Recent demand for using FBG as a pressure sensor in a different industrial application makes several types of research to be conducted to enhance the pressure sensitivity. This paper demonstrates a combination method to enhance pressure sensitivity. Firstly, in this work FBG with polymer fiber named perfluorinated monomer (CYTOP) was used with specific parameters. Secondly, this FBG was covered by a patch of thin polymer material. However, the strain, temperature, and pressure sensitivity were recorded and compared with bare silica FBG. The temperature effect was reduced by using the cascade FBG technique. By applying force on the grating and changing of refractive index; the Bragg wavelength was shifting, making the CYTOP FBG responds more efficiently than silica FBG. This responsivity was leading to an improvement in pressure sensitivity. Experimental results illustrate that the enhanced CYTOP FBG based pressure sensor achieves pressure sensitivity up to 93.5 pm/KPs with a resolution of 0.005 KPa, which was 1500 times higher than bare FBG. The advanced CYTOP FBG based pressure sensor can be functionalized in a technical application for instance, structural health monitoring, pressure of oil wells application, explosion wave, and prevention of erosion.