Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells

Taş, Ayça; Çakmak, Neşe Keklikçioğlu; Agbektaş, Tuğba; Siliğ, Yavuz

doi:10.32571/ijct.613536

Cited by 11 publications

(6 citation statements)

References 22 publications

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“…MNP effects on the cellular microenvironment and tissue physiology have not been well studied. It is necessary to develop effective therapies and obtain an in-depth understanding of anticancer activity of mechanical stimuli [86][87][88][89][90]. Additionally, the increased cytotoxic effect of TiO 2 -ZnO-Au nanocomposites was compared to that of TiO 2 NPs and ZnONPs against Du-145 prostate cancer cells [91].…”

Section: Discussionmentioning

confidence: 99%

Interactive Effects of Biosynthesized Nanocomposites and Their Antimicrobial and Cytotoxic Potentials

et al. 2021

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The present study investigated the biosynthesis of silver (AgNPs), zinc oxide (ZnONPs) and titanium dioxide (TiO2NPs) nanoparticles using Aspergillusoryzae, Aspergillusterreus and Fusariumoxysporum. Nanocomposites (NCs) were successfully synthesized by mixing nanoparticles using a Sonic Vibra-Cell VC/VCX processor. A number of analytical techniques were used to characterize the synthesized biological metal nanoparticles. Several experiments tested biologically synthesized metal nanoparticles and nanocomposites against two types of human pathogenic bacteria, including Gram-positive Staphylococcus aureusand methicillin-resistant Staphylococcus aureus (MRSA), and Gram-negative Escherichia coli and Pseudomonasaeruginosa. Additionally, the antitumor activity in HCT-116 cells (colonic carcinoma) was also evaluated. Significant antimicrobial effects of various synthesized forms of nanoparticles and nanocomposites against E. coli and P. aeruginosa bacteria were detected. Various synthesized biogenic forms of nanoparticles and nanocomposite (9.0 to 29 mm in diameter) had high antibacterial activity and high antitumor activity against HCT-116 cells (colonic carcinoma) with IC50 values of 0.7–100 µg/mL. Biosynthesized NPs are considered an alternative to large-scale biosynthesized metallic nanoparticles and nanocomposites, are simple and cost effective, and provide stable nanomaterials.

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Section: Discussionmentioning

confidence: 99%

Interactive Effects of Biosynthesized Nanocomposites and Their Antimicrobial and Cytotoxic Potentials

et al. 2021

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“…However, after a few years, tumor recurrence can shorten chemotherapy as a valuable therapeutic option for prostate cancer. However, associated side effects such as toxicity, fatigue, difficulty breathing, low white blood cell count, and blood clotting hamper their efficacy for tumor eradication [173]. Recently, targeted drug delivery and stimulus-responsive release have minimized toxicity and improved drug delivery and accumulation at the target site [174,175].…”

Section: Prostate Cancermentioning

confidence: 99%

“…Different inorganic nanoparticles such as TiO 2 , graphene oxide, iron oxide, and porous silica have been used for drug delivery and anticancer therapeutic agents [173]. TiO 2 NPs are considered potent drug carriers and photosensitizers due to their low cost, toxicity, and non-photobleaching characteristics [176,177].…”

Section: Prostate Cancermentioning

confidence: 99%

Updates on Titanium Dioxide

2023

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IVthat influence the crystalline structure, morphology, and adhesion of TiO 2 films to ginger lily fibers. The surface properties of TiO 2 films are determined using analytical techniques such as X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS), and their morphology and elemental composition are determined by scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDS). Chapter 9 discusses the complex impact of gamma rays on materials of TiO 2 and their practical use in photovoltaic contexts. Chapter 10 discusses plasmonic-TiO 2 nanohybrids for environmental and energy applications. Chapter 11 reviews the design, fabrication, and theranostic biomedical applications of nano titania.I hope this book is widely read. If we are to avoid the blunders of the past, then we need to change direction and start benefiting from the knowledge base created by the scientists. We did not have this chance a decade ago. Now is the right time.

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“…Extensive research has been documented in the literature, exploring the effects of diverse nanoparticles (NPs) on enzyme activity in microorganisms, animals, and plants [28][29][30][31][32][33]. In particular, biochemical, physiological and molecular effects have been investigated in different soil organisms and microorganisms.…”

Section: Introductionmentioning

confidence: 99%

The effects of silver nanoparticles (AgNPs) on thermophilic bacteria: Antibacterial, morphological, physiological and biochemical investigations

Jahan,

Matpan Bekler,

Tunç

et al. 2023

Preprint

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Since thermophilic microorganisms are valuable source of thermostable enzymes, it is essential to recognize the potential toxicity of silver nanoparticles used in diverse industrial sectors. Thermophilic bacteria Geobacillus vulcani 2Cx, Bacillus licheniformis 3CA, Paenibacillus macerans 3CA1, Anoxybacillus ayderensis FMB1, and Bacillus paralicheniformis FMB2-1 were selected, and their MIC and MBC values were assessed by treating with AgNPs at a range of 62.5-1500 μg mL−1. The growth inhibition curves showed that G. vulcani 2Cx, and B. paralicheniformis FMB2-1 strains were more sensitive to AgNPs, demonstrating a reduction in population by 71.1% and 31.7% at 62.5 μg mL−1 and by 82.9% and 72.8% at 250 μg mL−1, respectively. TEM and FT-IR analysis revealed that AgNPs caused structural damage, cytoplasmic leakage, and disruption of cellular integrity. Furthermore, the cell viability showed a significant decrease alongside an increase in superoxide radicals (SOR; O2·−) production. The β-galactosidase biosynthesis decreased to 28.8% levels at 500 μg mL−1 AgNPs for G. vulcani 2Cx, 32.2% at 250 μg mL−1 for A. ayderensis FMB1, 38.8% only at 62.5 μg mL−1 but completely inhibited at 500 μg mL−1 for B. licheniformis 3CA. Moreover, B. paralicheniformis FMB2-1 showed significant decrease to 11.2% at 125 μg mL−1. This study is the first to reveal the toxic effects of AgNPs on thermophilic bacteria.

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Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells

Cited by 11 publications

References 22 publications

Interactive Effects of Biosynthesized Nanocomposites and Their Antimicrobial and Cytotoxic Potentials

Interactive Effects of Biosynthesized Nanocomposites and Their Antimicrobial and Cytotoxic Potentials

Updates on Titanium Dioxide

The effects of silver nanoparticles (AgNPs) on thermophilic bacteria: Antibacterial, morphological, physiological and biochemical investigations

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