Cytoplasmic and nuclear estrogen binding capacity in the rat uterus during treatment with danazol and testosterone

Cano, Antonio; Morcillo, Nieves; Lopez, Fe; Marquina, Pilar; Parrilla, Juan José; Abad, Lorenzo

doi:10.1016/0028-2243(86)90024-9

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…With suppressed T concentrations, perhaps ER sensitivity is reduced, resulting in slightly depressed VTG production. A few reports of in vivo T treatment enhancing estrogen-binding capacity in rodents lend some support to this idea ( Cano et al 1986 ; Ho and Yu 1993 ; Jaubert et al 1995 ).…”

Section: Discussionmentioning

confidence: 94%

Reproductive Disruption in Wild Longear Sunfish ( Lepomis megalotis ) Exposed to Kraft Mill Effluent

Fentress

Steele

Bart

et al. 2006

Environ Health Perspect

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Worldwide, wild fish living in rivers receiving municipal and industrial discharges may experience endocrine disruption as a result of exposure to anthropogenic pollutants. The purpose of this study was to evaluate the hormonal status of wild fish in a U.S. river receiving unbleached kraft and recycled pulp mill effluent (Pearl River at Bogalusa, LA). We evaluated two alternative hypotheses: the effluent contained constituents that suppressed male and female reproduction, or it contained an androgenic substance that masculinized females. To evaluate the likelihood of fish exposure to effluent, we marked 697 longear sunfish (Lepomis megalotis) over a 2-year period; 83% of recaptured fish were found at the site of initial capture, and only one fish migrated from an effluent-receiving site to a reference site. We can reasonably assume that fish captured from an effluent-receiving site are residents, not transitory migrants. To diagnose endocrine disruption, we measured sex steroid hormone [17β-estradiol (E2), testosterone (T), and 11-ketotestosterone (11KT)] and vitellogenin (VTG) concentrations in male and female longear sunfish captured at two sites upstream and two sites downstream of the effluent outfall. Kraft pulp mill effluent did not affect male reproductive physiology but did suppress female T and VTG levels when effluent constituted ≥ 1% of river flow. Masculinization was not observed. Longear sunfish in the Pearl River experience moderate reproductive suppression in response to unbleached kraft and recycled pulp mill effluent.

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Section: Discussionmentioning

confidence: 94%

Reproductive Disruption in Wild Longear Sunfish ( Lepomis megalotis ) Exposed to Kraft Mill Effluent

Fentress

Steele

Bart

et al. 2006

Environ Health Perspect

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“…ER show structural components that may be involved in their particular action mechanism. One of the most striking domain is the ligand binding domain (LBD) that interacts with specific ligands [163] (Cano et al, 2006). It is believed that the high or low affinity of the ligand with LBD plays a central role in the function of ER.…”

Section: Selective Estrogen Receptor Modulatorsmentioning

confidence: 99%

Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions

Toro-Urrego¹,

Ávila-Rodriguez²,

Herrera³

et al. 2020

Neuroprotection - New Approaches and Prospects

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Hypoxic–ischemic brain injury is a number one cause of long-term neurologic disability and death worldwide. This public health burden is mainly characterized by a decrease in oxygen concentration and blood flow to the tissues, which lead to an inefficient supply of nutrients to the brain. This condition induces cell death by energy depletion and increases free radical generation and inflammation. Hypoxic–ischemic brain injury may occur in ischemic-stroke and over perinatal asphyxia, being both leading causes of morbidity in adults and children, respectively. Currently, there are no effective pharmaceutical strategies to prevent the triggering of secondary injury cascades, including oxidative stress and metabolic dysfunction. Neuroactive steroids like selective estrogen receptor modulators, SERMs, and selective tissue estrogenic activity regulators, STEARs, exert several neuroprotective effects. These encompass mitochondrial survival, a decrease in reactive oxygen species, and maintenance of cell viability, among others. In this context, these neurosteroids constitute promising molecules, which could modify brain response to injury. Here we show an updated overview of the underlying mechanisms of hypoxic–ischemic brain injury. We also highlight the neuroprotective effects of neurosteroids and their future directions.

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Oestrogen and progesterone receptors in human term placenta. Measurement by binding assays and immunological methods

Rivera

Cano

1989

Placenta

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Cytoplasmic and nuclear estrogen binding capacity in the rat uterus during treatment with danazol and testosterone

Cited by 5 publications

References 17 publications

Reproductive Disruption in Wild Longear Sunfish ( Lepomis megalotis ) Exposed to Kraft Mill Effluent

Reproductive Disruption in Wild Longear Sunfish ( Lepomis megalotis ) Exposed to Kraft Mill Effluent

Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions

Oestrogen and progesterone receptors in human term placenta. Measurement by binding assays and immunological methods

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