Cytotoxic and apoptotic effects of Poly(maleic anhydride-co-vinyl acetate) drug carrier copolymer on MCF-7 and MDA-MB-231 breast cancer cells

Abstract

In recent years, copolymers are frequently used in many areas. The biocompatibility of any copolymer should be examined for practical application. One of these copolymers is Poly [(maleic anhydride)-co-(vinyl acetate)] (MAVA), and the usage area of MAVA is quite limited. In this study, the cytotoxic effect of MAVA on MDA-MB-231 and MCF-7 human breast cancer cells was determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), and apoptotic cells are marked with DAPI staining. For this purpose, MDA-MB-231 and MCF-7 human breast cancer cells were incubated with different concentrations of MAVA