Cytoprotective effect of trimetazidine on 60 minutes of intestinal ischemia-reperfusion injury in rats

Tetik, Cihat; Özden, Akın; Çallı, Neşe; Bi̇lgi̇han, Ayşe; Bostancı, Birol; Yis, Özgür Mehmet; Bayramoǧlu, Hati̇ce

doi:10.1111/j.1432-2277.1999.tb00589.x

Cited by 42 publications

(20 citation statements)

References 20 publications

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“…MPO activity was assessed by measuring the H 2 O 2 ‐dependent oxidation of O ‐dianisidin. One unit of enzyme activity was defined as amount of MPO present that caused a change in absorbance of 1.0/min at 410 nm and 37°C 27 . The determination of GSH‐Px activity was based on the method of Paglia and Valentine 28 .…”

Section: Methodsmentioning

confidence: 99%

Effect of Bencyclane Fumarate on Intestinal Ischaemia Reperfusion Injury

Barut

Tarhan

Kapucuoğlu

et al. 2008

ANZ Journal of Surgery

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Section: Methodsmentioning

confidence: 99%

Effect of Bencyclane Fumarate on Intestinal Ischaemia Reperfusion Injury

Barut

Tarhan

Kapucuoğlu

et al. 2008

ANZ Journal of Surgery

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“…TMZ (Vastarel, Servier, France), 3 mg/kg diluted in 3 ml 0.9% NaCl solution, was administered intraperitoneally either 30 min before ischemia or 5 min before reperfusion. This dosage of TMZ had been used preferentially in several experimental animal models [17, 18, 19, 20]. …”

Section: Methodsmentioning

confidence: 99%

“…TMZ also inhibits platelet adhesion-aggregation, neutrophil infiltration and the generation or activity of oxygen-derived free radicals [14, 15]. TMZ has been used to protect I/R injury of the myocardium [16], kidney [17, 18], intestine [19]and liver [20]. However, there was no report on the use of TMZ in retinal I/R injury.…”

Section: Introductionmentioning

confidence: 99%

Effect of Trimetazidine on Retinal Ischemia/Reperfusion Injury in Rats

Özden

Kildaci²,

Müftüoğlu³

et al. 2001

Ophthalmologica

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Purpose: To investigate the effect of trimetazidine (TMZ), an antioxidant agent, on the ischemia/reperfusion (I/R) injury in rat retina histopathologically. Methods: The retinal I/R model was carried out by the 4-vessel occlusion method on Wistar albino rats. Twenty-one rats were divided into 7 groups, each comprising 3 rats. The animals in groups 1, 2 and 3 underwent 30 min of ischemia + 4 h of reperfusion and were treated by the administration of saline, TMZ before reperfusion and TMZ before ischemia, respectively. The animals in groups 4, 5 and 6 underwent 90 min of ischemia + 4 h of reperfusion and were treated in the same way as those in groups 1, 2 and 3, respectively. The 7th group was sham operated. Results: Thirty and 90 min of ischemia followed by 4 h of reperfusion induced retinal injury in the rat retina. Histopathologically, the inner plexiform and inner nuclear layers were the most affected parts. TMZ was able to reduce almost all retinal I/R damage when administered before ischemia. A cytoprotective effect of TMZ was partly observed in those animals which were treated before reperfusion. Conclusion: TMZ seemed to have a protective effect against retinal I/R injury in rats.

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“…TMZ has been shown in experimental animal models to be beneficial against ischemia in several organs including the heart and the brain, peripheral nerves, inner ear, kidney, lung, bowel, liver, and stomach [15][16][17][18][19][20][21][22] . Despite the clearly-defined antiischemic effects of the TMZ, there are a limited number of studies in the literature on the potential effects of TMZ in epileptic seizures or convulsions 10,23 .…”

Section: Introductionmentioning

confidence: 99%

Acute Administration of High Dose Trimetazidine Inhibits Pentylenetetrazol-Induced Seizures in Rats

