Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus

Qin, Xu‐Jie; Shu, Tong; Qian, Yu; Yan, Hong‐Bin; Ni, Wei; An, Lin‐Kun; Li, Pan-Pan; Zhi, Yin-E; Khan, Afsar; Liu, Haiyang

doi:10.1007/s13659-017-0138-6

Cited by 13 publications

(2 citation statements)

References 13 publications

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“…This activity has been reported to be even better than the positive control (VP-16, 20.26 µM). Compounds 174 and 176 also exhibited cytotoxicity against A549 cell lines with IC 50 values of 12.85 and 10.03 µM, respectively, which is also better than VP-16 (IC 50 = 25.79 ± 6.2 µM), respectively [67]. 2), whereas, compounds 183-187 exhibited significant IC 50 values (0.36-6.50 µM) [68].…”

Section: Syncarpic Acid/β-triketones-based Meroterpenesmentioning

confidence: 94%

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

et al. 2021

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Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.

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Section: Syncarpic Acid/β-triketones-based Meroterpenesmentioning

confidence: 94%

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

et al. 2021

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“…However, callisalignenes I showed a cytotoxic effect against human colon cancer cells. Additionally, callisalignenes G and I displayed cytotoxicity against lung cancer cells, which was more potent than the standard drug VP-16 ( Qin et al, 2017a ; 2017b ). Zhang et al isolated fischernolides B and D from Euphorbia fischeriana Steud.…”

Section: Biological Activities Of Meroterpenoidsmentioning

confidence: 97%

Biological activities of meroterpenoids isolated from different sources

et al. 2022

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Meroterpenoids are natural products synthesized by unicellular organisms such as bacteria and multicellular organisms such as fungi, plants, and animals, including those of marine origin. Structurally, these compounds exhibit a wide diversity depending upon the origin and the biosynthetic pathway they emerge from. This diversity in structural features imparts a wide spectrum of biological activity to meroterpenoids. Based on the biosynthetic pathway of origin, these compounds are either polyketide-terpenoids or non-polyketide terpenoids. The recent surge of interest in meroterpenoids has led to a systematic screening of these compounds for many biological actions. Different meroterpenoids have been recorded for a broad range of operations, such as anti-cholinesterase, COX-2 inhibitory, anti-leishmanial, anti-diabetic, anti-oxidative, anti-inflammatory, anti-neoplastic, anti-bacterial, antimalarial, anti-viral, anti-obesity, and insecticidal activity. Meroterpenoids also possess inhibitory activity against the expression of nitric oxide, TNF- α, and other inflammatory mediators. These compounds also show renal protective, cardioprotective, and neuroprotective activities. The present review includes literature from 1999 to date and discusses 590 biologically active meroterpenoids, of which 231 are from fungal sources, 212 are from various species of plants, and 147 are from marine sources such as algae and sponges.

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