Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: Where do we stand?

The landscape of cancer treatment has evolved significantly with the integration of multimodal approaches, wherein surgery plays a pivotal role. This comprehensive review examines the dynamic role of surgical interventions within the framework of multimodal cancer therapy, highlighting historical advancements, innovative surgical techniques, and their synergistic effects with other treatment modalities. We explore preoperative, intraoperative, and postoperative considerations, emphasizing patient selection, technological innovations, and multidisciplinary collaboration. Through case studies and clinical trials, we illustrate the efficacy and challenges of combining surgery with chemotherapy, radiotherapy, and emerging therapies. Addressing controversies and future trends, this review underscores the necessity of personalized and precision medicine in enhancing patient outcomes. The insights provided aim to guide clinicians and researchers in optimizing surgical strategies within the multifaceted landscape of cancer care.

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Addressing the Rising Trend in Early-Age-Onset Cancers in Canada

Wildgoose,

Servidio-Italiano,

Raphael

et al. 2024

Current Oncology

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A multi-disciplinary symposium on early-age onset cancer (EAOC) was held in October 2023 to explore challenges experienced by this rapidly growing population. A major outcome of the symposium was recognition of the remarkable similarities of EAOC patients’ journeys across cancer sites. Prevention and early detection of cancer are hindered by a lack of awareness among patients and family doctors that cancer can and does occur in younger persons. Distinct characteristics of the disease—such as a later stage at diagnosis and more aggressive tumor biology—require more potent treatments, which result in profound physical and psychosocial consequences that are unique to this age group. EAOC patient empowerment emerged as another key theme of the symposium. The development of a greater number of specialized clinics was called for, and patient support groups were recognized for the vital role they play in empowering patients and their families. Leading-edge medical advancements hold tremendous hope across the spectrum of EAOC care. New technologies based on genomic profiling, immunotherapy and microbiome alteration contribute to the development of highly effective, personalized approaches to treatment. All symposium participants expressed their commitment to speak with one resounding voice to advocate for equitable access to leading care practices for EAOC patients; thus, a fourth symposium is planned for November 2024.

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Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: Where do we stand?

Abstract: Plain Language Summary Patients with colorectal cancer that has spread to the lining of the abdomen (peritoneum) benefit from surgery to remove all the cancer. The addition of certain types of intra‐abdominal chemotherapy during surgery improves survival for select patients.

Cited by 3 publications

References 71 publications