Cytomorphology of Lipomatous Tumors of Soft Tissue

Kapila, Kusum; Ghosal, Nandita; Gill, SS; Verma, Kusum

doi:10.1159/000326568

Cited by 35 publications

(32 citation statements)

References 16 publications

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“…The specificity of background myxoid metachromatic stroma in predicting LPS has been questioned because it has been observed in a number of other nonlipomatous sarcomas. [1] The amount of myxoid material on FNA observed by Kapila et al .,[12] Kilpatrick et al .,[13] Vicandi et al . [14] correlated with the grade of the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…[3] Round cell component in MLPS are more common than initially believed. [1213] Fine needle aspiration (FNA) smears can have variable admixture of myxoid areas, round cells, and transistional areas in between, sometimes one predominating over others. [10] The aim of the study was to evaluate the cytomorphological features of RCL, which are dominated by round cells, such that a possible suspicion can be made regarding the possibility of RCL.…”

Section: Introductionmentioning

confidence: 99%

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Hypercellular round cell liposarcoma: A comprehensive cytomorphologic study and review of 8 cases

Chufal

Pant

et al. 2017

J Cytol

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Background:Myxoid and round cell liposarcomas (RCL) are low and high-grade counterparts of a common subtype of liposarcomas (LPS), representing a histologic continuum.Aims:The aim was to study the cytomorphology of hypercellular RCL and to look for features that differentiate RCL from other sarcomas displaying round cells with myxoid change.Materials and Methods:Eight cases of hypercellular RCL were identified retrospectively in which round cell component constituted greater than 75% of the area. Cytomorphological features were studied in detail.Results:Four cases were predominantly composed of round cells, out of which 2 were entirely composed of round cells. Myxoid metachromatic stroma was absent in 2 cases, while it was present in ample amounts in the remaining 6 cases. Spindle cells were completely absent in 5 cases and lipoblasts were observed in a single case of RCL. Plexiform vascular capillaries were seen in 4 cases. Adherence of neoplastic round cells around thin capillaries (ANAC) was observed in 7 cases.Conclusions:Plexiform capillary plexus and ANAC should be separately evaluated. The latter feature is the most consistent one, and is an important clue to the adipocytic nature of the neoplasm when hypercellular round cell areas are aspirated. Confident diagnosis of hypercellular RCL can be made on the basis of this feature. Lipoblasts, although specific, are seen in few cases. The rest of the features are nonspecific and useful only in combination.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hypercellular round cell liposarcoma: A comprehensive cytomorphologic study and review of 8 cases

Chufal

Pant

et al. 2017

J Cytol

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“…Unfortunately, it may not yield cells representative of the whole of the mass and requires an experienced cytologist because of its diffi cult interpretation. It, therefore, cannot be relied upon to differentiate lipoma from liposarcoma [22,23] .…”

Section: Discussionmentioning

confidence: 99%

Lipoma of the Deep Lobe of the Parotid Gland: Report of 3 Cases

Gooskens

Manni

2006

ORL

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Since lipomas are common soft-tissue neoplasms in other regions of the body, they are found only rarely in the parotid gland and are, therefore, often not considered in the initial differential diagnosis of parotid gland tumours. Even rarer are lipomas arising in the deep lobe of the parotid gland with only 6 cases presented in the literature. Lipomas originating in the parapharyngeal space are also extremely rare. When there is any suspicion, computed tomography and especially magnetic resonance imaging are of high diagnostic value. Fine-needle aspiration cytology seems not to contribute much to an accurate diagnosis. None of these preoperative examinations allows an absolute reliable distinction between a lipoma and a liposarcoma. The preferred treatment is complete surgical excision which will minimize the possibility of a recurrence and will also lead to a definitive diagnosis. We report 3 patients with a lipoma of the deep lobe of the parotid gland, extending into the parapharyngeal space, and discuss differential diagnosis and radiological features of lipomas in this rare location.

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“…Cytologic studies of hibernoma have been described, [3][4][5][6][7] but cytology may produce an erroneous diagnosis of malignancy preoperatively, usually liposarcoma. 4 Recognizing the cytomorphology of hibernomas is important.…”

Section: Introductionmentioning

confidence: 99%