Cytotoxic activity of coumarins from<i>Micromelum minutum</i>

Susidarti, Ratna Asmah; Rahmani, Mawardi; Ismail, Hazar Bebe Mohd; Sukari, Mohamad Aspollah; Hin, Taufiq-Yap Yun; Lian, Gwendoline Ee Cheng; Ali, Abdul Manaf

doi:10.1080/13880200802436513

Cited by 21 publications

(18 citation statements)

References 10 publications

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“…Koriem et al (2013) demonstrated the antihyperglycemic, antihyperlipidemic and antiapoptotic activities of Micromelum minutum, which are all related to Microminutinin coumarin ingredient of the plant seeds. Identified chemical constituents for M. minutum also have potential biological property containing coumarins as potent cytotoxic agents against the T-lymphoblastic leukemia cell line (Susidarti et al 2009). This finding supports the ethnomedicinal claims among Agusan Manobo for M. minutum as a treatment for cancer.…”

Section: Several Bioactive Compounds and Essential Oils Of Othersupporting

confidence: 75%

Ethnomedicinal appraisal and conservation status of medicinal plants among the Manobo tribe of Bayugan City, Philippines

et al. 2020

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Abstract. Dapar MLG, Meve U, Liede-Schumann S, Alejandro GJD. 2020. Ethnomedicinal appraisal and conservation status of medicinal plants among the Manobo tribe of Bayugan City, Philippines. Biodiversitas 21: 3843-3855. Manobo tribe is one of the most populated indigenous communities in the Philippines clustered in various parts of Mindanao archipelago with distinct cultural traditions and medicinal practices. This study aims to document the Agusan Manobo tribe medicinal plant uses and knowledge and to assess the conservation status of their medicinal plants found in upland ancestral lands where ethnomedicinal practices still prevail. Ethnomedicinal data were gathered from 95 key informants through semi-structured interviews, focus group discussions, and guided field walks in five selected upland barangays of Bayugan City. Family importance value (FIV) and relative frequency of citation (RFC) were quantified. The conservation status of their medicinal plants was assessed based on the international and national listing of threatened species. A total of 90 species belonging to 82 genera and 41 families were identified as ethnomedicinally important. Highest FIV (98.9) was reported for Piperaceae in treatment for skin diseases and infections. The most cited medicinal plant species was Piper decumanum L. (RFC=0.95), which is primarily used in treatment for insect and snake bites. Conservation assessment revealed that the five upland areas of the Agusan Manobo tribe are habitats of endemic, endangered, vulnerable and threatened species. The results of this study present the rich ethnomedicinal knowledge of Agusan Manobo cultural community, which could serve as a useful source of information to improve community healthcare and environmental conservation and management. Local people and the government should actively participate in shared management responsibilities for viable conservation strategies and sustainable use of the cultural community resources.

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Section: Several Bioactive Compounds and Essential Oils Of Othersupporting

confidence: 75%

Ethnomedicinal appraisal and conservation status of medicinal plants among the Manobo tribe of Bayugan City, Philippines

et al. 2020

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“…In this communication we would like report the structural determination of two new xanthones, identified as nodusuxanthone ( 1a ) and trapezifolixanthone A ( 2 ), together with four other terpenoids obtained from the crude extracts of Calophyllum nodusum . This is in continuation of our work on bioactive constituents of Malaysian tropical plants [ 11 , 12 , 13 , 14 ].…”

Section: Introductionsupporting

confidence: 68%

Two New Xanthones from Calophyllum nodusum (Guttiferae)

et al. 2011

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The air-dried powdered stem bark of Calophyllum nodusum (Guttiferea) collected from Sandakan (Sabah, Malaysia), was extracted sequentially with hexane, chloroform and methanol. The solvents were removed by rotary evaporator to give dark viscous extracts. Detailed and repeated chromatographic separation of the extracts lead to isolation of two new xanthones, identified as nodusuxanthone (1a) and trapezifolixanthone A (2). Other common terpenoids such as betulinic acid, lupeol, stigmasterol and friedelin were also isolated from the extracts and identified. The structures of the compounds were established by detailed spectral analysis and comparison with previously reported data.

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“…Previous works on the phenolic constituents of this genus indicated the occurrence of new and unusual flavone derivatives bearing isoprenoid side chains and related phenolic compounds [5][6][7]. In continuation of our work on bioactive compounds from tropical plants [8,9], we wish to report the isolation and structural determination of six prenylated flavones from stem bark of Artocarpus altilis.…”

Section: Introductionmentioning

confidence: 97%

Prenylated flavones from Artocarpus altilis

et al. 2010

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Six prenylated flavones, including one new compound, were isolated and identified from the stem bark extracts of Artocarpus altilis. The new prenylated flavone hydroxyartocarpin (1) was characterized as 3-(gamma,gamma-dimethylallyl)-6-isopentenyl-5,8,2',4'-tetrahydroxy-7-methoxyflavone and the known compounds were artocarpin (2), morusin (3), cycloartobiloxanthone (4), cycloartocarpin A (5) and artoindonesianin V (6). The structures of the compounds were determined by spectroscopic methods (IR, MS, (1)H-NMR and (13)C-NMR) and comparison with published data for the known compounds.

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Cytotoxic activity of coumarins fromMicromelum minutum

Cited by 21 publications

References 10 publications

Ethnomedicinal appraisal and conservation status of medicinal plants among the Manobo tribe of Bayugan City, Philippines

Ethnomedicinal appraisal and conservation status of medicinal plants among the Manobo tribe of Bayugan City, Philippines

Two New Xanthones from Calophyllum nodusum (Guttiferae)

Prenylated flavones from Artocarpus altilis

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