2002
DOI: 10.1155/mbd.2002.333
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Cytotoxic Activities of O‐Cholesteryl‐O‐Phenyl‐N‐Phenylphosphoramidate and ItsOrganometallic Tin(lV) Derivatives

Abstract: O-Cholesteryl-O-phenyl-N-phenylphosphoramidate (1) and four organotin (lV) derivatives of the ambidentate O-cholesteryl-O -phenyl phosphorothioate ligand formulated as Me3 SnOSPR’R”(2), Ph3SnOSPR’R”(3), O(CH2CH2S)2Sn(n-Bu)OSPR’R”(4), S(CH2CH2S)2Sn(n-Bu)OSPR’R”(5), (R’ = O-phenyl; R”= O-cholesteryl) were subjected to cytotoxicity screening against KB (nasopharingel carcinoma), OVCAR-5 (ovarium carcinoma) and SQC-1 UlSO (squamous cell cervix carcinoma) cell cultures. The results of the bioassay showed that these… Show more

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