Cytomorphology of adult granulosa cell tumor in ascitic fluid

Azad, Kalpana; Khunger, Jitender Mohan

doi:10.4103/0377-4929.59200

Cited by 11 publications

(11 citation statements)

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“…Few reports seem to have focused on cytologic features of pleural and ascitic fluids in AGCT. From the literature, hypercellularity was observed in 93% (13/14) of cases, clusters of neoplastic cells in 100% (15/15), single cells/naked nuclei in 86% (12/14), small nucleoli in 90% (9/10), and nuclear grooves in 73% (11/15), which is similar to the specimens obtained by FNA or imprint.…”

Section: Discussionsupporting

confidence: 60%

“…Differential diagnoses for cytologic specimens include carcinoid, small cell carcinoma, undifferentiated carcinoma, Brenner tumor, sex cord tumor with annular tubules (SCTAT), and papillary carcinoma of the thyroid . Carcinoid displays ungrooved nuclei with “salt and pepper” chromatin, indistinct nucleoli, and eosinophilic granular cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…Cytologic examination of pleural and ascitic fluids allows more accurate staging at initial assessment, but few reports have described cytologic findings of AGCT in pleural and ascitic fluids . Therefore, we report the cytologic features of AGCT presenting with exfoliated tumor cells in pleural effusion and ascites.…”

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confidence: 93%

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Cytologic features of ovarian granulosa cell tumors in pleural and ascitic fluids

Omori

Kondo

Yuminamochi

et al. 2015

Diagnostic Cytopathology

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Adult granulosa cell tumor (AGCT) is an uncommon neoplasm of the ovary with potential for aggressive behavior and late recurrence. The most important prognostic factor for AGCT is tumor stage. Thus, cytological assessment of pleural or ascitic fluids is crucial for initial staging and subsequent patient management. We report herein two cases of ovarian AGCT presenting with exfoliated tumor cells in pleural and ascitic fluid. The first case involved a 61-year-old woman who presented with stage Ic (a) AGCT. Seven years after initial diagnosis, pleural effusion and pleural dissemination were identified. The second case involved a 50-year-old woman who presented with stage IV AGCT with massive ascites and right pleural effusion. Fluid cytology from both cases showed cohesive or loose clusters of small uniform neoplastic cells with round-to-oval nuclei, coffee-bean-shaped nuclear grooves, small nucleoli, and scant cytoplasm. Call-Exner bodies were also observed in these cytologic specimens. In the differential diagnosis of small monomorphic tumor cells in pleural effusion or ascites, coffee-bean-shaped nuclear grooves and cell clusters forming Call-Exner bodies are diagnostic clues of AGCT.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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Cytologic features of ovarian granulosa cell tumors in pleural and ascitic fluids

Omori

Kondo

Yuminamochi

et al. 2015

Diagnostic Cytopathology

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“…JGCT showing tumor cells has rarely been described 13. As AGCT tends to present with a stage I disease and association with pleural effusion and ascites is about 1–2% and this rarely can exfoliate tumor cells in ascitic fluid 14, 15. Exfoliation of tumor cells in pleural fluid is even rare and has not been described previously to the best of our knowledge.…”

Section: Discussionmentioning

confidence: 96%

Adult granulosa cell tumor presenting as metastases to the pleural and peritoneal cavity

Gupta

Rajwanshi

Dey

et al. 2011

Diagnostic Cytopathology

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Ovarian tumors of sex-cord stromal derivation rarely exfoliate malignant cells in serous effusions. Adult granulosa cell tumor (AGCT) often presents as a stage I disease and association with ascites is about 10%. AGCT is rarely known to exfoliate tumor cells in the ascitic fluid. Exfoliation of malignant cells in the pleural fluid is rarer and has not been described previously in literature to the best of our knowledge. We report a case of AGCT presenting as stage IV disease with exfoliation of malignant cells in the pleural and ascitic fluid with exudative effusions. We wish to emphasize on cytomorphologic features of AGCT to differentiate the same from malignant epithelial tumors. A precise diagnosis in such a case may be possible on serous body fluid cytology with a combined clinical and cytopathologic approach.

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“…[11] Immunostaining with beta-inhibin, CD99, vimentin and cytokeratin is confirmatory of GCT. Other corroborative molecular genetic markers include somatic FOXL2 402C>G mutation, and conditional disruption in the PTEN mutation in the Kras (G12D), expressing granulosa cells.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative scrape cytology: Adult granulosa cell tumor of ovary

Deb

Malik

Sinha

2011

J Cytol

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Adult granulosa cell tumor is often a hormonally active stromal cell neoplasm of the ovary with malignant potential. Intra-operative pathological assessment is a valuable tool in guiding optimal surgical treatment in patients. Of the various intra-operative cytological diagnostic modalities, scrape smear cytology is an effective, economical, simple, fast and reliable method with results comparable with frozen section diagnosis. We describe a case of adult granulosa cell tumor in a 30-years-old lady diagnosed on intra-operative scrape cytology, and further reconfirmed on frozen section and histopathology.

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Cytomorphology of adult granulosa cell tumor in ascitic fluid

Cited by 11 publications

References 0 publications

Cytologic features of ovarian granulosa cell tumors in pleural and ascitic fluids

Cytologic features of ovarian granulosa cell tumors in pleural and ascitic fluids

Adult granulosa cell tumor presenting as metastases to the pleural and peritoneal cavity

Intraoperative scrape cytology: Adult granulosa cell tumor of ovary

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