Cytoreductive Surgery With Intraperitoneal Chemohyperthermia for the Treatment of Pseudomyxoma Peritonei: A Prospective Study

Abstract

Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy is a feasible treatment for pseudomyxoma peritonei. It is associated with acceptable morbidity when performed by an experienced surgical team. Histologic grade is the major determinant of survival.

Complications of Cytoreductive Surgery and HIPEC in the Treatment of Peritoneal Metastases

“…Several factors have been analyzed as predictive factors of moderate to severe morbidity following CRS and HIPEC such as sex [35], age, primary colonic anastomosis, number of peritonectomy procedures [10,14,15,28,42], number of visceral resections [10,14,28], number of anastomosis [10], incomplete cytoreduction, disruption of the umbilical fissure [43], dose of chemotherapeutic agent [15], intra-abdominal HIPEC temperature and histopathologic grade [42].…”

Novel Insights into Fur Regulation in Helicobacter pylori

“…As described by (22). Despite the relatively few genes that were characterized in detail in those previous studies, it is clear that regulatory overlap occurs within H. pylori adaptive responses.…”

“…Numerous studies have identified a role for Fur regulation in numerous adaptive responses in vitro, as well as in vivo colonization (22,67) and disease development (111).…”

“…Mortality usually results from diffuse spread of mucin within the peritoneum and mechanical obstruction of the intestines. PMP is generally classified into two major categories: diffuse peritoneal adenomucinosis (DPAM) and peritoneal mucinous adenocarcinoma (PMCA) (21,22,27). DPAM is the lower grade of PMP disease and refers to an indolent tumor form without cellular atypia and no invasive features.…”

Abdominal Advanced Oncologic Surgery

“…Results are encouraging with a 5-ys-OS ranging from 62.5 to 100% for low grade PMP and from 0 to 65% for high grade disease . This differentiation is crucial for the evolution of disease; low grade tumours are slow growing and indolent differently from those high grade, fast growing and aggressive (Sugarbaker and Chang, 1999;Witkamp et al, 2001;Güner et al, 2005;Moran et al, 2008;Moran and Cecil, 2003;Murphy et al, 2007;Baratti et al, 2008;Elias et al, 2008;Loungnarath et al, 2005;Smeenk et al, 2007;Stewart et al, 2005;Yan et al, 2006). The goal of the surgical cytoreduction is to remove all the visible tumor by the following procedures: right subdiaphragmatic and parietal peritonectomy, left subdiaphragmatic and parietal peritonectomy,greater omentectomy with splenectomy, lesser omentectomy and stripping of the omental bursa, andpelvic peritonectomy with salpingo-oophorectomy in women.…”