Cytotoxic Activity and Related Mechanisms of Prenylflavonoids Isolated from<i>Mallotus conspurcatus</i><scp>Croizat</scp>

Zhang, Yanjun; Zhou, Dexiong; Liu, Wei; Li, Chengguo; Hao, Lili; Zhang, Gaorong; Deng, Shengping; Yang, Ronghua; Qin, Jiang Ke; Li, Jun; Deng, Wei

doi:10.1002/cbdv.201800465

Cited by 7 publications

(4 citation statements)

References 38 publications

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“…Some studies have reported differential impacts of 8-PN on malign and normal cells. For example, 8-PN and 6-PN displayed cytotoxic activity against the HeLa cervical cancer cells (with IC 50 values ranging from 10 to 60 μM), but were less toxic to normal HL-7702 cells [ 141 ]. Similarly, 8-PN exhibited a strong growth inhibitory effect on human colorectal carcinoma HCT-116 cells with an IC 50 value of 24 μg/mL after 48 h. However, at similar concentrations and experimental timepoints, the compound did not show any cytotoxic effect to non-cancerous colon cells (CCD-41) [ 142 ].…”

Section: Effects On Tumor Cells In Vitromentioning

confidence: 99%

The Potent Phytoestrogen 8-Prenylnaringenin: A Friend or a Foe?

Pohjanvirta

Nasri

2022

IJMS

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8-prenylnaringenin (8-PN) is a prenylated flavonoid, occurring, in particular, in hop, but also in other plants. It has proven to be one of the most potent phytoestrogens in vitro known to date, and in the past 20 years, research has unveiled new effects triggered by it in biological systems. These findings have aroused the hopes, expectations, and enthusiasm of a “wonder-drug” for a host of human diseases. However, the majority of 8-PN effects require such high concentrations that they cannot be reached by normal dietary exposure, only pharmacologically; thus, adverse impacts may also emerge. Here, we provide a comprehensive and up-to-date review on this fascinating compound, with special reference to the range of beneficial and untoward health consequences that may ensue from exposure to it.

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Section: Effects On Tumor Cells In Vitromentioning

confidence: 99%

The Potent Phytoestrogen 8-Prenylnaringenin: A Friend or a Foe?

Pohjanvirta

Nasri

2022

IJMS

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“…Nanoparticles of copper oxide that are usually produced from Azadirachta indica, Murraya koenigii, Tamarindus indica, Hibiscus rosasinensis and Moringa oleifera. These nanoparticles when introduced in HeLa cells showed various anti-cancer properties that include triggering apoptosis and inhibiting oxidant [46][47][48]. When HeLa cells are treated with a cocktail of polymeric micelles and TPGS/F127/P123 coupled with curcumin extracted from Curcuma longa [49].…”

Section: Various Natural Compoundsmentioning

confidence: 99%

Therapeutic Effects of Natural Products Isolated from Different Microorganisms in Treating Cervical Cancer: A Review

Mukherjee

Lahiri

Nag

2022

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Cervical cancer is defined as a cancer arising in the cells of cervix that causes unusual vaginal bleeding, discharges, pain in the pelvic region, or pain during sexual activity. Cervical cancer is currently reported to be the fourth most prevalent malignancy among women globally. Surgery includes pelvic lymphadenectomy as well as radical hysterectomy, radiotherapy, as well as chemotherapy are the most common therapies for treating cervical cancer. Another approach includes targeted medication which affects the epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) for the curing cervical cancer. However, these therapies have the potential for risks and complications: surgery can result in bleeding and may cause organ damage surrounding the surgery, and clots may also start to form in the deep veins of the legs; radiotherapy can result in menopause, infertility, discomfort, or pain during intercourse; and chemotherapy can actually impact rapidly dividing cells along with cancer cells in the human body system. In this review, we will discuss about the use of several Randomised controlled trials (RCTs) for treating malnutrition in various oncology patients. In this review, we will discuss about the various therapeutic effects of natural products isolated from different microorganisms in treating cervical cancer.

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“…Compounds 112, 126, and 140 showed significant cytotoxic activity against the A2780 human ovarian cancer cell line (IC 50 6.3±0.4, 1.10±0.05, and 1.3±0.1 µM, respectively) [15,51]. Recently, five prenylflavonoids, 6-prenylnaringenin (52), 7-O-methyl-6-prenylnaringenin (53), 4′-O-methyl-6prenylnaringenin (54), 7-O-methyl-8-prenylnaringenin (55), and 8-prenylnaringenin (59) obtained from M. conspurcatus exhibited cervical cancer (HeLa) cells with IC 50 values ranging from 10.08 to 60.16 µM [29].…”

Section: Cytotoxic and Antitumor Activitiesmentioning

confidence: 99%

Genus mallotus (euphorbiaceae): a review on traditional medicinal use, phytochemistry and biological activities

Anh

Park

Trang³

et al. 2022

Vietnam J. Sci. Technol.

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Ethnopharmacological relevance: The genus Mallotus (Euphorbiaceae family) includes 124 accepted names and distributes in tropical and sub-tropical regions. Some Mallotus species are used in traditional medicines for the treatment of chronic hepatitis, enteritis stomach, disorders, cholelithiasis, anti-cancer, gastric, and duodenal ulcers. Aim of the study: According to the Scifinder database, this is the first review study that focuses on the phytochemistry and pharmacology of Mallotus genus (17 Mallotus species) to understand the link between the traditional medicinal uses, phytochemistry, and bioactivities. Thus, they provides a scientific fundamental for further research in the phytochemical and pharmacological activities of their species. Materials and methods: Information about the Mallotus genus was collected using various databases, such as Web of Science, SciFinder, PubMed, Sci-hub, Google Scholar, Wiley, Elsevier, ACS publications, and SpringerLink between 1978 and 2021. Plant names were validated by “The Plant List” (www.theplantlist.org). Results: Up to now, total 325 compounds were reported from Mallotus species, including phloroglucinols, steroids, coumarins, benzopyrans, flavonoids, chalcones, galics, and bergenins. The extracts and phytochemical constituents of the Mallotus genus are a rich source of biologically active, including anti-cancer, anti-inflammatory, immunoregulatory, antioxidant, antibacterial, antifungal, anti-virus, and other activities. Conclusions: The review indicated that the Mallotus genus is a promising source of biological activities compounds, special anti-cancer chromanes. The results of this review confirm the great potential of Mallotus species. Thus, it will be helpful for further research in the phytochemistry and pharmacology of the Mallotus genus.

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Cytotoxic Activity and Related Mechanisms of Prenylflavonoids Isolated fromMallotus conspurcatusCroizat

Cited by 7 publications

References 38 publications

The Potent Phytoestrogen 8-Prenylnaringenin: A Friend or a Foe?

The Potent Phytoestrogen 8-Prenylnaringenin: A Friend or a Foe?

Therapeutic Effects of Natural Products Isolated from Different Microorganisms in Treating Cervical Cancer: A Review

Genus mallotus (euphorbiaceae): a review on traditional medicinal use, phytochemistry and biological activities

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