IgG antibodies. Similar results were found in majority other studies [10,15,18,19,33]. Comparing seroprevalence in the similar age groups, some differences were found in children and adolescents.…”

Section: Discussionsupporting

confidence: 91%

“…Several European studies have reported a higher CMV seroprevalence in females, although in most instances these differences were small [19,30,31]. Results of this study revealed similar results (76.3% in females vs. 72.0% in males).…”

Section: Discussionsupporting

confidence: 83%

“…In the general population, seroprevalence in Croatia is comparable to that of Portugal (77%) [14]. Lower prevalence rates were reported in the Netherlands (45.6%) [19], France (49.5%) 7 [18], Germany (57.25%) [17] and Spain (62.8%) [30], while Hungary, Turkey and Russia showed higher seroprevalence rates (86% and 80.9-94.8%, respectively) [10,13,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Prevalence rates are reported to be 41%-92% in children and adolescents [12][13][14][15], 45%-94% in adult general population [14,[16][17][18][19], 30%-91.5% in pregnant women [20][21][22][23][24] and 68%-99% in hemodialysis patients [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Seroepidemiology of cytomegalovirus infections in Croatia

Vilibić-Čavlek

Kolarić

Beader

et al. 2016

Wien Klin Wochenschr

View full text Add to dashboard Cite

Objectives: Cytomegalovirus (CMV) is endemic worldwide, with marked differences in the seroprevalence rates between countries. The aim of this study was to analyze the seroprevalence of CMV infection in Croatia. Methods:During a three year period (2013)(2014)(2015), 2438 consecutive serum samples collected from Croatian residents were tested for the presence of CMV IgM and IgG antibodies using enzyme-linked immunoassay. IgM/IgG positive samples were further tested for IgG avidity. Results:The overall seroprevalence rates for CMV IgG and IgM antibodies were 74.4% and 4.3%, respectively. The IgG seroprevalence differed significantly between population groups: children/adolescents 54.6%, adult general population 77.2%, hemodialysis patients 91.4% (p<0.001). CMV seropositivity was strongly age-dependent with prevalence ranging from 53.0% in children less than 10 years to 93.8% in persons above 60 years (p<0.001). There was no difference in the prevalence between women with normal pregnancy and women with bad obstetric history. Gender and place of residence was not associated with CMV seropositivity.Using IgG avidity, current/recent primary CMV infection was confirmed by low/borderline avidity index (AI) in 46.7% participants, while in 53.3% high AI indicated CMV reactivation or reinfection. Primary infections were detected mainly in children and adolescents (83.2% and 70.5%), while reactivations/reinfections were common in persons older than 40 (77.0-100%). Reactivations/reinfections were most commonly detected in hemodialysis patients (92.3%). Logistic regression showed that older age and being on hemodialysis were significant predictors of CMV seropositivity.Conclusions: CMV is widespread in the Croatian population. Older age and being on hemodialysis appeared to be main risk factors for CMV infection.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Seroepidemiology of cytomegalovirus infections in Croatia

Vilibić-Čavlek

Kolarić

Beader

et al. 2016

Wien Klin Wochenschr

View full text Add to dashboard Cite

show abstract

“…(1) In immunocompetent individuals, the infection is usually asymptomatic, mild or causes a mononucleosis syndrome but in immunosuppressed patients it behaves as an opportunistic pathogen, causing severe damage. (2) Specifically in HIV-infected patients with severe immune suppression, it manifests in up to 40% of them throughout their life, usually as ophthalmic manifestations or digestive. (3) However, following the introduction of combination antiretroviral therapy (cART), prognosis has improved, and consequently active infection with cytomegalovirus (AICMV) has decreased.…”

Section: Introductionmentioning

confidence: 99%

Acute respiratory infection: first clinical manifestation of active infection with cytomegalovirus in HIV patients presenting to the emergency department

Perelló

Vergara²,

Camón³

et al. 2016

View full text Add to dashboard Cite

Viral glycoproteomes: technologies for characterization and outlook for vaccine design

et al. 2018

View full text Add to dashboard Cite

It has long been known that surface proteins of most enveloped viruses are covered with glycans. It has furthermore been demonstrated that glycosylation is essential for propagation and immune evasion for many viruses. The recent development of high-resolution mass spectrometry techniques has enabled identification not only of the precise structures but also the positions of such post-translational modifications on viruses, revealing substantial differences in extent of glycosylation and glycan maturation for different classes of viruses. In-depth characterization of glycosylation and other post-translational modifications of viral envelope glycoproteins is essential for rational design of vaccines and antivirals. In this Review, we provide an overview of techniques used to address viral glycosylation and summarize information on glycosylation of enveloped viruses representing ongoing public health challenges. Furthermore, we discuss how knowledge on glycosylation can be translated to means to prevent and combat viral infections.

show abstract

Cytomegalovirus infection in the Netherlands: Seroprevalence, risk factors, and implications

Cited by 98 publications

References 26 publications

Seroepidemiology of cytomegalovirus infections in Croatia

Seroepidemiology of cytomegalovirus infections in Croatia

Acute respiratory infection: first clinical manifestation of active infection with cytomegalovirus in HIV patients presenting to the emergency department

Viral glycoproteomes: technologies for characterization and outlook for vaccine design

Contact Info

Product

Resources

About