1978
DOI: 10.1016/s0074-7696(08)60753-6
|View full text |Cite
|
Sign up to set email alerts
|

Cytophysiology of Thyroid Parafollicular Cells

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

2
24
0

Year Published

1980
1980
2015
2015

Publication Types

Select...
9

Relationship

1
8

Authors

Journals

citations
Cited by 56 publications
(26 citation statements)
references
References 309 publications
2
24
0
Order By: Relevance
“…This is different from other mammals such as cat, dog, rabbit and rat were they are numerous (Lupulescu & Petrovici, 1968) and in deer thyroid (Pantic, 1967) and many mammalian hibernators, but they are very rare in many primates including human thyroids (Nunez & Gershon, 1978). The role of parafollicular cells in calcium metabolism through calcitonin in most mammals studied is most likely similar in WAD goats.…”
Section: Discussionmentioning
confidence: 85%
“…This is different from other mammals such as cat, dog, rabbit and rat were they are numerous (Lupulescu & Petrovici, 1968) and in deer thyroid (Pantic, 1967) and many mammalian hibernators, but they are very rare in many primates including human thyroids (Nunez & Gershon, 1978). The role of parafollicular cells in calcium metabolism through calcitonin in most mammals studied is most likely similar in WAD goats.…”
Section: Discussionmentioning
confidence: 85%
“…As a result, PF cells secrete both transmitters when stimulated by their natural secretogogue, increased extracellular Ca 2ϩ (1[Ca 2ϩ ] e ) (Nunez and Gershon, 1978). PF cells are able to respond to 1 [Ca 2ϩ ] e because they express a plasmalemmal Ca 2ϩ receptor (CaR) that is activated by changes in the extracellular Ca 2ϩ concentration and polyamines, such as protamine (Herbert and Brown, 1995;Tamir et al, 1996).…”
mentioning
confidence: 99%
“…Increases in serum Ca¥ stimulate parafollicular cells of the thyroid gland (PF cells) to release calcitonin (CT) and serotonin (5_HT) (Nunez & Gershon, 1978). PF cells, along with those of the parathyroid gland, are able to detect ambient Ca¥ levels and this sensitivity controls the release of the hormones that regulate calcium homeostasis.…”
mentioning
confidence: 99%
“…While CT affects distant targets to influence Ca¥ homeostasis, 5_HT acts locally to regulate follicular cells (Tamir et al , 1996. PF cells are localized within the basal lamina surrounding each follicle of the thyroid (Nunez & Gershon, 1978) and their relatively low abundance has hindered detailed physiological analyses. Instead, medullary thyroid carcinoma (MTC) cell lines, which are derived from PF cells and are also sensitive to increases in [Ca¥]ï, have been used as models for PF cell biochemical and biophysical characteristics (Muff et al 1988;Yamashita & Hagiwara 1990;Fajtova, Quinn & Brown, 1991;Mekonnen, Raue & Ziegler, 1992;DeReimer, Hsiung & Tamir, 1992;Scherubl, Kleppisch, Zink, Raue, Krautwurst & Hescheler, 1993; for a review see Nelkin, 1996).…”
mentioning
confidence: 99%