Cytopathologic features of papillary glioneuronal tumor

Doxtader, Erika E.; Sturgis, Charles D.

doi:10.1002/dc.23885

Cited by 8 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They may additionally present calcifications or have a hemorrhagic component, as well as be associated with edema or mass effect if the lesions are large. 7 According to the WHO 2016 central nervous system tumor classification, this tumor is located in the section of mixed neuronal and glioneural tumors. It is characterized by a prominent pseudo papillary architecture, a single or pseudo-stratified layer of flattened or cuboidal glial cells with round nuclei and scant cytoplasm, located around hyalinized blood vessels together with intervening collections of neurocytes and medium-sized ganglion cells with accompanying neuropil.…”

Section: Discussionmentioning

confidence: 99%

Papillary glioneural tumor presenting with multiple ischemic strokes: an aggressive presentation of a “benign” entity

et al. 2021

View full text Add to dashboard Cite

Papillary glioneural tumors are infrequent neoplasms of the central nervous system, classically presenting with an indolent clinical course, rarely being related to an aggressive presentation, and not being associated with ischemic or another type of paraneoplastic phenomena. We describe the first case of this type of presentation with a literature review of the current knowledge of this entity. A 16-year-old female presented with a hemorrhagic intra-axial lesion, confirmed to be a papillary glioneural tumor in the histopathological analysis, being associated with multiple ischemic cerebral and posterior fossa strokes without another discernable cause than the presence of a paraneoplastic syndrome, not previously reported with this type of neoplasms. A literature review is presented detailing the current knowledge about this entity and emphasizing the need for greater knowledge about its natural history, immunobiology and treatment alternatives, opening a new window for the study of this pathology and establishing the need for a strict follow-up of patients who have this kind of tumors in order to learn more about their evolution. The papillary glioneural tumor, a rare entity having generally with a benign course, can have different presentations. Greater knowledge is needed to understand this behavior in order to optimize patient’s outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Papillary glioneural tumor presenting with multiple ischemic strokes: an aggressive presentation of a “benign” entity

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Only 150 cases of PGNTs are reported up to now in the literature [36,31,17,11,41,15,12,2]. Amongst these, only 41 cases are reported in pediatric population which demonstrates rarity of this pathology in this age group [11,43,44,32,35,29,26,8,1,42,30,33,28,34,20,18,19,14,16,3,39,13,10,38,7,25,9,4,23].…”

Section: Background and Importancementioning

confidence: 99%

Section: Histopathologymentioning

confidence: 99%

Acute presentation of papillary glioneuronal tumor due to intra-tumoral hemorrhage in a toddler: an odd presentation of a rare pathology

Tavallaii

Keykhosravi

Rezaee

2020

British Journal of Neurosurgery

View full text Add to dashboard Cite

Background and Importance: Papillary glioneuronal tumor is a recently known entity in central nervous system tumors. These benign WHO grade I tumors are mostly seen in young adults. Pediatric PGNT is rare and there is no report of these tumors in toddlers. Headache, nausea/vomiting and seizure are most common clinical symptoms. Acute presentation with focal neurological deficits or loss of consciousness are not amongst the expected presentations. These tumors are typically cystic with enhancing mural nodule. Although case with chronic intermittent microhemorrhages are reported in the literature but overt intra-tumoral hemorrhage is an odd radiological presentation with just one reported case in the literature. Clinical presentation: We present an extremely rare case of PGNT presenting with sudden onset hemiparesis and impaired consciousness due to acute intra-tumoral hemorrhage in a toddler which was surgically treated with favorable outcome. Conclusion: PGNTs can also be seen in very young children even in toddlers. Also, it should be kept in mind that these tumors have potential for overt intra-tumoral hemorrhage and acute presentation with focal neurological deficits mimicking more common pathologies which should be considered to plan optimal patient management.

show abstract

“…The morphologic characteristics are pseudopapillae composed of hyalinized blood vessels with single or multiple lining layers of cuboidal cells. There is case to case difference in proportion of glial and neuronal elements [23,12]. However, these tumors may resemble ganglioglioma, pleomorphic xanthoastrocytoma, pilocytic astrocytoma and dysembryoplastic neuroepithelial tumor in histopathological examinations [4].…”

Section: Histopathologymentioning

confidence: 99%

Acute presentation of papillary glioneuronal tumor due to intra-tumoral hemorrhage in a toddler: An odd presentation of a rare pathology

Tavallaii

Keykhosravi

Rezaee

2020

Preprint

View full text Add to dashboard Cite

Background and Importance: Papillary glioneuronal tumor is a recently known entity in central nervous system tumors. These benign WHO grade I tumors are mostly seen in young adults. Pediatric PGNT is rare and there is no report of these tumors in toddlers. Headache, nausea/vomiting and seizure are most common clinical symptoms. Acute presentation with focal neurological deficits or loss of consciousness are not amongst the expected presentations. These tumors are typically cystic with enhancing mural nodule. Although case with chronic intermittent microhemorrhages are reported in the literature but overt intra-tumoral hemorrhage is an odd radiological presentation with just one reported case in the literature.Clinical presentation: We present an extremely rare case of PGNT presenting with sudden onset hemiparesis and impaired consciousness due to acute intra-tumoral hemorrhage in a toddler which was surgically treated with favorable outcome.Conclusion: PGNTs can also be seen in very young children even in toddlers. Also, it should be kept in mind that these tumors have potential for overt intra-tumoral hemorrhage and acute presentation with focal neurological deficits mimicking more common pathologies which should be considered to plan optimal patient management.

show abstract

Cytopathologic features of papillary glioneuronal tumor

Cited by 8 publications

References 4 publications

Papillary glioneural tumor presenting with multiple ischemic strokes: an aggressive presentation of a “benign” entity

Papillary glioneural tumor presenting with multiple ischemic strokes: an aggressive presentation of a “benign” entity

Acute presentation of papillary glioneuronal tumor due to intra-tumoral hemorrhage in a toddler: an odd presentation of a rare pathology

Acute presentation of papillary glioneuronal tumor due to intra-tumoral hemorrhage in a toddler: An odd presentation of a rare pathology

Contact Info

Product

Resources

About