Cytoprotective effects of catechin 7‐O‐β‐D glucopyranoside against mitochondrial dysfunction damaged by streptozotocin in RINm5F cells

Abstract

The protective effects of catechin 7-O-β-D glucopyranoside (C7G) against streptozotocin (STZ)-induced mitochondrial damage in rat pancreatic β-cells (RINm5F) were investigated. A marked increase in mitochondrial reactive oxygen species (ROS) was observed in STZ-treated cells; this increase was restricted by C7G treatment. C7G also scavenged superoxide anions and hydroxyl radicals generated by xanthine/xanthine oxidase (xanthine/XO) and the Fenton reaction (FeSO(4) + H(2) O(2)), respectively. C7G restored activity and expression of both mitochondrial manganese superoxide dismutase (MnSOD) and catalase (CAT), which were suppressed by STZ treatment. In addition, C7G prevented STZ-induced mitochondrial lipid peroxidation, protein carbonyl, and DNA base modification. C7G restored the loss of mitochondrial membrane potential (Δψ) that was disrupted by STZ treatment, and prevented cell death via inhibition of apoptosis. These results suggest that C7G has a protective effect against STZ-induced cell damage by its antioxidant effects and the attenuation of mitochondrial dysfunction.

Parkia biglobosaImproves Mitochondrial Functioning and Protects against Neurotoxic Agents in Rat Brain Hippocampal Slices

“…Catechin polyphenols in green tea were identified to be paramount to the neuroprotective properties of the green tea plant majorly through their strong antioxidant, free radical scavenging, and metal ion chelating activities [38]. They could also exhibit beneficial effects on the mitochondrial redox status [39, 40]. …”

Investigation through Bangladesh Flora: Critically Endangered Medicinal Species of Fabaceae

“…The previously collected specimens of Fabaceae preserved in different herbaria of Bangladesh, viz., BNH (Bangladesh National Herbarium), DUSH (Dhaka University Salar Khan Herbarium), BFRIH (Bangladesh Forest Research Institute Herbarium), BCSIRH (Herbarium, Bangladesh Council of Scientific and Industrial Research), HCU (Herbarium of Chittagong University), have been examined critically to record the data of each species. The relevant and up to date floristic literature published since Sinclair (1956), such as, Khan and Afza (1968), Khan and Banu (1972), Khan et al (1984), Huq and Begum (1984), Huq (1988), Khan et al (1996), Rahman and Uddin (1997), Yusuf et al (1997), Dey et al (1998), Uddin and Rahman (1999), Das and Alam (2001), Khan and Huq (2001) Determination of the recorded species as medicinal have been made by consulting medicinal books and published articles, e.g., Dunn (1912), Gillett (1958), De Kort andThijsse (1984), Ambasta (1986), Kaur and Kapoor (1990), Jain (1991), Ghani (2003), Yusuf et al (2009), Kim et al (2010), Quattrocchi (2012), Ren et al (2019), Arvind Kumar et al (2017).…”