Gürgül¹,

Erten

Gül³

et al. 2017

Cumhuriyet Medical Journal

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SUMMARYObjective: Resistant epilepsy is widely seen in clinical settings manipulate the researchers to pursuit novel anti-epileptic treatments. Although trimetazidine (TMZ) is commonly used in the treatment of angina and ischemic diseases, it is considered that the drug may be beneficial in the treatment of epileptic seizures and convulsions. We aimed to evaluate electrophysiologically the protective effects of high dose acute TMZ on epileptic seizures and convulsions in a rat model of epilepsy induced by pentilentetrazol (PTZ). Method: Forty-eight male Sprague-Dawley rats were used for the EEG evaluation (Group-A; n=24) and behavioral assessment (Group-B; n=24). Grup-A1 and Grup-B1 were determined as control group and given no medication. 35 mg/kg (Group-A2, -A3 and -A4) and 70 mg/kg (Group-B2, -B3 and -B4) of PTZ were administered intraperitoneally (ip.) so as to generate seizures and convulsions. Group-A2 and Group-B2 were treated with saline. 40 mg/kg (Grup-A3 and Grup-B3) and 80 mg/kg of TMZ (Group-A4 and Group-B4) were administered to the treatment groups by ip. Brain malondialdehyde (MDA) levels, spike-percentage values, Racine's Convulsion Scale (RCS) scores and "first myoclonic jerk (FMJ)" latencies of each rat were determined. Results: Brain MDA levels, spike-percentage values, RCS scores, and FMJ latencies of Group-A2 and Group-B2 were significantly increased compared to those of the control's (Grup-A1 and Grup-B1) (P<0.05 for all comparisons). However, in TMZ treated groups (Group-A3 and -A4; Group-B3 and -B4) the elevated values of these parameters were found to be significantly decreased (P<0.05 for all comparisons). Conclusions:This study has demonstrated that the high dose acute TMZ administration may prevent PTZ-induced seizures and convulsions in rats. Furthermore, it can be also said that TMZ has a neuroprotective effects on oxidative stress associated with PTZ. Therefore, it may be considered for use with therapeutic purposes of TMZ in resistant epilepsy patients in the future. Keywords: Electroencephalography (EEG), Epilepsy, Malondialdehyde, Pentylenetetrazol, Rat, Trimetazidine.ÖZET Amaç: İlaca-dirençli epilepsi, klinikte yaygın olarak görülen ve araştırmacıları yeni anti-epileptik tedavilerin saptanması için harekete geçiren bir durumdur. Trimetazidin (TMZ) anjina ve iskemik hastalıkların tedavisinde yaygın olarak kullanılmasına rağmen, epileptik nöbetler ve konvülsiyonların tedavisinde de yararlı olabileceği düşünülmektedir. Bu çalışmada, pentilentetrazol (PTZ) ile indüklenen bir sıçan epilepsi modelinde yüksek doz akut TMZ'nin epileptik nöbetler ve konvülsiyonlar üzerine koruyucu etkilerini elektrofizyolojik parametreler açısından değerlendirmeyi amaçladık. 381Yöntem: 48 adet erkek Sprague-Dawley cinsi sıçan EEG (Group-A; n=24) ve davranış analizlerinde (Group-B; n=24) kullanıldı. Grup-A1 ve Grup-B1 kontrol grubu olarak belirlendi ve ilaç verilmedi. 35 mg/kg (Group-A2, -A3 ve -A4) ve 70 mg/kg PTZ (Group-B2, -B3 ve -B4), nöbet ve konvülsiyon oluşturmak amacıyla, intraperitoneal olarak (i...

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Cytoprotective effect of trimetazidine on 60 minutes of intestinal ischemia-reperfusion injury in rats

Cited by 42 publications

References 20 publications

Effect of Bencyclane Fumarate on Intestinal Ischaemia Reperfusion Injury

Effect of Bencyclane Fumarate on Intestinal Ischaemia Reperfusion Injury

Effect of Trimetazidine on Retinal Ischemia/Reperfusion Injury in Rats

Acute Administration of High Dose Trimetazidine Inhibits Pentylenetetrazol-Induced Seizures in Rats

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