Cytotoxic Alkaloids from<i>Hippeastrum solandriflorum</i>Lindl.

Carvalho, Kaline Rodrigues; Silva, Alison B.; Torres, Maria Conceição M.; Pinto, Francisco C. L.; Guimarães, Larissa Alves; Rocha, Danilo D.; Silveira, Edilberto R.; Costa-Lotufo, Letı́cia V.; Braz‐Filho, Raimundo; Pessoa, Otília Deusdênia Loiola

doi:10.5935/0103-5053.20150176

Cited by 9 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several of these novel AAs belong to known structural types, while others harbor new structures. The 91 AAs were classified in this manuscript as I) norbelladine-type (1-6), II) cherylline-type (7, 8), III) galantamine-type (9-16), IV) lycorine-type (17-25), V) homolycorine-type (26)(27)(28)(29)(30), VI) crinine-type (31-50), VII) narciclasine-type (51), VIII) pretazettine-type (52-54), IX) montanine-type (55), and X) other types including AAs related to plicamine (56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67), seco-plicamine (68-70), cripowellin (71)(72)(73)(74)(75)(76), mesembrine (77,78), and various others AAs (79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91). Structures of novel AAs belonging to the I to III scaffold types (norbelladine-, cherylline-, and galantamine-type) are depicted in Figure 3, whereas types IV and V (lycorine-and homolycorine-type) are represented in Figure 4.…”

Section: Occurrence Of Amaryllidaceae Alkaloidsmentioning

confidence: 99%

“…Furthermore, it has been demonstrated that the presence of the unaltered diol functionality in the C-ring in its original configuration in lycorine series, the stereochemistry of the C/D ring junction and the conformational freedom of the C-ring were required for the anticancer activity [96] [88]. Cripowellin-form (71)(72)(73)(74)(75)(76) and Zephycandidine A (81) belonging to the other-type of AA may be potential targets for further anticancer investigations.…”

Section: Antitumoral Cytotoxic Activitymentioning

confidence: 99%

“…They were also evaluated for their antioxidant potential activities using ABTS •+ (2,2 -azino-bis(3-ethylbenzo-thiazoline-6-sulphonic acid) and DPPH (1,1-diphenyl-2-picrylhydrazyl) methods. AAs (72), (73), and (74) showed significant antiradical activity with IC 50 values of from 52.2 to 80.1µM.…”

Section: Anti-inflammatory and Antioxidant Activitymentioning

confidence: 99%

See 2 more Smart Citations

Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

Koirala

Mérindol

et al. 2020

Molecules

View full text Add to dashboard Cite

Alkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidaceae alkaloids (AAs) family. AAs are specifically remarkable for their diverse pharmaceutical properties, as exemplified by the success of galantamine used to treat the symptoms of Alzheimer’s disease. This review addresses the isolation, biological, and structure activity of AAs discovered from January 2015 to August 2020, supporting their therapeutic interest.

show abstract

Section: Occurrence Of Amaryllidaceae Alkaloidsmentioning

confidence: 99%

Section: Antitumoral Cytotoxic Activitymentioning

confidence: 99%

See 1 more Smart Citation

Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

Koirala

Mérindol

et al. 2020

Molecules

View full text Add to dashboard Cite

show abstract

“…This genus has been traditionally used to cure piles, tumors and various inflammatory disorders such as asthma [ 19 ]. Physiological activities reported for plants of this genus include psychopharmacological [ 20 ], against Trichomonas vaginalis [ 21 ] and cytotoxicity [ 22 , 23 ]. The species H. reticulatum is widely used as an ornamental plant due to its colorful flowers ranging from light pink to dark purple [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Hippeastrum reticulatum (Amaryllidaceae): Alkaloid Profiling, Biological Activities and Molecular Docking

et al. 2017

View full text Add to dashboard Cite

The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. The aim of this work was to perform the first detailed study of the alkaloid constituents of Hippeastrum reticulatum (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhibitory activities of the epimers (6α-hydroxymaritidine and 6β-hydroxymaritidine). Twelve alkaloids were identified in H. reticulatum: eight known alkaloids by GC-MS and four unknown (6α-hydroxymaritidine, 6β-hydroxymaritidine, reticulinine and isoreticulinine) by NMR. The epimer mixture (6α-hydroxymaritidine and 6β-hydroxymaritidine) showed low activity against all protozoan parasites tested and weak AChE-inhibitory activity. Finally, a molecular docking analysis of AChE and BuChE proteins showed that isoreticulinine may be classified as a potential inhibitory molecule since it can be stabilized in the active site through hydrogen bonds, π-π stacking and hydrophobic interactions.

show abstract

“…A majority of the world's population, especially in developing countries, is treated only with traditional herbal remedies (ANSM, 2016). From aspirin to taxol, the modern pharmaceutical industry itself still relies heavily on the diversity of plant secondary metabolites to find new molecules with novel biological properties (Canvalho et al, 2015). Each plant can contain several thousand different compounds (Adjanohoun and Aké-Assi, 2008) whose various uses are aimed at overcoming suffering and improving the health of men (Canvalho et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Automatic Identification of Molecules in a Thin-Film Extract Combined with Laser

Bi¹,

Ouattara²,

Clément³

2018

American Journal of Engineering and Applied Sciences

View full text Add to dashboard Cite

This paper presents the automation of the thin-layer chromatography technique whose separation and identification of molecules present in a mixture are currently done manually and laboriously. We have therefore found an interest in automating this technique. In this part, the method implemented comprises 2 steps. First we proceeded to the segmentation of the spots obtained on the chromatographic plate. We then developed a program to identify families of molecules such as coumarins, terpenes, tannins, flavonoids, polyphenols, etc. by calculating segmentation parameters such as standard deviation, entropy, mean pixel intensity and frontal ratio from an algorithm on the matlab software. Finally our results have been compared to the results obtained by the traditional identification technique in laboratories. Some similarity between the two results obtained shows the reliability and the robustness of our technique.

show abstract

Cytotoxic Alkaloids fromHippeastrum solandriflorumLindl.

Cited by 9 publications

References 0 publications

Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

Hippeastrum reticulatum (Amaryllidaceae): Alkaloid Profiling, Biological Activities and Molecular Docking

Automatic Identification of Molecules in a Thin-Film Extract Combined with Laser

Contact Info

Product

Resources

About