Cytotoxic activity of alkyl benzoate and fatty acids from the red sea spongeHyrtios erectus

Abstract

The chemical investigation of the methylene chloride fraction of marine sponge Hyrtios erectus led to the isolation of the known oxysterol (2) along with a new alkyl benzoate compound identified by spectroscopic methods (NMR and MS) as 4'-methylheptyl benzoate (1), whilst the n-butanol fraction afforded the known indole 3-carbaldehyde and β-carboline derivatives. Moreover, the hexane fraction was analysed by GC-MS for their fatty acids (FAs). A total of 17 FAs with chain lengths between 14 and 25 carbons were identified. Methyl-branched FAs are predominated suggesting the presence of bacterial symbionts in the H. erectus sponge. Furthermore, compounds 1 and 2 displayed significant cytotoxicity against breast adenocarcinoma (MCF-7) with IC values of 2.4 and 3.8 μM, respectively, since compound 2 was also shown to have potent cytotoxic effect against hepatocellular carcinoma cells (HepG 2) with IC value of 1.3 μM.

Natural Products Repertoire of the Red Sea

“…Compounds 85 and 86 showed cytotoxic activities against MCF-7 cells, with IC 50 values of 2.4 and 3.8 μM, respectively. Compound 86 displayed also cytotoxicity against HepG 2 cells with IC 50 value of 1.3 μM [ 97 ]. Bioactivity-guided fractionation of the marine sponge Callyspongia aff.…”

Cytotoxic Sesterterpenes from Thai Marine Sponge Hyrtios erectus

“…Marine organisms have always been an attractive source of natural products with novel and exotic structures and useful biological activities [1,2,3,4,5,6,7,8,9,10,11]. Marine sponges of the genus Hyrtios (order Dictyoceratida family Thorectidae) have yielded scalarane [6,8,12,13,14] and manoalide [12] types sesterterpenes, which are important groups of active secondary metabolites.…”

Marine natural products from sponges (Porifera) of the order Dictyoceratida (2013 to 2019); a promising source for drug discovery

“…Structures of compounds(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).This journal is © The Royal Society of Chemistry 2020 RSC Adv., 2020, 10, 34959-34976 | 34961 Review RSC Advances Open Access Article. Published on 21 September 2020.…”